Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Darren A Yuen"'
Publikováno v:
Canadian Journal of Kidney Health and Disease, Vol 1 (2014)
Purpose of review: Chronic kidney disease affects approximately 3 million Canadians. Ongoing investment in high quality kidney research is needed to improve the care of patients with kidney disease. The barriers to translating such research are discu
Externí odkaz:
https://doaj.org/article/4e5512cc0d54493abf76c6d1053ccb7e
Autor:
Li-Hao Chen, Suzanne L Advani, Kerri Thai, M Golam Kabir, Manish M Sood, Ian W Gibson, Darren A Yuen, Kim A Connelly, Philip A Marsden, Darren J Kelly, Richard E Gilbert, Andrew Advani
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92227 (2014)
The progressive decline of renal function in chronic kidney disease (CKD) is characterized by both disruption of the microvascular architecture and the accumulation of fibrotic matrix. One angiogenic pathway recently identified as playing an essentia
Externí odkaz:
https://doaj.org/article/512a27c8bad64906a8763177ff40c448
Autor:
Andrew Advani, Kim A Connelly, Darren A Yuen, Yanling Zhang, Suzanne L Advani, Judy Trogadis, M Golam Kabir, Etai Shachar, Michael A Kuliszewski, Howard Leong-Poi, Duncan J Stewart, Richard E Gilbert
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e24695 (2011)
Rarefaction of the renal microvasculature correlates with declining kidney function. However, current technologies commonly used for its evaluation are limited by their reliance on endothelial cell antigen expression and assessment in two dimensions.
Externí odkaz:
https://doaj.org/article/cf75e6c10b094397a793ced8b01c090b
Autor:
Darren A Yuen, Kim A Connelly, Andrew Advani, Christine Liao, Michael A Kuliszewski, Judy Trogadis, Kerri Thai, Suzanne L Advani, Yuan Zhang, Darren J Kelly, Howard Leong-Poi, Armand Keating, Philip A Marsden, Duncan J Stewart, Richard E Gilbert
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9543 (2010)
Most forms of chronic kidney disease are characterized by progressive renal and cardiac fibrosis leading to dysfunction. Preliminary evidence suggests that various bone marrow-derived cell populations have antifibrotic effects. In exploring the thera
Externí odkaz:
https://doaj.org/article/f14bb194dce842eda83c2aee629a46f4
Autor:
Kevin Yau, Alexandra Kurtesi, Freda Qi, Melanie Delgado-Brand, Tulunay R. Tursun, Queenie Hu, Miten Dhruve, Christopher Kandel, Omosomi Enilama, Adeera Levin, Yidi Jiang, W. Rod Hardy, Darren A. Yuen, Jeffrey Perl, Christopher T. Chan, Jerome A. Leis, Matthew J. Oliver, Karen Colwill, Anne-Claude Gingras, Michelle A. Hladunewich
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-8 (2023)
Abstract Neutralization of Omicron subvariants by different bivalent vaccines has not been well evaluated. This study characterizes neutralization against Omicron subvariants in 98 individuals on dialysis or with a kidney transplant receiving the BNT
Externí odkaz:
https://doaj.org/article/65e517f6293b477ba717d5a35a58d87f
Autor:
Caitríona M. McEvoy, MB, BCh, PhD, Queenie Hu, PhD, Kento T. Abe, BSc, Kevin Yau, MD, Matthew J. Oliver, MD, MHS, Adeera Levin, MD, Anne-Claude Gingras, PhD, Michelle A. Hladunewich, MD, MS, Darren A. Yuen, MD, PhD
Publikováno v:
Transplantation Direct, Vol 9, Iss 1, p e1401 (2023)
Background. Kidney transplant recipients (KTRs) have a diminished response to SARS-CoV-2 vaccination compared with immunocompetent individuals. Deeper understanding of antibody responses in KTRs following third-dose vaccination would enable identific
Externí odkaz:
https://doaj.org/article/db592a32f0a943a89956b9febd899ee1
Autor:
Daniel J. Han, Rukhsana Aslam, Paraish S. Misra, Felix Chiu, Tanvi Ojha, Apu Chowdhury, Carmen K. Chan, Hoon-Ki Sung, Darren A. Yuen, Cynthia T. Luk
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101594- (2022)
Objective: Adipose tissue is a very dynamic metabolic organ that plays an essential role in regulating whole-body glucose homeostasis. Dysfunctional adipose tissue hypertrophy with obesity is associated with fibrosis and type 2 diabetes. Yes-associat
Externí odkaz:
https://doaj.org/article/0cd4e995ce7b4cab97303ebcb9db4249
Autor:
Anwar S. Shatil, MSc, Anish Kirpalani, MASc, Eyesha Younus, PhD, Pascal N. Tyrrell, PhD, Adriana Krizova, MD, Darren A. Yuen, MD, FRCPC, PhD
Publikováno v:
Transplantation Direct, Vol 8, Iss 6, p e1334 (2022)
Background. Organ stiffening can be caused by inflammation and fibrosis, processes that are common causes of transplant kidney dysfunction. Magnetic resonance elastography (MRE) is a contrast-free, noninvasive imaging modality that measures kidney st
Externí odkaz:
https://doaj.org/article/21ba657eccec4e03bebbc7939f4bda07
Autor:
Anan Chen, Luisa Ulloa Severino, Thomas C. Panagiotou, Trevor F. Moraes, Darren A. Yuen, Brigitte D. Lavoie, Andrew Wilde
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
During cell division, the actin cytoskeletal network at both the equatorial contractile ring and cell cortex are known to play a role, but the regulation of γ-actin during cytokinesis is less well understood. Here, the authors show that recruitment
Externí odkaz:
https://doaj.org/article/0a7e937311fe4867849f9a4f60295ef9
Autor:
Xiaolin He, Monica F. Tolosa, Tianzhou Zhang, Santosh Kumar Goru, Luisa Ulloa Severino, Paraish S. Misra, Caitríona M. McEvoy, Lauren Caldwell, Stephen G. Szeto, Feng Gao, Xiaolan Chen, Cassandra Atin, Victoria Ki, Noah Vukosa, Catherine Hu, Johnny Zhang, Christopher Yip, Adriana Krizova, Jeffrey L. Wrana, Darren A. Yuen
Publikováno v:
JCI Insight, Vol 7, Iss 4 (2022)
Fibrotic diseases account for nearly half of all deaths in the developed world. Despite its importance, the pathogenesis of fibrosis remains poorly understood. Recently, the two mechanosensitive transcription cofactors YAP and TAZ have emerged as imp
Externí odkaz:
https://doaj.org/article/4fe66df753c24722aff314855974d52f