Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Darren C. Robertson"'
Autor:
João Antonio de Queiroz Oliveira, Darren C. Robertson, Sara Brett, Gerben Bouma, Leigh M. Felton, Kirsty J. Hicks, Virginia Norris, Disala Fernando, Ruth M. Tarzi, Michael Herdman, Stefano Zamuner, Andrew Want, Arpita Choudhury
Publikováno v:
British Journal of Clinical Pharmacology. 83:1976-1990
Aims GSK3050002, a humanized IgG1κ antibody with high binding affinity to human CCL20, was administered in a first-in-human study to evaluate safety, pharmacokinetics (PK) and pharmacodynamics (PD). An experimental skin suction blister model was emp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::604f98ebd1055b20d68cade10a1c8c75
https://doi.org/10.1111/bcp.13286
https://doi.org/10.1111/bcp.13286
Autor:
Finny Paterson, Iain Uings, John P. Iredale, Lisa Derr, George E. Dukes, Dawn Lyster, Andreas Tsoumanis, Lesley Briody, Natalie Z.M. Homer, Darren C. Robertson, Xiaozhong Zheng, Damian J. Mole, Alastair J. Hayes, Christos Skouras, Wayne L. Wright, O. James Garden, Toby B J Murray, Rowan W. Parks, Scott P. Webster, Heather Spence, John Liddle, Margaret Binnie
Publikováno v:
Scientific Reports
Skouras, C, Zheng, X, Binnie, M, Homer, N Z M, Murray, T B J, Robertson, D, Briody, L, Paterson, F, Spence, H, Derr, L, Hayes, A J, Tsoumanis, A, Lyster, D, Parks, R W, Garden, O J, Iredale, J P, Uings, I J, Liddle, J, Wright, W L, Dukes, G, Webster, S P & Mole, D J 2016, ' Increased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis ', Scientific Reports, vol. 6, pp. 33951 . https://doi.org/10.1038/srep33951
Skouras, C, Zheng, X, Binnie, M, Homer, N Z M, Murray, T B J, Robertson, D, Briody, L, Paterson, F, Spence, H, Derr, L, Hayes, A J, Tsoumanis, A, Lyster, D, Parks, R W, Garden, O J, Iredale, J P, Uings, I J, Liddle, J, Wright, W L, Dukes, G, Webster, S P & Mole, D J 2016, ' Increased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis ', Scientific Reports, vol. 6, pp. 33951 . https://doi.org/10.1038/srep33951
Inhibition of kynurenine 3-monooxygenase (KMO) protects against multiple organ dysfunction (MODS) in experimental acute pancreatitis (AP). We aimed to precisely define the kynurenine pathway activation in relation to AP and AP-MODS in humans, by carr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdfd3bce56fe1f72812882e67ba2a0f3
https://pubmed.ncbi.nlm.nih.gov/27669975
https://pubmed.ncbi.nlm.nih.gov/27669975
Autor:
Darren C. Robertson, Claire Beaumont, Duncan Richards, Simon M. McHugh, William J. Guiney, Steve R. Thomas, Annelize Koch
Publikováno v:
British Journal of Clinical Pharmacology. 72:133-142
WHAT IS ALREADY KNOWN ABOUT THE SUBJECT • Biliary secretion is often a major route of elimination of drugs and metabolites. Knowledge of the biliary disposition of a drug in man is important in understanding the contribution of this route to overal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01b34c4c15654bfefed96b3dad8346ba
https://doi.org/10.1111/j.1365-2125.2011.03956.x
https://doi.org/10.1111/j.1365-2125.2011.03956.x
Autor:
Elspeth Milne, Darren C. Robertson, Darren J. Shaw, Eva C. Sirinathsinghji, Anisha Patel, Emma Jones, Heather Anderson, Rachel A. Eager, Joe Mayhew, Ada Delaney, Andrew Allchorne, Ignacio Viñuela-Fernández, Natalie Waran, Susan M. Fleetwood-Walker, Neil Macintyre
Publikováno v:
Jones, E, Vinuela-Fernandez, N, Eager, R A, Delaney, A, Anderson, H, Patel, A, Robertson, D C, Allchorne, A, Sirinathsinghji, E C, Milne, E M, Macintyre, N, Shaw, D J, Waran, N K, Mayhew, J & Fleetwood-Walker, S M 2007, ' Neuropathic changes in equine laminitis pain ', Pain, vol. 132, no. 3, pp. 321-31 . https://doi.org/10.1016/j.pain.2007.08.035
Laminitis is a common debilitating disease in horses that involves painful disruption of the lamellar dermo-epidermal junction within the hoof. This condition is often refractory to conventional anti-inflammatory analgesia and results in unremitting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423288f32889d67d614a58afffdbde8f
https://doi.org/10.1016/j.pain.2007.08.035
https://doi.org/10.1016/j.pain.2007.08.035
Autor:
George E. Dukes, Darren C. Robertson, Matthew E. Barton, Odile Dewit, M. O'Donnell, Anne Farmer, Kimberley Hacquoil, R. Hobson
