Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Darren B, Leneghan"'
Autor:
Darren B. Leneghan, Kazutoyo Miura, Iona J. Taylor, Yuanyuan Li, Jing Jin, Karl D. Brune, Martin F. Bachmann, Mark Howarth, Carole A. Long, Sumi Biswas
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Vaccine development efforts have recently focused on enabling strong immune responses to poorly immunogenic antigens, via display on multimerisation scaffolds or virus like particles (VLPs). Typically such studies demonstrate improved antibo
Externí odkaz:
https://doaj.org/article/af545a6db3a5422c9c7b0870d3c2cf54
Autor:
Pauline M. van Diemen, Darren B. Leneghan, Iona J. Brian, Kazutoyo Miura, Carole A. Long, Anita Milicic, Sumi Biswas, Christine S. Rollier, David H. Wyllie
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract A persistent goal of vaccine development is the enhancement of the immunogenicity of antigens while maintaining safety. One strategy involves alteration of the presentation of the antigen by combining antigens with a multimeric scaffold. Mul
Externí odkaz:
https://doaj.org/article/9486e757e39243498c51768ecb873839
Autor:
Arianna Marini, Yu Zhou, Yuanyuan Li, Iona J. Taylor, Darren B. Leneghan, Jing Jin, Marija Zaric, David Mekhaiel, Carole A. Long, Kazutoyo Miura, Sumi Biswas
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Development of effective malaria vaccines requires delivery platforms to enhance the immunogenicity and efficacy of the target antigens. This is particularly challenging for transmission-blocking malaria vaccines (TBVs), and specifically for those ba
Externí odkaz:
https://doaj.org/article/b455bad731d24a199302dd720d7e9e80
Autor:
Hongbing Yang, Anuska Llano, Samandhy Cedeño, Annette von Delft, Angelica Corcuera, Geraldine M. Gillespie, Andrew Knox, Darren B. Leneghan, John Frater, Wolfgang Stöhr, Sarah Fidler, Beatriz Mothe, Johnson Mak, Christian Brander, Nicola Ternette, Lucy Dorrell, Eric Sandström, Janet Darbyshire, Frank Post, Christopher Conlon, Jane Anderson, Mala Maini, Timothy Peto, Peter Sasieni, Veronica Miller, Ian Weller, Abdel Babiker, Sarah Pett, Matthew Pace, Natalia Olejniczak, Helen Brown, Nicola Robinson, Jakub Kopycinski, Tomáš Hanke, Alison Crook, Steven Kaye, Myra McClure, Otto Erlwein, Andrew Lovell, Maryam Khan, Michelle Gabrielle, Rachel Bennett, Aminata Sy, Adam Gregory, Fleur Hudson, Charlotte Russell, Gemma Wood, Hanna Box, Cherry Kingsley, Katie Topping, Andrew Lever, Mark Wills, Axel Fun, Mikaila Bandara, Damian Kelly, Simon Collins, Alex Markham, Mary Rauchenberger, Yinka Sowunmi, Shaadi Shidfar, Dominic Hague, Mark Nelson, Maddalena Cerrone, Nadia Castrillo Martinez, Tristan Barber, Alexandra Schoolmeesters, Christine Weaver, Orla Thunder, Jane Rowlands, Christopher Higgs, Serge Fedele, Margherita Bracchi, Lervina Thomas, Peter Bourke, Nneka Nwokolo, Gaynor Lawrenson, Marzia Fiorino, Hinal Lukha, Sabine Kinloch-de Loes, Margaret Johnson, Alice Nightingale, Nnenna Ngwu, Patrick Byrne, Zoe Cuthbertson, Martin Jones, Tina Fernandez, Amanda Clarke, Martin Fisher, Rebecca Gleig, Vittorio Trevitt, Colin Fitzpatrick, Tanya Adams, Fiounnuala Finnerty, John Thornhill, Heather Lewis, Kristin Kuldanek, Julie Fox, Julianne Lwanga, Hiromi Uzu, Ming Lee, Simon Merle, Patrick O’Rourke, Isabel Jendrulek, Taras Zarko Flynn, Mark Taylor, Juan Manuel Tiraboschi, Tammy Murray
Publikováno v:
Cell Reports
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Persistence of HIV through integration into host DNA in CD4(+) T cells presents a major barrier to virus eradication. Viral integration may be curtailed when CD8(+) T cells are triggered to kill infected CD4(+) T cells through recognition of histocom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6f7b05b028eaac835e405a6ac4e7c84
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2035
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2035
Autor:
Hongbing, Yang, Anuska, Llano, Samandhy, Cedeño, Annette, von Delft, Angelica, Corcuera, Geraldine M, Gillespie, Andrew, Knox, Darren B, Leneghan, John, Frater, Wolfgang, Stöhr, Sarah, Fidler, Beatriz, Mothe, Johnson, Mak, Christian, Brander, Nicola, Ternette, Lucy, Dorrell, Tammy, Murray
Publikováno v:
Cell reports. 35(6)
Persistence of HIV through integration into host DNA in CD4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f60d862c97ff36713e938ed237badeee
https://pubmed.ncbi.nlm.nih.gov/33979627
https://pubmed.ncbi.nlm.nih.gov/33979627
Autor:
Johnson Mak, Geraldine M. Gillespie, Darren B. Leneghan, Lucy Dorrell, Andrew Alexander Knox, Angelica Corcuera, Beatriz Mothe, Nicola Ternette, Samandhy Cedeño, Hongbing Yang, Annette von Delft, Christian Brander, Sarah Fidler, John Frater, Wolfgang Stöhr, Anuska Llano, River Trial Study Goup
Publikováno v:
SSRN Electronic Journal.
