Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Darren A N, Cook"'
Autor:
Rachel H. Clare, Catherine Bardelle, Paul Harper, W. David Hong, Ulf Börjesson, Kelly L. Johnston, Matthew Collier, Laura Myhill, Andrew Cassidy, Darren Plant, Helen Plant, Roger Clark, Darren A. N. Cook, Andrew Steven, John Archer, Paul McGillan, Sitthivut Charoensutthivarakul, Jaclyn Bibby, Raman Sharma, Gemma L. Nixon, Barton E. Slatko, Lindsey Cantin, Bo Wu, Joseph Turner, Louise Ford, Kirsty Rich, Mark Wigglesworth, Neil G. Berry, Paul M. O’Neill, Mark J. Taylor, Stephen A. Ward
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Parasitic nematodes causing onchocerciasis and lymphatic filariasis rely on a bacterial endosymbiont, Wolbachia, which is a validated therapeutic target. Here, Clare et al. perform a high-throughput screen of 1.3 million compounds and identify 5 chem
Externí odkaz:
https://doaj.org/article/4cb4bba947a8460babf1f27b9cb22a73
Autor:
Ghaith Aljayyoussi, Hayley E. Tyrer, Louise Ford, Hanna Sjoberg, Nicolas Pionnier, David Waterhouse, Jill Davies, Joanne Gamble, Haelly Metuge, Darren A. N. Cook, Andrew Steven, Raman Sharma, Ana F. Guimaraes, Rachel H. Clare, Andrew Cassidy, Kelly L. Johnston, Laura Myhill, Laura Hayward, Samuel Wanji, Joseph D. Turner, Mark J. Taylor, Stephen A. Ward
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Lymphatic filariasis (LF) and onchocerciasis are priority neglected tropical diseases targeted for elimination. The only safe drug treatment with substantial curative activity against the filarial nematodes responsible for LF (Brugia malayi,
Externí odkaz:
https://doaj.org/article/5458446623e84d6f9b626f860c2cd9e3
Autor:
Joseph D Turner, Nicolas Pionnier, Julio Furlong-Silva, Hanna Sjoberg, Stephen Cross, Alice Halliday, Ana F Guimaraes, Darren A N Cook, Andrew Steven, Nico Van Rooijen, Judith E Allen, Stephen J Jenkins, Mark J Taylor
Publikováno v:
PLoS Pathogens, Vol 14, Iss 3, p e1006949 (2018)
Eosinophils are effectors in immunity to tissue helminths but also induce allergic immunopathology. Mechanisms of eosinophilia in non-mucosal tissues during infection remain unresolved. Here we identify a pivotal function of tissue macrophages (Mϕ)
Externí odkaz:
https://doaj.org/article/89105a4f1ac8479982a358d3bd651ce1
Autor:
Peter J. H. Webborn, Stefan Kavanagh, Andrew Cassidy, Paul M. O'Neill, Rachel H. Clare, Mark J. Taylor, Mark C. Wenlock, Neil G. Berry, W. David Hong, Darren A. N. Cook, Gemma L. Nixon, Stephen A. Ward, Paul McGillan, Suet C. Leung, Kelly L. Johnston, Louise Ford
Publikováno v:
ACS Medicinal Chemistry Letters
Anti-Wolbachia therapy has been identified as a viable treatment for combating filarial diseases. Phenotypic screening revealed a series of pyrazolopyrimidine hits with potent anti-Wolbachia activity. This paper focuses on the exploration of the SAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1c7b92fc3cedccfdd23559470f0ac18
https://doi.org/10.1021/acsmedchemlett.1c00216
https://doi.org/10.1021/acsmedchemlett.1c00216
Autor:
Ghaith Aljayyoussi, Hayley E. Tyrer, Louise Ford, Hanna Sjoberg, Nicolas Pionnier, David Waterhouse, Jill Davies, Joanne Gamble, Haelly Metuge, Darren A. N. Cook, Andrew Steven, Raman Sharma, Ana F. Guimaraes, Rachel H. Clare, Andrew Cassidy, Kelly L. Johnston, Laura Myhill, Laura Hayward, Samuel Wanji, Joseph D. Turner, Mark J. Taylor, Stephen A. Ward
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-1 (2018)
A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
Externí odkaz:
https://doaj.org/article/e385b0ad0b0a47df831e0a685925f5a2
Autor:
Shailja Misra-Bhattacharya, Andrew R. Moorhead, Lisa Sadzewicz, Darren A. N. Cook, Luke J. Tallon, Robin E. Bromley, Wanpen Chaicumpa, Jeremy M. Foster, Joseph D. Turner, Michelle L. Michalski, Andrew Steven, Benjamin C. Sparklin, Nikhil Kumar, Mohammad Behram Khan, Yee Ling Lau, Matthew Chung, Mark J. Taylor, Julie C. Dunning Hotopp, Silvia Libro, Atiporn Saeung, Ramakrishna U. Rao, John S. Mattick, Mohd Shahab
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009838 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 10 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 10 (2021)
