Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Darren, Chambers"'
Autor:
Dominic Scaglioni, Francesco Catapano, Matthew Ellis, Silvia Torelli, Darren Chambers, Lucy Feng, Matthew Beck, Caroline Sewry, Mauro Monforte, Shawn Harriman, Erica Koenig, Jyoti Malhotra, Linda Popplewell, Michela Guglieri, Volker Straub, Eugenio Mercuri, Laurent Servais, Rahul Phadke, Jennifer Morgan, Francesco Muntoni
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-17 (2021)
Abstract During the last decade, multiple clinical trials for Duchenne muscular dystrophy (DMD) have focused on the induction of dystrophin expression using different strategies. Many of these trials have reported a clear increase in dystrophin prote
Externí odkaz:
https://doaj.org/article/0bb99a8919a34521a7b32c5a0a245087
Autor:
Giuseppa Piras, Claudia Montiel-Equihua, Yee-Ka Agnes Chan, Slawomir Wantuch, Daniel Stuckey, Derek Burke, Helen Prunty, Rahul Phadke, Darren Chambers, Armando Partida-Gaytan, Diego Leon-Rico, Neelam Panchal, Kathryn Whitmore, Miguel Calero, Sara Benedetti, Giorgia Santilli, Adrian J. Thrasher, H. Bobby Gaspar
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 558-570 (2020)
Pompe disease is a lysosomal storage disorder caused by malfunctions of the acid alpha-glucosidase (GAA) enzyme with a consequent toxic accumulation of glycogen in cells. Muscle wasting and hypertrophic cardiomyopathy are the most common clinical sig
Externí odkaz:
https://doaj.org/article/228a291921bd422d9b985ca08e819866
Autor:
Dominic Scaglioni, Matthew Ellis, Francesco Catapano, Silvia Torelli, Darren Chambers, Lucy Feng, Caroline Sewry, Jennifer Morgan, Francesco Muntoni, Rahul Phadke
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-16 (2020)
Abstract The primary molecular endpoint for many Duchenne muscular dystrophy (DMD) clinical trials is the induction, or increase in production, of dystrophin protein in striated muscle. For accurate endpoint analysis, it is essential to have reliable
Externí odkaz:
https://doaj.org/article/043c3f49a55448e78a0c3e63f080d8bb
Autor:
Valentina Sardone, Matthew Ellis, Silvia Torelli, Lucy Feng, Darren Chambers, Deborah Eastwood, Caroline Sewry, Rahul Phadke, Jennifer E Morgan, Francesco Muntoni
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194540 (2018)
Clinical trials using strategies aimed at inducing dystrophin expression in Duchenne muscular dystrophy (DMD) are underway or at advanced planning stage, including splice switching antisense oligonucleotides (AON), drugs to induce read-through of non
Externí odkaz:
https://doaj.org/article/cb7c92cc16454711a4912773fe14b1a9
Somatic SNCA Copy Number Variants in Multiple System Atrophy Are Related to Pathology and Inclusions
Autor:
Monica Emili Garcia‐Segura, Diego Perez‐Rodriguez, Darren Chambers, Zane Jaunmuktane, Christos Proukakis
Publikováno v:
Movement disorders : official journal of the Movement Disorder SocietyReferences.
Somatic α-synuclein (SNCA) copy number variants (CNVs, specifically gains) occur in multiple system atrophy (MSA) and Parkinson's disease brains.The aim was to compare somatic SNCA CNVs in MSA subtypes (striatonigral degeneration [SND] and olivopont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d5a178f647bbda9e0a98b3e027ae0b
https://pubmed.ncbi.nlm.nih.gov/36448620
https://pubmed.ncbi.nlm.nih.gov/36448620
Autor:
Neil E Hill, Kevin G Murphy, Saima Saeed, Rahul Phadke, Darren Chambers, Duncan R Wilson, Stephen J Brett, Mervyn Singer
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182659 (2017)
Patients with multiple injuries or sepsis requiring intensive care treatment invariably develop a catabolic state with resultant loss of lean body mass, for which there are currently no effective treatments. Recovery can take months and mortality is
Externí odkaz:
https://doaj.org/article/e60d4776e41c4c01aabb3d6ed692562c
Autor:
Valentina, Sardone, Matthew, Ellis, Silvia, Torelli, Lucy, Feng, Darren, Chambers, Deborah, Eastwood, Caroline, Sewry, Rahul, Phadke, Jennifer E, Morgan, Francesco, Muntoni
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194540 (2018)
PLoS ONE
PLoS ONE
Clinical trials using strategies aimed at inducing dystrophin expression in Duchenne muscular dystrophy (DMD) are underway or at advanced planning stage, including splice switching antisense oligonucleotides (AON), drugs to induce read-through of non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::716df25050b878ef30c7832c1a0bc1ee
https://eprints.soton.ac.uk/428175/
https://eprints.soton.ac.uk/428175/
Autor:
Jason Buckton1, Darren Chambers2, Mike Cullen3, Andre Gardner4, Gareth Martin1, Nothard, Simon1
Publikováno v:
Horticulture Week. 10/30/2015 Supplement What kit? Update, p12-14. 3p.