Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Darren, Boehning"'
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Calcium influx through plasma membrane ion channels is crucial for many events in cellular physiology. Cell surface stimuli lead to the production of inositol 1,4,5-trisphosphate (IP3), which binds to IP3 receptors (IP3R) in the endoplasmic reticulum
Externí odkaz:
https://doaj.org/article/bd8a35e06343447c9f07379db6addf1e
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
S-acylation, the reversible lipidation of free cysteine residues with long-chain fatty acids, is a highly dynamic post-translational protein modification that has recently emerged as an important regulator of the T cell function. The reversible natur
Externí odkaz:
https://doaj.org/article/13a3f8c5f9d34ab9a3939129748fb586
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Protein S-acylation is the reversible addition of fatty acids to the cysteine residues of target proteins. It regulates multiple aspects of protein function, including the localization to membranes, intracellular trafficking, protein interactions, pr
Externí odkaz:
https://doaj.org/article/bf63017c0387478cb3b89340b80f1736
Autor:
Alexander Andersohn, M. Iveth Garcia, Ying Fan, Max C. Thompson, Askar M. Akimzhanov, Abdikarim Abdullahi, Marc G. Jeschke, Darren Boehning
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Chronic ER stress occurs when protein misfolding in the Endoplasmic reticulum (ER) lumen remains unresolved despite activation of the unfolded protein response. We have shown that traumatic injury such as a severe burn leads to chronic ER stress in v
Externí odkaz:
https://doaj.org/article/5cbebce8c3ec407f89f23bcb19ebc8a2
Autor:
Jessica J. Chen, Darren Boehning
Publikováno v:
Frontiers in Oncology, Vol 7 (2017)
Calcium is a critical regulator of cell death pathways. One of the most proximal events leading to cell death is activation of plasma membrane and endoplasmic reticulum-resident calcium channels. A large body of evidence indicates that defects in thi
Externí odkaz:
https://doaj.org/article/f6827e71ae42491d8e17dd3c3b3febd9
Autor:
Natasha C. Brooks, Alexandra H. Marshall, Nour Qa’aty, Yaeko Hiyama, Darren Boehning, Marc G. Jeschke
Publikováno v:
Molecular Medicine, Vol 19, Iss 1, Pp 72-78 (2013)
Abstract The first 24 h following burn injury is known as the ebb phase and is characterized by a depressed metabolic rate. While the postburn ebb phase has been well described, the molecular mechanisms underlying this response are poorly understood.
Externí odkaz:
https://doaj.org/article/dc9698236d0844f1b8a1d5d5736ed4a4
Publikováno v:
Mol Biol Rep
S-acylation – reversible post-translational lipidation of cysteine residues – is emerging as an important regulatory mechanism in T cell signaling. Dynamic S-acylation is critical for protein recruitment into the T cell receptor complex and initi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a7dcffc24b2b24fcb6ab357713cbd5
https://doi.org/10.1007/s11033-020-05691-1
https://doi.org/10.1007/s11033-020-05691-1
Autor:
Goutham Kodkandla, Savannah J West, Qiaochu Wang, Ritika Tewari, Michael X. Zhu, Askar M. Akimzhanov, Darren Boehning
Many cell surface stimuli cause calcium release from endoplasmic reticulum (ER) stores to regulate cellular physiology. Upon ER calcium store depletion, the ER-resident protein STIM1 physically interacts with plasma membrane protein Orai1 to induce c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c6de8fe0abc0ae479256b3d5bad27b3
https://doi.org/10.1101/2022.02.15.480522
https://doi.org/10.1101/2022.02.15.480522
Autor:
Goutham, Kodakandla, Savannah J, West, Qiaochu, Wang, Ritika, Tewari, Michael X, Zhu, Askar M, Akimzhanov, Darren, Boehning
Publikováno v:
The Journal of biological chemistry. 298(9)
Many cell surface stimuli cause calcium release from endoplasmic reticulum (ER) stores to regulate cellular physiology. Upon ER calcium store depletion, the ER-resident protein stromal interaction molecule 1 (STIM1) physically interacts with plasma m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd0a18b25924fa38bbc808448381bf2a
https://pubmed.ncbi.nlm.nih.gov/35934052
https://pubmed.ncbi.nlm.nih.gov/35934052
Autor:
Juquan Song, Xiao-jun Zhang, Darren Boehning, Natasha C. Brooks, David N. Herndon, Marc G. Jeschke
Publikováno v:
International Journal of Biological Sciences, Vol 8, Iss 2, Pp 265-271 (2012)
Severe burn-induced liver damage and dysfunction is associated with endoplasmic reticulum (ER) stress. ER stress has been shown to regulate global protein synthesis. In the current study, we induced ER stress in vitro and estimated the effect of ER s
Externí odkaz:
https://doaj.org/article/780b6793ef2a48eb84b17ad73ef73826