Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Darren C, Gay"'
Autor:
Drew T. Wagner, Jia Zeng, Constance B. Bailey, Darren C. Gay, Fang Yuan, Hannah R. Manion, Adrian T. Keatinge-Clay
Publikováno v:
Structure (London, England : 1993). 25(7)
In an effort to uncover the structural motifs and biosynthetic logic of the relatively uncharacterized trans-acyltransferase polyketide synthases, we have begun the dissection of the enigmatic dehydrating bimodules common in these enzymatic assembly
Publikováno v:
ACS Chemical Biology
Many polyketide natural products exhibit invaluable medicinal properties, yet much remains to be understood regarding the machinery responsible for their biosynthesis. The recently discovered trans-acyltransferase polyketide synthases employ processi
Autor:
Darren C. Gay, Glen Gay, Abram J. Axelrod, Matthew Jenner, Christoph Kohlhaas, Annette Kampa, Neil J. Oldham, Jörn Piel, Adrian T. Keatinge-Clay
Publikováno v:
Structure. 22:444-451
SummaryThe recently discovered trans-acyltransferase modular polyketide synthases catalyze the biosynthesis of a wide range of bioactive natural products in bacteria. Here we report the structure of the second ketosynthase from the bacillaene trans-a
Publikováno v:
Nature chemical biology
The enoylreductase (ER) is the final common enzyme from modular polyketide synthases (PKSs) to be structurally characterized. The 3.0 Å resolution structure of the didomain comprised of the ketoreductase (KR) and ER from the second module of the spi
Autor:
Delise, Oyola-Robles, Darren C, Gay, Uldaeliz, Trujillo, John M, Sánchez-Parés, Mei-Ling, Bermúdez, Mónica, Rivera-Díaz, Néstor M, Carballeira, Abel, Baerga-Ortiz
Publikováno v:
Protein science : a publication of the Protein Society. 22(7)
Polyunsaturated fatty acids (PUFAs) are made in some strains of deep-sea bacteria by multidomain proteins that catalyze condensation, ketoreduction, dehydration, and enoyl-reduction. In this work, we have used the Udwary-Merski Algorithm sequence ana