Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Darren A. Murrey"'
Autor:
Haiyan Fu, Marcela P Cataldi, Tierra A Ware, Kimberly Zaraspe, Aaron S Meadows, Darren A Murrey, Douglas M McCarty
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
The reversibility of neuropathic lysosomal storage diseases, including MPS IIIA, is a major goal in therapeutic development, due to typically late diagnoses and a large population of untreated patients. We used self-complementary adeno-associated vir
Externí odkaz:
https://doaj.org/article/5174d7b009934953a3d088bbd567eefa
Autor:
Sarah Lewis, Ellyn Peterson, Darren A. Murrey, Lindsay N. Alfano, Louis G. Chicoine, Danielle A. Griffin, Zarife Sahenk, Louise R. Rodino-Klapac, Linda Lowes, Sharon L. Cheatham, Mark J. Hogan, Beverly Galliers, Kelly J. Lehman, Kathleen Church, N. Miller, John P. Cheatham, Samiah Al-Zaidy, Jerry R. Mendell
Publikováno v:
Human Gene Therapy. 30:794-801
In a previous limb-girdle muscular dystrophy type 2D (LGMD2D) clinical trial, robust alpha-sarcoglycan gene expression was confirmed following intramuscular gene (SGCA) transfer. This paved the way for first-in-human isolated limb infusion (ILI) gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2f49f1ce8624d28c0c98b30316c948
https://doi.org/10.1089/hum.2019.006
https://doi.org/10.1089/hum.2019.006
Autor:
Katie Campbell, Haiyan Fu, Darren A. Murrey, Bartholomew J. Naughton, Brad Bolon, Christopher M. Walker, Tierra Ware, Douglas M. McCarty, F. Jason Duncan, Krista M. D. La Perle, Kevin M. Flanigan, Kim L. McBride, William G. Bremer, Laurie Goodchild, Aaron S. Meadows
Publikováno v:
Human Gene Therapy Clinical Development. 25:72-84
No treatment is currently available for mucopolysaccharidosis (MPS) IIIB, a neuropathic lysosomal storage disease caused by autosomal recessive defect in α-N-acetylglucosaminidase (NAGLU). In anticipation of a clinical gene therapy treatment for MPS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dddbf51e682c074933dab6d9ceb778e0
https://doi.org/10.1089/humc.2013.208
https://doi.org/10.1089/humc.2013.208
Autor:
Vincent Corvest, Mazakazu Hirasawa, Patrice Hamel, David B. Knaff, Bernard Guiard, Darren A. Murrey
Publikováno v:
Molecular Microbiology. 83:968-980
Summary Cytochrome c assembly requires sulphydryls at the CXXCH haem binding site on the apoprotein and also chemical reduction of the haem co-factor. In yeast mitochondria, the cytochrome haem lyases (CCHL, CC1HL) and Cyc2p catalyse covalent haem at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89285fde994b0697cd9d459cf8f7a92f
https://doi.org/10.1111/j.1365-2958.2012.07981.x
https://doi.org/10.1111/j.1365-2958.2012.07981.x
Autor:
Douglas M. McCarty, Aaron S. Meadows, Tierra A Ware, Darren A. Murrey, Marcela Cataldi, Haiyan Fu, Kimberly Zaraspe
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
The reversibility of neuropathic lysosomal storage diseases, including MPS IIIA, is a major goal in therapeutic development, due to typically late diagnoses and a large population of untreated patients. We used self-complementary adeno-associated vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::466090b527cc5c1d2fe10ab75195ebcd
https://pubmed.ncbi.nlm.nih.gov/27324445
https://pubmed.ncbi.nlm.nih.gov/27324445
Autor:
Aaron S. Meadows, Bartholomew J. Naughton, Darren A. Murrey, Peter White, Douglas W. Scharre, F. Jason Duncan, David E. Newsom, Nicoleta Stoicea, Douglas M. McCarty, Haiyan Fu
Publikováno v:
Journal of Alzheimer's disease : JAD. 43(1)
To date, little is known regarding the etiology and disease mechanisms of Alzheimer's disease (AD). There is a general urgency for novel approaches to advance AD research. In this study, we analyzed blood RNA from female patients with advanced AD and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9ebb8da4aa363af54150c7440493891
https://pubmed.ncbi.nlm.nih.gov/25079797
https://pubmed.ncbi.nlm.nih.gov/25079797
Autor:
Kimberly Zaraspe, Aaron S. Meadows, Darren A. Murrey, Peter White, Douglas M. McCarty, Kelly Reed Clark, Haiyan Fu, David E. Newsom, Bartholomew J. Naughton, F. Jason Duncan
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 23(4)
Mucopolysaccharidosis (MPS) IIIA is a neuropathic lysosomal storage disease caused by deficiency in N-sulfoglucosamine sulfohydrolase (SGSH). Genome-wide gene expression microarrays in MPS IIIA mice detected broad molecular abnormalities (greater tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbece22775897c45c405243868457e2e
https://pubmed.ncbi.nlm.nih.gov/25592334
https://pubmed.ncbi.nlm.nih.gov/25592334
Autor:
Aaron S. Meadows, F. Jason Duncan, Haiyan Fu, Bartholomew J. Naughton, Tierra Ware, Darren A. Murrey, Douglas M. McCarty
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80142 (2013)
PLoS ONE
PLoS ONE
Mucopolysaccharidosis (MPS) IIIB is a devastating neuropathic lysosomal storage disease with complex pathology. This study identifies molecular signatures in peripheral blood that may be relevant to MPS IIIB pathogenesis using a mouse model. Genome-w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae5873a89e10114500b1b96f887cea0
http://europepmc.org/articles/PMC3836978?pdf=render
http://europepmc.org/articles/PMC3836978?pdf=render
Autor:
Douglas M. McCarty, Ricardo J. Pineda, Kathryn Waligura, Darren A. Murrey, Haiyan Fu, Aaron S. Meadows, Marybeth Camboni
Publikováno v:
Molecular Therapy. 24:S64
Mucopolysaccharidosis (MPS) I is a lysosomal storage disease caused by autosomal recessive defect in iduronidase (IDUA). The lack of IDUA activity results in the accumulation of GAGs in cells in virtually all organs, leading to profound somatic and n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::728d6dd9b02d4d1e8a4e37a7fe542a93
https://doi.org/10.1016/s1525-0016(16)32971-9
https://doi.org/10.1016/s1525-0016(16)32971-9
Autor:
Darren A. Murrey, David B. Knaff, Delphine G. Bernard, Vincent Corvest, Patrice Hamel, Bernard Guiard
Publikováno v:
Genetics. 186(2)
The electron transport chains in the membranes of bacteria and organelles generate proton-motive force essential for ATP production. The c-type cytochromes, defined by the covalent attachment of heme to a CXXCH motif, are key electron carriers in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209923cb9afc79dcb93a5071ea70d30e
https://pubmed.ncbi.nlm.nih.gov/20697122
https://pubmed.ncbi.nlm.nih.gov/20697122