SARS-COV-2 recombinant Receptor-Binding-Domain (RBD) induces neutralizing antibodies against variant strains of SARS-CoV-2 and SARS-CoV-1

Autor: Kanti Pabbaraju, Matthew A. Croxen, Holly A. Saffran, Kevin Crawford, Michael Logan, Gerald LaChance, Darren Hockman, John Lok Man Law, D. Lorne Tyrrell, Abdolamir Landi, Janelle Johnson, Graham Tipples, Raelynn Brassard, Justin Shields, Eve Hobart, Michael Houghton, M. Joanne Lemieux, Michael A. Joyce, Elena Arutyunova

Publikováno v: Vaccine

SARS-CoV-2 is the etiological agent of COVID19. There are currently several licensed vaccines approved for human use and most of them are targeting the spike protein (or virion) in the virion envelope to induce protective immunity. Recently, variants

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e103c5c330664243455b4cc9fc1daec9
https://doi.org/10.1016/j.vaccine.2021.08.081

Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and

Autor: Bing, Bai, Alexandr, Belovodskiy, Mostofa, Hena, Appan Srinivas, Kandadai, Michael A, Joyce, Holly A, Saffran, Justin A, Shields, Muhammad Bashir, Khan, Elena, Arutyunova, Jimmy, Lu, Sardeev K, Bajwa, Darren, Hockman, Conrad, Fischer, Tess, Lamer, Wayne, Vuong, Marco J, van Belkum, Zhengxian, Gu, Fusen, Lin, Yanhua, Du, Jia, Xu, Mohammad, Rahim, Howard S, Young, John C, Vederas, D Lorne, Tyrrell, M Joanne, Lemieux, James A, Nieman

Publikováno v: Journal of Medicinal Chemistry

Recurring coronavirus outbreaks, such as the current COVID-19 pandemic, establish a necessity to develop direct-acting antivirals that can be readily administered and are active against a broad spectrum of coronaviruses. Described in this Article are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1ba0e09460619e979a4ea92d8978fe08
https://pubmed.ncbi.nlm.nih.gov/34242027

A hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humans.

Autor: John Lok Man Law, Chao Chen, Jason Wong, Darren Hockman, Deanna M Santer, Sharon E Frey, Robert B Belshe, Takaji Wakita, Jens Bukh, Christopher T Jones, Charles M Rice, Sergio Abrignani, D Lorne Tyrrell, Michael Houghton

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e59776 (2013)

Although a cure for HCV is on the near horizon, emerging drug cocktails will be expensive, associated with side-effects and resistance making a global vaccine an urgent priority given the estimated high incidence of infection around the world. Due to

Externí odkaz: https://doaj.org/article/79f80c8f3d334a15841ec258bb18caa6

A Recombinant Hepatitis C Virus Genotype 1a E1/E2 Envelope Glycoprotein Vaccine Elicits Antibodies That Differentially Neutralize Closely Related 2a Strains through Interactions of the N-Terminal Hypervariable Region 1 of E2 with Scavenger Receptor B1

Autor: Janelle Johnson, Darren Hockman, John Lok Man Law, Michael Houghton, D. Lorne Tyrrell, Jason Wong, Holly Freedman, Michael R. Beard, Jianqi He, Thomas F. Baumert, Chao Chen, Michael Logan, Nicholas S. Eyre

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2019, 93 (22), ⟨10.1128/JVI.00810-19⟩
Journal of Virology, 2019, 93 (22), pp.e00810-19. ⟨10.1128/JVI.00810-19⟩

A vaccine is still urgently needed to overcome the hepatitis C virus (HCV) epidemic. It is estimated that 1.75 million new HCV infections occur each year, many of which will go undiagnosed and untreated. Untreated HCV can lead to continued spread of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9ed9610396a2092674556b7c486488
https://hal.archives-ouvertes.fr/hal-02385651

Effect of Different Adjuvants on the Longevity and Strength of Humoral and Cellular Immune Responses to the HCV Envelope Glycoproteins

Autor: John Lok Man Law, D. Lorne Tyrrell, Michael Logan, Bassel Akache, Darren Hockman, Juthika Kundu, Blair A. Harrison, Felicity C. Stark, Lise Deschatelets, Renu Dudani, Amir Landi, Michael J McCluskie, Lakshmi Krishnan, Yimei Jia, Michael Houghton

Publikováno v: Vaccines
Volume 7
Issue 4

Infection by Hepatitis C virus (HCV) can lead to liver cirrhosis/hepatocellular carcinoma and remains a major cause of serious disease morbidity and mortality worldwide. However, current treatment regimens remain inaccessible to most patients, partic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fbdd8b7ad6e583b1b527f5df2411122
https://doi.org/10.3390/vaccines7040204