Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Darren C, Holland"'
Autor:
Darren C. Holland, Dale W. Prebble, Mark J. Calcott, Wayne A. Schroder, Francesca Ferretti, Aaron Lock, Vicky M. Avery, Milton J. Kiefel, Anthony R. Carroll
Publikováno v:
Molecules, Vol 29, Iss 15, p 3648 (2024)
Marine natural products (MNPs) continue to be tested primarily in cellular toxicity assays, both mammalian and microbial, despite most being inactive at concentrations relevant to drug discovery. These MNPs become missed opportunities and represent a
Externí odkaz:
https://doaj.org/article/f89cc53b0fe941b8a953a64e5fcc6f23
Publikováno v:
Molecules, Vol 29, Iss 12, p 2806 (2024)
Synthetic efforts toward complex natural product (NP) scaffolds are useful ones, particularly those aimed at expanding their bioactive chemical space. Here, we utilised an orthogonal cheminformatics-based approach to predict the potential biological
Externí odkaz:
https://doaj.org/article/65b79bc8fa294b2daf437a7e93dec686
Autor:
Darren C. Holland, Anthony R. Carroll
Publikováno v:
Molecules, Vol 29, Iss 3, p 594 (2024)
NMR fingerprints are valuable tools for analyzing complex natural product mixtures and identifying incorrectly assigned structures in the literature. Our diagnostic NMR fingerprints for formyl phloroglucinol meroterpenoids revealed discrepancies in t
Externí odkaz:
https://doaj.org/article/2af981a502794a91a449e1bd1178c8d4
Autor:
James R. Baxter, Darren C. Holland, Brody Gavranich, Dean Nicolle, Joshua B. Hayton, Vicky M. Avery, Anthony R. Carroll
Publikováno v:
Journal of Natural Products. 86:1317-1334
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7a757d00ec0299f305026a1c603e9e8
https://doi.org/10.1021/acs.jnatprod.3c00139
https://doi.org/10.1021/acs.jnatprod.3c00139
Autor:
Dale W. Prebble, Darren C. Holland, Joshua B. Hayton, Francesca Ferretti, Laurence K. Jennings, Jack Everson, Mingming Xu, Milton J. Kiefel, George D. Mellick, Anthony R. Carroll
Publikováno v:
Journal of Natural Products. 86:533-540
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63413f741f8e61bdcc1db026e26c23aa
https://doi.org/10.1021/acs.jnatprod.2c01140
https://doi.org/10.1021/acs.jnatprod.2c01140
Publikováno v:
Journal of Natural Products. 85:2474-2479
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::436ceab6b0684be76d322a2511d94e49
https://doi.org/10.1021/acs.jnatprod.2c00151
https://doi.org/10.1021/acs.jnatprod.2c00151
Autor:
Asadhawut Hiranrat, Darren C. Holland, Wilawan Mahabusarakam, John N. A. Hooper, Vicky M. Avery, Anthony R. Carroll
Publikováno v:
Marine Drugs, Vol 19, Iss 2, p 95 (2021)
Two new fluorescent pteridine alkaloids, tedaniophorbasins A (1) and B (2), together with the known alkaloid N-methyltryptamine, were isolated, through application of mass directed purification, from the sponge Tedaniophorbas ceratosis collected from
Externí odkaz:
https://doaj.org/article/d23f84e7e7034c65ba5e9142581ec15c
Publikováno v:
Chemical Science
Diffusion-ordered NMR spectroscopy (DOSY) can be used to analyze mixtures of compounds since resonances deriving from different compounds are distinguished by their diffusion coefficients (D). Previously, DOSY has mostly been used for organometallic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c774433730a4ff85d593b39c69e2cc43
https://doi.org/10.1039/d1sc02940a
https://doi.org/10.1039/d1sc02940a
Publikováno v:
Organic Letters. 22:9574-9578
Citronamine A (1), an isoquinoline alkaloid containing an unprecedented pentacyclic ring system, was isolated from the Australian marine sponge Citronia astra. Based on the combination of MS and NMR analyses and comparison of experimental and TDDFT c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9276f2bd6d0a87864b61a00cdc6b81ea
https://doi.org/10.1021/acs.orglett.0c03633
https://doi.org/10.1021/acs.orglett.0c03633
Publikováno v:
Journal of Natural Products. 83:3435-3444
An extract from the bryozoan Amathia lamourouxi with antiplasmodial activity was identified through high-throughput screening of an Australian marine invertebrate extract library against Plasmodium falciparum. Chemical investigation of A. lamourouxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28b7a73bd76860827b198af6f075c79c
https://doi.org/10.1021/acs.jnatprod.0c00929
https://doi.org/10.1021/acs.jnatprod.0c00929