Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Darrell D. Bigner"'
Autor:
Paul A. Northcott, Hai Yan, Timothy E. Van Meter, James T. Rutka, Yukiko Nakahara, Meihua Li, Paul Kongkham, Sidney Croul, Darrell D. Bigner, Wesia Grajkowska, Christian A. Smith, Michael D. Taylor, Young Shin Ra, Annie Huang, Charles G. Eberhart
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 1, Pp 20-27 (2010)
Although medulloblastoma is the most common pediatric malignant brain tumor, its molecular underpinnings are largely unknown. We have identified rare, recurrent homozygous deletions of Kruppel-like Factor 4 (KLF4) in medulloblastoma using high-resolu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f15240153c7f83d7da1d72e90bd535
Autor:
Sandy Aronson, Leslie Cope, Michael L. Bittner, Daniel C. Koboldt, Alex E. Lash, W. K. Alfred Yung, Margaret Morgan, Devin Absher, Carl F. Schaefer, Roger E. McLendon, Michael D. Prados, Josh Gould, Ju Han, Stacey Gabriel, Scott R. VandenBerg, Ilana Perna, Troy Shelton, Junyuan Wu, Sacha Scott, Steve Scherer, Michael J. T. O’Kelly, Li Ding, Erin Hickey, Elizabeth J. Thomson, Bahram Parvin, Kim D. Delehaunty, Gi Choi Yoon, Mark D. Robinson, Oliver Bogler, Darrell D. Bigner, Michael R. Reich, Jianhua Zhang, Robert S. Fulton, Allan H. Friedman, Tammi L. Vickery, Amita Aggarwal, Subhashree Madhavan, Liuda Ziaugra, Yuan Qi, Vandita Joshi, Eric Van Name, Jane Wilkinson, W. Ruprecht Wiedemeyer, Xiaoqi Shi, Richard A. Gibbs, Lynda Chin, Jessica Chen, Stefano Monti, Erwin G. Van Meir, John Ngai, Amy Hawkins, Elizabeth Lenkiewicz, Brad Ozenberger, Shannon Dorton, Georgia Ren, John N. Weinstein, Gena M. Mastrogianakis, Asif T. Chinwalla, Scott L. Carter, Nicholas D. Socci, Rachel Abbott, Gavin Sherlock, Lucinda Fulton, Hyun Soo Kim, Fei Pan, Magali Cavatore, Gabriele Alexe, Francis S. Collins, Narayanan Sathiamoorthy, Lakshmi Jakkula, Brian H. Dunford-Shore, Jireh Santibanez, Tom Mikkelsen, Huy V. Nguyen, Levi A. Garraway, Christopher A. Miller, Jinghui Zhang, Ken Chen, Timothy Fennell, Robert Sfeir, James A. Robinson, Alexey Stukalov, Richard K. Wilson, Matthew Meyerson, Daniel J. Weisenberger, Mi Yi Joo, Yevgeniy Antipin, Anna Lapuk, Gerald V. Fontenay, Nicolas Stransky, Adam B. Olshen, Elizabeth Purdom, Josh Korn, Huyen Dinh, Sai Balu, Victoria Wang, James G. Herman, Christie Kovar, Kristian Cibulskis, Tisha Chung, Agnes Viale, Paul T. Spellman, Supriya Gupta, Melissa Parkin, Peter J. Park, Maddy Wiechert, John W. Wallis, Peter W. Laird, Nikolaus Schultz, James D. Brooks, David Nassau, Jun Li, John R. Osborne, Anna D. Barker, Peter Fielding, Boris Reva, Karen Vranizan, D. Neil Hayes, Aleksandar Milosavljevic, Lawrence A. Donehower, Won Kong Sek, Daniela S. Gerhard, Otis Hall, Rameen Beroukhim, Audrey Southwick, George M. Weinstock, Chris Markovic, Roel G.W. Verhaak, David Van Den Berg, Joe W. Gray, Yanru Ren, Ethan Cerami, Yiming Zhu, Amrita Ray, Yonghong Xiao, Kristin G. Ardlie, William L. Gerald, Michael S. Lawrence, Gerald R. Fowler, Mark S. Guyer, Isaac S. Kohane, Kornel E. Schuebel, Mitchel S. Berger, Jeffrey J. Olson, Gary W. Swift, Lora Lewis, Sheri Sanders, Norman L. Lehman, Eric S. Lander, Robert Penny, Liliana Villafania, John G. Conboy, Ari B. Kahn, Henry Marr, Heidi S. Feiler, Lynn Nazareth, David J. Dooling, Katherine A. Hoadley, Alicia Hawes, Marc Ladanyi, Aniko Sabo, Wendy Winckler, Vivian Peng, Barbara A. Weir, Daniel J. Brat, Scott Morris, Carolyn C. Compton, Todd R. Golub, Scott Abbott, Michael D. McLellan, Jiqiang Yao, Shalini N. Jhangiani, Michael D. Topal, Michael C. Wendl, Gad Getz, Jun Yao, Derek Y. Chiang, Larry Feng, Steffen Durinck, David A. Wheeler, Yuzhu Tang, Benjamin Gross, Barry S. Taylor, Kenneth Aldape, Craig Pohl, Rick Meyer, Peter J. Good, Ling Lin, Elaine R. Mardis, Robert C. Onofrio, Jane Peterson, Stephen B. Baylin, Li-Xuan Qin, Andrew Cree, Cameron Brennan, Charles M. Perou, William Courtney, Omar Alvi, Donna M. Muzny, Joseph G. Vockley, Jill P. Mesirov, Yan Shi, Alexei Protopopov, Jim Vaught, Craig H. Mermel, Scott Mahan, Laetitia Borsu, Heather Schmidt, Jennifer Baldwin, Tracie L. Miner, Toby Bloom, David E. Larson, Leander Van Neste, Nicholas J. Wang, Kenneth H. Buetow, Raju Kucherlapati, Anthony San Lucas, Martin L. Ferguson, Terence P. Speed, Venkatraman E. Seshan, Debbie Beasley, Carrie Sougnez, Carrie A. Haipek, Richard M. Myers, Chris Sander, Qing Wang Wei, Jon G. Seidman, Rob Nicol, Manuel L. Gonzalez-Garay, Shin Leong, Shannon T. Brady
