Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Darren, Plant"'
Autor:
Edward M Vital, Darren Plant, Md Yuzaiful Md Yusof, Zoe Wigston, Antonios Psarras, Adewonuola Alase, Lucy Marie Carter, Julien Bauer, Stephanie Wenlock
Publikováno v:
Lupus Science and Medicine, Vol 11, Iss Suppl 1 (2024)
Externí odkaz:
https://doaj.org/article/279d1ef1cc534650b8bc1950a30850ba
Autor:
Hannah Rowlands, Kirsten Tschapalda, Carolyn Blackett, Delyan Ivanov, Darren Plant, Joseph Shaw, Andrew Thomas, Martin Packer, Laurence Arnold, Geoffrey A. Holdgate
Publikováno v:
SLAS Discovery, Vol 28, Iss 3, Pp 102-110 (2023)
The cellular thermal shift assay (CETSA®) has increasingly been used in early drug discovery to provide a measure of cellular target engagement. Traditionally, CETSA has been employed for bespoke questions with small to medium throughput and has pre
Externí odkaz:
https://doaj.org/article/ad58a2ad53e14749991c8324b2b3f6b8
Autor:
Stephanie F. Ling, Kayode Ogungbenro, Adam S. Darwich, Amirah Binti Mohammad Ariff, Nisha Nair, James Bluett, Ann W. Morgan, John D. Isaacs, Anthony G. Wilson, Kimme L. Hyrich, Anne Barton, Darren Plant
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 702 (2024)
Efficacy to biologics in rheumatoid arthritis (RA) patients is variable and is likely influenced by each patient’s circulating drug levels. Using modelling and simulation, the aim of this study was to investigate whether adalimumab and etanercept b
Externí odkaz:
https://doaj.org/article/a8cfb2e5d9654bdba668ec4bfe031ac5
Autor:
Seema Sharma, Darren Plant, John Bowes, Alex Macgregor, Suzanne Verstappen, Anne Barton, Sebastien Viatte
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-8 (2022)
Abstract Background Haplotypes defined by amino acids at HLA-DRB1 positions 11, 71 and 74 associated with susceptibility to rheumatoid arthritis (RA) are associated with radiological outcome, anti-TNF response and all cause-mortality in RA. RA is ass
Externí odkaz:
https://doaj.org/article/e750aa2d2f6a4498b1bd540f0004738b
Autor:
James I. Robinson, Md Yuzaiful Md Yusof, Vinny Davies, Dawn Wild, Michael Morgan, John C. Taylor, Yasser El-Sherbiny, David L. Morris, Lu Liu, Andy C. Rawstron, Maya H. Buch, Darren Plant, Heather J. Cordell, John D. Isaacs, Ian N. Bruce, Paul Emery, Anne Barton, Timothy J. Vyse, Jennifer H. Barrett, Edward M. Vital, Ann W. Morgan
Publikováno v:
EBioMedicine, Vol 86, Iss , Pp 104343- (2022)
Summary: Background: Rituximab is widely used to treat autoimmunity but clinical response varies. Efficacy is determined by the efficiency of B-cell depletion, which may depend on various Fc gamma receptor (FcγR)-dependent mechanisms. Study of FcγR
Externí odkaz:
https://doaj.org/article/737647859b7c4fa4b27b129f6871d9c8
Autor:
James OIiver, Nisha Nair, Gisela Orozco, Samantha Smith, Kimme L. Hyrich, Ann Morgan, John Isaacs, Anthony G. Wilson, BRAGGSS, Anne Barton, Darren Plant
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-9 (2021)
Abstract Background Despite the success of TNF-inhibitor therapy in rheumatoid arthritis treatment, up to 40% of patients fail to respond adequately. This study aimed to identify transcriptome-based biomarkers of adalimumab response in rheumatoid art
Externí odkaz:
https://doaj.org/article/bbb58074afc94d84ac2543b97fb97e06
Autor:
Mateusz Maciejewski, Caroline Sands, Nisha Nair, Stephanie Ling, Suzanne Verstappen, Kimme Hyrich, Anne Barton, Daniel Ziemek, Matthew R. Lewis, Darren Plant
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
Abstract Methotrexate (MTX) is a common first-line treatment for new-onset rheumatoid arthritis (RA). However, MTX is ineffective for 30–40% of patients and there is no way to know which patients might benefit. Here, we built statistical models bas
Externí odkaz:
https://doaj.org/article/15aaa01033fa4c62b85b8be3ce377903
Autor:
Rachel H. Clare, Catherine Bardelle, Paul Harper, W. David Hong, Ulf Börjesson, Kelly L. Johnston, Matthew Collier, Laura Myhill, Andrew Cassidy, Darren Plant, Helen Plant, Roger Clark, Darren A. N. Cook, Andrew Steven, John Archer, Paul McGillan, Sitthivut Charoensutthivarakul, Jaclyn Bibby, Raman Sharma, Gemma L. Nixon, Barton E. Slatko, Lindsey Cantin, Bo Wu, Joseph Turner, Louise Ford, Kirsty Rich, Mark Wigglesworth, Neil G. Berry, Paul M. O’Neill, Mark J. Taylor, Stephen A. Ward
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Parasitic nematodes causing onchocerciasis and lymphatic filariasis rely on a bacterial endosymbiont, Wolbachia, which is a validated therapeutic target. Here, Clare et al. perform a high-throughput screen of 1.3 million compounds and identify 5 chem
Externí odkaz:
https://doaj.org/article/4cb4bba947a8460babf1f27b9cb22a73
Autor:
Samantha Louise Smith, Sheree Alexander, Nisha Nair, Sebastien Viatte, Stephen Eyre, Kimme L Hyrich, Ann W Morgan, Anthony G Wilson, John D Isaacs, Darren Plant, Anne Barton
Publikováno v:
Annals of the Rheumatic Diseases. 82:611-620
ObjectivesThe inflammatory protein calprotectin (MRP8/14) has been identified as a promising biomarker of treatment response in rheumatoid arthritis (RA). Our aim was to test MRP8/14 as a biomarker of response to tumour necrosis factor (TNF)-inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f8c25242ad51798b9c9fbca3f4f4199
https://doi.org/10.1136/ard-2022-222519
https://doi.org/10.1136/ard-2022-222519
Autor:
Amy P. Webster, Darren Plant, Simone Ecker, Flore Zufferey, Jordana T. Bell, Andrew Feber, Dirk S. Paul, Stephan Beck, Anne Barton, Frances M. K. Williams, Jane Worthington
Publikováno v:
Genome Medicine, Vol 10, Iss 1, Pp 1-12 (2018)
Abstract Background Rheumatoid arthritis is a common autoimmune disorder influenced by both genetic and environmental factors. Epigenome-wide association studies can identify environmentally mediated epigenetic changes such as altered DNA methylation
Externí odkaz:
https://doaj.org/article/32c0c5c3851c446a9a59cd9cd1a9608c