Persistence of HIV through integration into host DNA in CD4+ T cells presents a major barrier to virus eradication. Viral integration may be curtailed when CD8+ T cells are triggered to kill infected CD4+ T cells through recognition of HLA class I-bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffac2776f051a00ecb4443d7c6517ece
https://doi.org/10.2139/ssrn.3717161
https://doi.org/10.2139/ssrn.3717161
Autor:
Iona J. Taylor, Carole A. Long, Karl D. Brune, Yuanyuan Li, Darren B. Leneghan, Mark Howarth, Jing Jin, Martin F. Bachmann, Kazutoyo Miura, Sumi Biswas
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Leneghan, Darren B; Miura, Kazutoyo; Taylor, Iona J; Li, Yuanyuan; Jin, Jing; Brune, Karl D; Bachmann, Martin; Howarth, Mark; Long, Carole A; Biswas, Sumi (2017). Nanoassembly routes stimulate conflicting antibody quantity and quality for transmission-blocking malaria vaccines. Scientific Reports, 7(1), p. 3811. Nature Publishing Group 10.1038/s41598-017-03798-3
Scientific Reports
Leneghan, Darren B; Miura, Kazutoyo; Taylor, Iona J; Li, Yuanyuan; Jin, Jing; Brune, Karl D; Bachmann, Martin; Howarth, Mark; Long, Carole A; Biswas, Sumi (2017). Nanoassembly routes stimulate conflicting antibody quantity and quality for transmission-blocking malaria vaccines. Scientific Reports, 7(1), p. 3811. Nature Publishing Group 10.1038/s41598-017-03798-3
Scientific Reports
Vaccine development efforts have recently focused on enabling strong immune responses to poorly immunogenic antigens, via display on multimerisation scaffolds or virus like particles (VLPs). Typically such studies demonstrate improved antibody titer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a66dcf92fff92273c45c3a103eb6ae5
https://doaj.org/article/af545a6db3a5422c9c7b0870d3c2cf54
https://doaj.org/article/af545a6db3a5422c9c7b0870d3c2cf54
Publikováno v:
Parasitology. 144:869-876
SUMMARYFK506 and rapamycin (Rap) are immunosuppressive drugs that act principally on T-lymphocytes. The receptors for both drugs are FK506-binding proteins (FKBPs), but the molecular mechanisms of immunosuppression differ. An FK506–FKBP complex inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e44b262a307aef1096e975b2d64756a7
https://doi.org/10.1017/s0031182017000245
https://doi.org/10.1017/s0031182017000245
Autor:
Yuanyuan, Li, Darren B, Leneghan, Kazutoyo, Miura, Daria, Nikolaeva, Iona J, Brian, Matthew D J, Dicks, Alex J, Fyfe, Sarah E, Zakutansky, Simone, de Cassan, Carole A, Long, Simon J, Draper, Adrian V S, Hill, Fergal, Hill, Sumi, Biswas
Publikováno v:
Scientific Reports
Transmission-blocking vaccines (TBV) target the sexual-stages of the malaria parasite in the mosquito midgut and are widely considered to be an essential tool for malaria elimination. High-titer functional antibodies are required against target antig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d86032f00e757fb21ff2aeb602d75c71
https://pubmed.ncbi.nlm.nih.gov/26743316
https://pubmed.ncbi.nlm.nih.gov/26743316
Autor:
Darren B. Leneghan, Angus Bell
Publikováno v:
Parasitology. 142(11)
SUMMARYImmunophilins comprise two protein families, cyclophilins (CYPs) and FK506-binding proteins (FKBPs), and are the major receptors for the immunosuppressive drugs cyclosporin A (CsA) and FK506 (tacrolimus), respectively. Most eukaryotic species
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a01576fe45b5b9cb162f6214a24cb48
https://pubmed.ncbi.nlm.nih.gov/26156578
https://pubmed.ncbi.nlm.nih.gov/26156578