Výsledky vyhledávání - "Darrell R Smith"

Akademický článek

Sensory Neurons Derived from Diabetic Rats Have Diminished Internal Ca Stores Linked to Impaired Re-uptake by the Endoplasmic Reticulum

Autor: Elena Zherebitskaya, Jason Schapansky, Eli Akude, Darrell R Smith, Randy Van der Ploeg, Natasha Solovyova, Alexei Verkhratsky, Paul Fernyhough

Publikováno v: ASN Neuro, Vol 4 (2011)

Distal symmetrical sensory neuropathy in diabetes involves the dying back of axons, and the pathology equates with axonal dystrophy generated under conditions of aberrant Ca 2+ signalling. Previous work has described abnormalities in Ca 2+ homoeostas

Externí odkaz: https://doaj.org/article/f082142f950145fd9bb5f4bdade76ad6

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Akademický článek

Sensory neurons derived from diabetic rats exhibit deficits in functional glycolysis and ATP that are ameliorated by IGF-1

Autor: Mohamad-Reza Aghanoori, Vicky Margulets, Darrell R. Smith, Lorrie A. Kirshenbaum, Daniel Gitler, Paul Fernyhough

Publikováno v: Molecular Metabolism, Vol 49, Iss , Pp 101191- (2021)

Objective: The distal dying-back of the longest nerve fibres is a hallmark of diabetic neuropathy, and impaired provision of energy in the form of adenosine triphosphate (ATP) may contribute to this neurodegenerative process. We hypothesised that ene

Externí odkaz: https://doaj.org/article/79dd1362964d46b197d74b86ae530902

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Akademický článek

The role of aberrant mitochondrial bioenergetics in diabetic neuropathy

Autor: Subir K. Roy Chowdhury, Darrell R. Smith, Paul Fernyhough

Publikováno v: Neurobiology of Disease, Vol 51, Iss , Pp 56-65 (2013)

Diabetic neuropathy is a neurological complication of diabetes that causes significant morbidity and, because of the obesity-driven rise in incidence of type 2 diabetes, is becoming a major international health problem. Mitochondrial phenotype is abn

Externí odkaz: https://doaj.org/article/dfa84894f884404da124308de50399d3

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Muscarinic Toxin 7 Signals Via Ca2+/Calmodulin-Dependent Protein Kinase Kinase β to Augment Mitochondrial Function and Prevent Neurodegeneration

Autor: Mohammad Golam Sabbir, Jennifer Brown, Darrell R. Smith, Markos Z Kassahun, Lori Tessler, Paul Fernyhough, Ali Saleh, Mohamad-Reza Aghanoori, Katie E. Frizzi, Nigel A. Calcutt, Subir K. Roy Chowdhury, Eva Gedarevich

Publikováno v: Molecular neurobiology, vol 57, iss 6
Molecular Neurobiology

Mitochondrial dysfunction is implicated in a variety of neurodegenerative diseases of the nervous system. Peroxisome proliferator–activated receptor-γ coactivator-1α (PGC-1α) is a regulator of mitochondrial function in multiple cell types. In se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baae44ad3d333e93bafb0c92451806eb
https://doi.org/10.1007/s12035-020-01900-x

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CEBPβ regulation of endogenous IGF-1 in adult sensory neurons can be mobilized to overcome diabetes-induced deficits in bioenergetics and axonal outgrowth

Autor: Mohamad-Reza Aghanoori, Prasoon Agarwal, Evan Gauvin, Raghu S. Nagalingam, Raiza Bonomo, Vinith Yathindranath, Darrell R. Smith, Yan Hai, Samantha Lee, Corinne G. Jolivalt, Nigel A. Calcutt, Meaghan J. Jones, Michael P. Czubryt, Donald W. Miller, Vernon W. Dolinsky, Virginie Mansuy-Aubert, Paul Fernyhough

Publikováno v: Cellular and Molecular Life Sciences. 79

Aberrant insulin-like growth factor 1 (IGF-1) signaling has been proposed as a contributing factor to the development of neurodegenerative disorders including diabetic neuropathy, and delivery of exogenous IGF-1 has been explored as a treatment for A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8ecc9c94a3f8edc5f54610fe114420
https://doi.org/10.1007/s00018-022-04201-9

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Depressed mitochondrial function and electron transport Complex II-mediated H 2 O 2 production in the cortex of type 1 diabetic rodents

Autor: Paul Fernyhough, Benedict C. Albensi, Ella Thomson, Darrell R. Smith, Jelena Djordjevic, Subir K. Roy Chowdhury

Publikováno v: Molecular and Cellular Neuroscience. 90:49-59

Aims Abnormalities in mitochondrial function under diabetic conditions can lead to deficits in function of cortical neurons and their support cells exhibiting a pivotal role in the pathogenesis of several neurodegenerative disorders, including Alzhei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::286ac70733a277331d410cbf498f911e
https://doi.org/10.1016/j.mcn.2018.05.006

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Insulin-like growth factor-1 activates AMPK to augment mitochondrial function and correct neuronal metabolism in sensory neurons in type 1 diabetes

Autor: Paul Fernyhough, Xiajun Zhou, Carlos H.A. Jesus, Andrew Ajisebutu, Mohamad-Reza Aghanoori, Nigel A. Calcutt, Shiva Shariati-Ievari, Michel Aliani, Darrell R. Smith, Annee Nguyen, Fiona Desmond

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 20, Iss, Pp 149-165 (2019)

Objective Diabetic sensorimotor polyneuropathy (DSPN) affects approximately half of diabetic patients leading to significant morbidity. There is impaired neurotrophic growth factor signaling, AMP-activated protein kinase (AMPK) activity and mitochond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce6018142ffca8c0aa230a4ba5fc070
https://escholarship.org/uc/item/46b6b0dp

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Sensory neurons derived from diabetic rats exhibit deficits in functional glycolysis and ATP that are ameliorated by IGF-1

Autor: Paul Fernyhough, Mohamad-Reza Aghanoori, Darrell R. Smith, Lorrie A. Kirshenbaum, Daniel Gitler, Vicky Margulets

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 49, Iss, Pp 101191-(2021)

Objective The distal dying-back of the longest nerve fibres is a hallmark of diabetic neuropathy, and impaired provision of energy in the form of adenosine triphosphate (ATP) may contribute to this neurodegenerative process. We hypothesised that ener

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e002f106a97d4db372f3c30c73d7ea2
https://doi.org/10.1016/j.molmet.2021.101191

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IGF‐1 Optimizes Mitochondrial Function Through AMP‐Activated Protein Kinase in Adult Sensory Neurons

Autor: Darrell R. Smith, Paul Fernyhough, Mohamad-Reza Aghanoori, Mohammad Golam Sabbir

Publikováno v: The FASEB Journal. 32

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7001d4c793892269631feefdbd191dff
https://doi.org/10.1096/fasebj.2018.32.1_supplement.533.42

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Depressed mitochondrial function and electron transport Complex II-mediated H

Autor: Subir, Roy Chowdhury, Jelena, Djordjevic, Ella, Thomson, Darrell R, Smith, Benedict C, Albensi, Paul, Fernyhough

Publikováno v: Molecular and cellular neurosciences. 90

Abnormalities in mitochondrial function under diabetic conditions can lead to deficits in function of cortical neurons and their support cells exhibiting a pivotal role in the pathogenesis of several neurodegenerative disorders, including Alzheimer's

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b2bef36f50094a71f24c14e0f99d3618
https://pubmed.ncbi.nlm.nih.gov/29802939

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