Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Darren C. Tomlinson"'
Autor:
Sophie E. Roberts, Heather L. Martin, Danah Al-Qallaf, Anna A. Tang, Christian Tiede, Thembaninkosi G. Gaule, Albor Dobon-Alonso, Ross Overman, Sachin Shah, Hadrien Peyret, Keith Saunders, Robin Bon, Iain W. Manfield, Sandra M. Bell, George P. Lomonossoff, Valerie Speirs, Darren C. Tomlinson
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110461- (2024)
Summary: Monoclonal antibodies have revolutionized therapies, but non-immunoglobulin scaffolds are becoming compelling alternatives owing to their adaptability. Their ability to be labeled with imaging or cytotoxic compounds and to create multimeric
Externí odkaz:
https://doaj.org/article/afbbfa1f915d4d408b05c261d3880b47
Publikováno v:
Biomolecules, Vol 14, Iss 8, p 1040 (2024)
Src homology 3 (SH3) domains play a critical role in mediating protein–protein interactions (PPIs) involved in cell proliferation, migration, and the cytoskeleton. Despite their abundance in the human proteome, the functions and molecular interacti
Externí odkaz:
https://doaj.org/article/09656d7271eb4a709813154e06a09ec5
Autor:
Heather L. Martin, Amy L. Turner, Julie Higgins, Anna A. Tang, Christian Tiede, Thomas Taylor, Sitthinon Siripanthong, Thomas L. Adams, Iain W. Manfield, Sandra M. Bell, Ewan E. Morrison, Jacquelyn Bond, Chi H. Trinh, Carolyn D. Hurst, Margaret A. Knowles, Richard W. Bayliss, Darren C. Tomlinson
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113184- (2023)
Summary: Kinases are important therapeutic targets, and their inhibitors are classified according to their mechanism of action, which range from blocking ATP binding to covalent inhibition. Here, a mechanism of inhibition is highlighted by capturing
Externí odkaz:
https://doaj.org/article/602d6e2e2cea4be1917c7c7c7b34ebd6
Autor:
Jack A. Caudwell, Jordan M. Tinkler, Ben R.G. Johnson, Kenneth J. McDowall, Fayez Alsulaimani, Christian Tiede, Darren C. Tomlinson, Steven Freear, W. Bruce Turnbull, Stephen D. Evans, Jonathan A.T. Sandoe
Publikováno v:
Biofilm, Vol 4, Iss , Pp 100074- (2022)
Staphylococcus aureus (S. aureus) is an important human pathogen and a common cause of bloodstream infection. The ability of S. aureus to form biofilms, particularly on medical devices, makes treatment difficult, as does its tendency to spread within
Externí odkaz:
https://doaj.org/article/d1f78f448c774844abf1c65ef9338d66
Autor:
Katarzyna Z. Haza, Heather L. Martin, Ajinkya Rao, Amy L. Turner, Sophie E. Saunders, Britta Petersen, Christian Tiede, Kevin Tipping, Anna A. Tang, Modupe Ajayi, Thomas Taylor, Maia Harvey, Keri M. Fishwick, Thomas L. Adams, Thembaninkosi G. Gaule, Chi H. Trinh, Matthew Johnson, Alexander L. Breeze, Thomas A. Edwards, Michael J. McPherson, Darren C. Tomlinson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Oncogenic RAS mutants remain difficult to target with small molecules. Here, the authors show that RAS-binding Affimer proteins inhibit RAS signaling while binding diverse regions on the RAS surface, suggesting the potential to use Affimers as tools
Externí odkaz:
https://doaj.org/article/9fb0e318fb534431a1e30f0ac4d27ca1
Autor:
Shazana Hilda Shamsuddin, David G. Jayne, Darren C. Tomlinson, Michael J. McPherson, Paul A. Millner
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Carcinoembryonic antigen (CEA) is the only blood based protein biomarker at present, used for preoperative screening of advanced colorectal cancer (CRC) patients to determine the appropriate curative treatments and post-surveillance screenin
Externí odkaz:
https://doaj.org/article/1a33adcba2a44a18b93a84d48aebf2a6
Autor:
Rhodri J. King, Katharina Schuett, Christian Tiede, Vera Jankowski, Vicky John, Abhi Trehan, Katie Simmons, Sreenivasan Ponnambalam, Robert F. Storey, Colin W.G. Fishwick, Michael J. McPherson, Darren C. Tomlinson, Ramzi A. Ajjan
Publikováno v:
Haematologica, Vol 106, Iss 6 (2020)
Complement C3 binds fibrinogen and compromises fibrin clot lysis thereby enhancing thrombosis risk. We investigated the role of fibrinogen-C3 interaction as a novel therapeutic target to reduce thrombosis risk by analysing: i) consistency in the fibr
Externí odkaz:
https://doaj.org/article/0a7a6073a1f94ae8b8c4a4c9e4c51308
Autor:
Gina A. Smith, Gareth W. Fearnley, Izma Abdul-Zani, Stephen B. Wheatcroft, Darren C. Tomlinson, Michael A. Harrison, Sreenivasan Ponnambalam
Publikováno v:
Biology Open, Vol 6, Iss 10, Pp 1404-1415 (2017)
Cell surface receptors can undergo recycling or proteolysis but the cellular decision-making events that sort between these pathways remain poorly defined. Vascular endothelial growth factor A (VEGF-A) and vascular endothelial growth factor receptor
Externí odkaz:
https://doaj.org/article/0083afd86eff426b9d979f5c7df686ce
Autor:
Gareth W. Fearnley, Gina A. Smith, Izma Abdul-Zani, Nadira Yuldasheva, Nadeem A. Mughal, Shervanthi Homer-Vanniasinkam, Mark T. Kearney, Ian C. Zachary, Darren C. Tomlinson, Michael A. Harrison, Stephen B. Wheatcroft, Sreenivasan Ponnambalam
Publikováno v:
Biology Open, Vol 5, Iss 5, Pp 571-583 (2016)
Vascular endothelial growth factor A (VEGF-A) binding to the receptor tyrosine kinase VEGFR2 triggers multiple signal transduction pathways, which regulate endothelial cell responses that control vascular development. Multiple isoforms of VEGF-A can
Externí odkaz:
https://doaj.org/article/3e3d9e669a4f443da487cf76e60f7baf
Autor:
Oleg A. Karpov, Gareth W. Fearnley, Gina A. Smith, Jayakanth Kankanala, Michael J. McPherson, Darren C. Tomlinson, Michael A. Harrison, Sreenivasan Ponnambalam
Publikováno v:
AIMS Biophysics, Vol 2, Iss 4, Pp 476-502 (2015)
Receptor tyrosine kinases (RTKs) are membrane proteins that control the flow of information through signal transduction pathways, impacting on different aspects of cell function. RTKs are characterized by a ligand-binding ectodomain, a single transme
Externí odkaz:
https://doaj.org/article/58bd594031e341e1855696de9aa98863