Publikováno v:
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 27(11)
Background A proportion of patients with foregut dysmotility fail to respond to standard interventions. Motilin agonists may be beneficial in this group. We aimed to determine the effect of camicinal, a novel motilin agonist, on gastrointestinal phys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f45e3633b934fb4e1e14c04201ac2a22
https://pubmed.ncbi.nlm.nih.gov/26348542
https://pubmed.ncbi.nlm.nih.gov/26348542
Autor:
William J, Guiney, Claire, Beaumont, Steve R, Thomas, Darren C, Robertson, Simon M, McHugh, Annelize, Koch, Duncan, Richards
Publikováno v:
British journal of clinical pharmacology. 72(1)
To evaluate the non-invasive collection of bile from healthy human subjects for the qualitative characterization of the biliary disposition of a drug, using spectrometric techniques.Twenty subjects underwent non-invasive bile capture using a peroral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aeca5dffff71dddc31c06381d32eaaff
https://pubmed.ncbi.nlm.nih.gov/21366667
https://pubmed.ncbi.nlm.nih.gov/21366667
Autor:
Immaculate Nakalembe, Tracey Dickinson, Andrew Moss, Rory Mitchell, Susan M. Fleetwood-Walker, Roberta Rosie, Gordon Blackburn-Munro, Emer M. Garry, Darren C. Robertson, Ada Delaney, Patrick Robberecht
Publikováno v:
Molecular and cellular neurosciences. 30(4)
Activation of intracellular signaling pathways involving p38 and p42/44 MAP kinases may contribute importantly to synaptic plasticity underlying spinal neuronal sensitization. Inhibitors of p38 or p42/44 pathways moderately attenuated responses of do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa0953358cded197c46022af2f9dacea
https://pubmed.ncbi.nlm.nih.gov/16202621
https://pubmed.ncbi.nlm.nih.gov/16202621
Autor:
Oliver Schmidt, Darren C. Robertson, Paul A. Jones, Natalia Ninkina, John Sharkey, Vladimir L. Buchman
Publikováno v:
Journal of neurochemistry. 89(5)
The growing body of evidence suggests that intermediate products of alpha-synuclein aggregation cause death of sensitive populations of neurones, particularly dopaminergic neurones, which is a critical event in the development of Parkinson's disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b155862d66433604887d75f85c488e
https://pubmed.ncbi.nlm.nih.gov/15147505
https://pubmed.ncbi.nlm.nih.gov/15147505
Autor:
Felipe A. Court, Alun M. Davies, Liz Delaney, Arnon Rosenthal, Katerina K. Papachroni, Natalia Ninkina, Oliver Schmidt, Darren C. Robertson, Susan M. Fleetwood-Walker, Vladimir L. Buchman, Francis O'Neill
Publikováno v:
Ninkina, N, Papachroni, K, Robertson, D C, Schmidt, O, Delaney, L, O'Neill, F, Court, F, Rosenthal, A, Fleetwood-Walker, S M, Davies, A M & Buchman, V L 2003, ' Neurons expressing the highest levels of gamma-synuclein are unaffected by targeted inactivation of the gene ', Molecular and Cellular Biology, vol. 23, no. 22, pp. 8233-45 . https://doi.org/10.1128/MCB.23.22.8233-8245.2003
Homologous recombination in ES cells was employed to generate mice with targeted deletion of the first three exons of the gamma-synuclein gene. Complete inactivation of gene expression in null mutant mice was confirmed on the mRNA and protein levels.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f54071ee4cea6800ab1358fbcccfb70
https://www.pure.ed.ac.uk/ws/files/14461319/Neurons_Expressing_the_Highest_Levels_of_Synuclein_Are_Unaffected_by_Targeted_Inactivation_of_the_Gene.pdf
https://www.pure.ed.ac.uk/ws/files/14461319/Neurons_Expressing_the_Highest_Levels_of_Synuclein_Are_Unaffected_by_Targeted_Inactivation_of_the_Gene.pdf
Autor:
D.A. McCulloch, Darren C. Robertson, Melanie S. Johnson, Craig Mackenzie, Philip R. Holland, E. Ronaldson, Rory Mitchell, E. M. Lutz
Publikováno v:
Biochemical Society transactions. 30(4)
The receptors for the neuropeptides vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide are strong activators of adenylate cyclase, but recent evidence suggests that they can elicit a number of additional intracel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e29c2c79414b21e341cbbbfc41d26c1
https://pubmed.ncbi.nlm.nih.gov/12196111
https://pubmed.ncbi.nlm.nih.gov/12196111