A superhydrophobic cone to facilitate the xenomonitoring of filarial parasites, malaria, and trypanosomes using mosquito excreta/feces [version 2; referees: 2 approved]

Autor: Darren A.N. Cook, Nils Pilotte, Corrado Minetti, Steven A. Williams, Lisa J. Reimer

Publikováno v: Gates Open Research, Vol 1 (2018)

Background: Molecular xenomonitoring (MX), the testing of insect vectors for the presence of human pathogens, has the potential to provide a non-invasive and cost-effective method for monitoring the prevalence of disease within a community. Current M

Externí odkaz: https://doaj.org/article/8dfbefe9b0b54ff9b50641388600508c

Brugia malayi microfilariae adhere to human vascular endothelial cells in a C3-dependent manner.

Autor: Jan-Hendrik Schroeder, David McCarthy, Tadge Szestak, Darren A Cook, Mark J Taylor, Alister G Craig, Charlotte Lawson, Rachel A Lawrence

Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 5, p e0005592 (2017)

Brugia malayi causes the human tropical disease, lymphatic filariasis. Microfilariae (Mf) of this nematode live in the bloodstream and are ingested by a feeding mosquito vector. Interestingly, in a remarkable co-evolutionary adaptation, Mf appearance

Externí odkaz: https://doaj.org/article/9b4b011748ea4ba5818f31779a8b99ed

Cytochromes P450 (P450s): A review of the class system with a focus on prokaryotic P450s

Autor: James D, Finnigan, Carl, Young, Darren J, Cook, Simon J, Charnock, Gary W, Black

Publikováno v: Advances in protein chemistry and structural biology. 122

Cytochromes P450 (P450s) are a large superfamily of heme-containing monooxygenases. P450s are found in all Kingdoms of life and exhibit incredible diversity, both at sequence level and also on a biochemical basis. In the majority of cases, P450s can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::30b2d65304f9f32b5c944b1eb6d9b4e7
https://pubmed.ncbi.nlm.nih.gov/32951814

Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination

Autor: James R. Marshall, Darren J. Cook, Peiyuan Yao, Nicholas J. Turner, Kirsty M. Graham, Richard A. M. Duncan, Juan Mangas-Sanchez, Simon J. Charnock, Sarah L. Montgomery, Rachel S. Heath, Ryan B. Palmer, Thomas W. Thorpe, James Finnigan

Publikováno v: Nat Chem
Nature Chemistry
Marshall, J R, Yao, P, Montgomery, S L, Finnigan, J D, Thorpe, T W, Palmer, R B, Mangas-sanchez, J, Duncan, R A M, Heath, R S, Graham, K M, Cook, D J, Charnock, S J & Turner, N J 2020, ' Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination ', Nature Chemistry, vol. 13, no. 2, 0, pp. 140-148 . https://doi.org/10.1038/s41557-020-00606-w

Finding faster and simpler ways to screen protein sequence space to enable the identification of new biocatalysts for asymmetric synthesis remains both a challenge and a rate-limiting step in enzyme discovery. Biocatalytic strategies for the synthesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1ba0c8ce114e8834625e477bf31e90
https://pubmed.ncbi.nlm.nih.gov/33380742

Reactions of Tungsten Alkylidynes with Thionyl Chloride

Autor: David J. Williams, and Andrew J. P. White, Anthony F. Hill, Darren J. Cook, Stephen Anderson, John M. Malget

Publikováno v: Organometallics. 23:2552-2557

The reaction of [W(⋮CR)(CO)2(η-C5H5)] (R = C6H3Me2-2,6) with thionyl chloride provides the metallacyclic alkylidene complex [W(CRSCRS)Cl3(η-C5H5)], while similar treatment of [W(⋮CR)(CO)2{HB(pz)3}]...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9e3cb98650ac865483cc478189aa6e2
https://doi.org/10.1021/om030691i