Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Darren, Leahy"'
Autor:
Jessica Proctor, Maria Stadler, Lizette M. Cortes, David Brodsky, Lydia Poisson, Volker Gerdts, Alex I. Smirnov, Tatyana I. Smirnova, Subarna Barua, Darren Leahy, Kenneth W. Beagley, Jonathan M. Harris, Toni Darville, Tobias Käser
Publikováno v:
Vaccines, Vol 12, Iss 4, p 423 (2024)
Chlamydia trachomatis (Ct) infections are the most common sexually transmitted infection (STI). Despite effective antibiotics for Ct, undetected infections or delayed treatment can lead to infertility, ectopic pregnancies, and chronic pelvic pain. Be
Externí odkaz:
https://doaj.org/article/6c30875d9f104f3d9aa594e10beaccc5
Autor:
Darren Leahy, Cameron Grant, Alex Jackson, Alex Duff, Nicholas Tardiota, Jessica Van Haeften, Xingchen Chen, Jonathan M. Peake, Michael D. Kruppa, Eliot T. Smith, David A. Johnson, William B. Lott, Jonathan M. Harris
Publikováno v:
Molecules, Vol 26, Iss 17, p 5344 (2021)
Human neutrophil elastase (HNE) is a uniquely destructive serine protease with the ability to unleash a wave of proteolytic activity by destroying the inhibitors of other proteases. Although this phenomenon forms an important part of the innate immun
Externí odkaz:
https://doaj.org/article/06c08418647744e288d41d3b67a423b3
Autor:
Xingchen Chen, Blake T Riley, Simon J de Veer, David E Hoke, Jessica Van Haeften, Darren Leahy, Joakim E Swedberg, Maria Brattsand, Perry J Hartfield, Ashley M Buckle, Jonathan M Harris
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210842 (2019)
Engagement of an extended β-sheet is a common substrate/inhibitor interaction at the active site of serine proteases and is an important feature of Laskowski mechanism inhibitors that present a substrate-like loop to a target protease. This loop is
Externí odkaz:
https://doaj.org/article/ff0580b312cb47f5b9a6eca710bfcd0a
Autor:
Eliot T. Smith, Michael Kruppa, David A. Johnson, Jessica Van Haeften, Xingchen Chen, Darren Leahy, Jonathan Peake, Jonathan M. Harris
Publikováno v:
Protein Expression and Purification. 206:106255
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfd31cc6a2b8b41f0073fde0d10828dd
https://doi.org/10.1016/j.pep.2023.106255
https://doi.org/10.1016/j.pep.2023.106255
Autor:
David A. Johnson, Cameron Grant, Xingchen Chen, Alex Jackson, Eliot T Smith, William B. Lott, Jonathan M. Peake, Alex Duff, Michael D. Kruppa, Darren Leahy, Jonathan M. Harris, Jessica Van Haeften, Nicholas Tardiota
Publikováno v:
Molecules
Volume 26
Issue 17
Molecules, Vol 26, Iss 5344, p 5344 (2021)
Volume 26
Issue 17
Molecules, Vol 26, Iss 5344, p 5344 (2021)
Human neutrophil elastase (HNE) is a uniquely destructive serine protease with the ability to unleash a wave of proteolytic activity by destroying the inhibitors of other proteases. Although this phenomenon forms an important part of the innate immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9168b5096ff4616f8c7247707edcaca
Autor:
Xingchen, Chen, Darren, Leahy, Jessica, Van Haeften, Perry, Hartfield, Peter J, Prentis, Chloé A, van der Burg, Joachim M, Surm, Ana, Pavasovic, Bruno, Madio, Brett R, Hamilton, Glenn F, King, Eivind A B, Undheim, Maria, Brattsand, Jonathan M, Harris
Publikováno v:
Marine Drugs
Serine proteases play pivotal roles in normal physiology and a spectrum of patho-physiological processes. Accordingly, there is considerable interest in the discovery and design of potent serine protease inhibitors for therapeutic applications. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::81867c3d6e88db82a327f14a1ad162f1
https://pubmed.ncbi.nlm.nih.gov/31842369
https://pubmed.ncbi.nlm.nih.gov/31842369
Autor:
Simon J. de Veer, Joakim E. Swedberg, Maria Brattsand, Darren Leahy, Jessica Van Haeften, Jonathan M. Harris, David E. Hoke, Ashley M. Buckle, Blake T. Riley, Xingchen Chen, Perry J. Hartfield
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210842 (2019)
PLoS ONE
PLoS ONE
Engagement of an extended beta-sheet is a common substrate/inhibitor interaction at the active site of serine proteases and is an important feature of Laskowski mechanism inhibitors that present a substrate-like loop to a target protease. This loop i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0e3d8a97e95564d51892639bc3a3af9
https://doaj.org/article/ff0580b312cb47f5b9a6eca710bfcd0a
https://doaj.org/article/ff0580b312cb47f5b9a6eca710bfcd0a
Autor:
Peter J. Prentis, Maria Brattsand, Eivind A. B. Undheim, Perry J. Hartfield, Glenn F. King, Bruno Madio, Darren Leahy, Jonathan M. Harris, Chloé A. van der Burg, Brett Hamilton, Jessica Van Haeften, Joachim M. Surm, Xingchen Chen, Ana Pavasovic
Publikováno v:
Marine Drugs
Volume 17
Issue 12
Volume 17
Issue 12
Serine proteases play pivotal roles in normal physiology and a spectrum of patho-physiological processes. Accordingly, there is considerable interest in the discovery and design of potent serine protease inhibitors for therapeutic applications. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc50cb334c1c6145d96105598f5e2a8
https://doi.org/10.3390/md17120701
https://doi.org/10.3390/md17120701