The sequence diversity of natural and laboratory populations of Brugia pahangi and Brugia malayi was assessed with Illumina resequencing followed by mapping in order to identify single nucleotide variants and insertions/deletions. In natural and labo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc94a3b2c04ce343662e1516547dbc54
https://archive.lstmed.ac.uk/19338/1/082521_Brugia_Genome_Diversity_Manuscript_clean.pdf
https://archive.lstmed.ac.uk/19338/1/082521_Brugia_Genome_Diversity_Manuscript_clean.pdf
Autor:
Nicholas R Casewell, Darren A N Cook, Simon C Wagstaff, Abdulsalami Nasidi, Nandul Durfa, Wolfgang Wüster, Robert A Harrison
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 4, Iss 10, p e851 (2010)
Snakebite is a significant cause of death and disability in subsistent farming populations of sub-Saharan Africa. Antivenom is the most effective treatment of envenoming and is manufactured from IgG of venom-immunised horses/sheep but, because of com
Externí odkaz:
https://doaj.org/article/dc56633a506a4dcb878f358dc34b0c79
Autor:
Sabine Specht, Thomas W. von Geldern, Kelly L. Johnston, Franziska Lenz, Samuel Wanji, Joseph D. Turner, Nicolas Pionnier, Abdel Jelil Njouendou, Dominique Bloemker, Darren A. N. Cook, Robert A. Carr, Louise Ford, Stephen A. Ward, Mark J. Taylor, Kennan C. Marsh, Marianne Koschel, Hanna T. Sjoberg, Howard E. Morton, Dale J. Kempf, John Archer, Hayley E. Tyrer, Haelly M. Metuge, Fanny Fri Fombad, Ghaith Aljayyoussi, Valerinne C. Chunda, Patrick W. N. Chounna, Rachel H. Clare, Marc P. Hübner, Alexandra Ehrens, Achim Hoerauf, Andrew Steven, Emma A Murphy
Publikováno v:
Science Translational Medicine. 11(483)
There is an urgent global need for a safe macrofilaricide drug to accelerate elimination of the neglected tropical diseases onchocerciasis and lymphatic filariasis. From an anti-infective compound library, the macrolide veterinary antibiotic, tylosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1bf4e4e87aab96ab422a6006d9f9f80
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis
Autor:
Paul M. O'Neill, Edward W. Tate, W. David Hong, Adam P. Roberts, Marc P. Hübner, Peter J. H. Webborn, Mark J. Taylor, Alexandra Ehrens, Stefan J. Frohberger, Dominique Struever, John Archer, Farid Benayoud, Joseph D. Turner, Rachel H. Clare, Achim Hoerauf, Stefan Kavanagh, Fabian Gusovsky, Andrew Steven, Neil G. Berry, Kelly L. Johnston, Ghaith Aljayyoussi, Andrew Cassidy, Remigiusz A. Serwa, Suet C. Leung, Janet Hemingway, Alasdair T. M. Hubbard, Gemma L. Nixon, Amy Siu, Stephen A. Ward, Emma A Murphy, Louise Ford, Li Qie, Motohiro Shiotani, Darren A. N. Cook
Publikováno v:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Onchocerciasis and lymphatic filariasis are two neglected tropical diseases that together affect ∼157 million people and inflict severe disability. Both diseases are caused by parasitic filarial nematodes with elimination efforts constrained by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d971c5d526af7ac9de5fb24d20f2893d
Autor:
W David, Hong, Farid, Benayoud, Gemma L, Nixon, Louise, Ford, Kelly L, Johnston, Rachel H, Clare, Andrew, Cassidy, Darren A N, Cook, Amy, Siu, Motohiro, Shiotani, Peter J H, Webborn, Stefan, Kavanagh, Ghaith, Aljayyoussi, Emma, Murphy, Andrew, Steven, John, Archer, Dominique, Struever, Stefan J, Frohberger, Alexandra, Ehrens, Marc P, Hübner, Achim, Hoerauf, Adam P, Roberts, Alasdair T M, Hubbard, Edward W, Tate, Remigiusz A, Serwa, Suet C, Leung, Li, Qie, Neil G, Berry, Fabian, Gusovsky, Janet, Hemingway, Joseph D, Turner, Mark J, Taylor, Stephen A, Ward, Paul M, O'Neill
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Onchocerciasis (river blindness) and lymphatic filariasis (elephantiasis) are neglected tropical diseases that cause severe disability and affect more than 157 million people globally. Current control efforts are hindered by the lack of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a67afcb9d9f3a9d55bf8c9a97e46c9a1
https://pubmed.ncbi.nlm.nih.gov/30617067
https://pubmed.ncbi.nlm.nih.gov/30617067