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pro vyhledávání: '"Darren B. McAffee"'
Autor:
Darren B. McAffee, Mark K. O’Dair, Jenny J. Lin, Shalini T. Low-Nam, Kiera B. Wilhelm, Sungi Kim, Shumpei Morita, Jay T. Groves
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The linker for activation of T cells (LAT) protein is involved in the activation of T cells. Here the authors discover micron scale LAT condensation events downstream of singly bound T-cell receptors during T cell activation and characterise how LAT
Externí odkaz:
https://doaj.org/article/82822abc182e454491b09902b4a15ff6
Autor:
Darren B. McAffee, Mark K. O’Dair, Jenny J. Lin, Shalini T. Low-Nam, Kiera B. Wilhelm, Sungi Kim, Shumpei Morita, Jay T. Groves
LAT assembly into a two-dimensional protein condensate is a prominent feature of antigen discrimination by T cells. Here, we use single-molecule imaging techniques to resolve the spatial position and temporal duration of each pMHC:TCR molecular bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200a2f90fa627c610edc935830b51b1b
https://doi.org/10.1101/2021.12.16.472676
https://doi.org/10.1101/2021.12.16.472676