Publikováno v:
Nature
Nature, 455(7216), 1061-1068. Nature Publishing Group
Nature, 455(7216), 1061-1068. Nature Publishing Group
Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas ( TCGA) pilot project aims to assess the value of large- scale m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2e67c665413cbf7b8234ef50ffe2c1
https://doi.org/10.1038/nature07385
https://doi.org/10.1038/nature07385
Autor:
B S Karen Carter, Stephen T. Keir, Henry S. Friedman, Lee W. Jones, Bebe Guill, Darrell D. Bigner, David A. Reardon
Publikováno v:
Cancer. 106:2224-2232
BACKGROUND Exercise may represent a supportive intervention that may complement existing neurooncologic therapies and address a multitude of therapy-induced debilitating side effects in patients with brain tumors. Given the limited evidence, the auth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234083cd183e97be31063469fd6bfd86
https://doi.org/10.1002/cncr.21858
https://doi.org/10.1002/cncr.21858
Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCδ
Publikováno v:
Cancer Chemotherapy and Pharmacology. 56:585-593
Substance P receptor (SPR), a G protein-coupled receptor (GPCR), is found in human glioblastomas, and has been implicated in their growth. Consistent with a role for SPR in cell growth, activation of SPR in U373 MG human glioblastoma cells leads to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37cffb1f0ca02954bf7ff4e00e4af1c7
https://doi.org/10.1007/s00280-005-1030-3
https://doi.org/10.1007/s00280-005-1030-3
Autor:
Deborah H. Allen, Amy Walker, Jeremy N. Rich, Sandra Tourt-Uhlig, Cindy Bohlin, Allan H. Friedman, John H. Sampson, Susanne Jackson, Mary Lou Affronti, Sridharan Gururangan, Karen Ziegler, James M. Provenzale, Jennifer A. Quinn, Michael A. Badruddoja, James E. Herndon, James J. Vredenburgh, Darrell D. Bigner, David A. Reardon, Steven Silverman, Henry S. Friedman, Jeannette M. Dowell
Publikováno v:
Neuro-Oncology. 6:134-144
In preclinical studies, BCNU, or 1,3-bis(2-chloroethyl)-1-nitrosourea, plus CPT-11 (irinotecan) exhibits schedule-dependent, synergistic activity against malignant glioma (MG). We previously established the maximum tolerated dose of CPT-11 when admin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::660f8c22a6888ddf0a50b9b1a35e3885
https://doi.org/10.1215/s1152851703000413
https://doi.org/10.1215/s1152851703000413
Autor:
Chunhui Di, Lei Han, Tao Jiang, Chunsheng Kang, Liang Zeng, Zhaoshi Bao, Brian E. Fee, Miriam V. Rivas, Darrell D. Bigner, Junxia Zhang, David Cory Adamson, Kailiang Zhang
Summary Aims Down-regulation of AJAP1 in glioblastoma multiforme (GBM) has been reported. However, the expression profiles of AJAP1 in gliomas and the underlying mechanisms of AJAP1 function on invasion are still poorly understood. Methods The gene p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915e4d88ee644385f79bbb7eab92246f
https://europepmc.org/articles/PMC4511491/
https://europepmc.org/articles/PMC4511491/
Autor:
Michael L. Graham, Geoffrey B. Mccowage, Margaret Duncan-Brown, O. Michael Colvin, Joanne Kurtzberg, Roger E. McLendon, Patricia L. Robertson, Gary J. Felsberg, Albert Moghrabi, Herbert E. Fuchs, Barry Golembe, Elizabeth S. Stewart, Henry S. Friedman, Darrell D. Bigner, Robert D. Tien, Lee Ferrell, Tracy Kerby
Publikováno v:
Medical and Pediatric Oncology. 27:32-39
Leptomeningeal dissemination of childhood pilocytic astrocytoma (PA) is a rare event with little information available regarding therapy. We report here four children with disseminated PA whom we treated with high doses of cyclophosphamide with clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10e50a6ec2e5b30a9a5619b7d9359cef
https://doi.org/10.1002/(sici)1096-911x(199607)27:1<32::aid-mpo7>3.0.co
https://doi.org/10.1002/(sici)1096-911x(199607)27:1<32::aid-mpo7>3.0.co
Autor:
Roger E. McLendon, Zachary J. Reitman, Darrell D. Bigner, Hai Yan, Christopher L. Mariani, Matthew Breen, Natasha J. Olby, Rachael Thomas
Human diffuse and anaplastic astrocytomas, well-differenti-ated and anaplastic oligodendrogliomas and secondary glio-blastomas frequently (>70%) contain somatic mutations ofthe R132 codon of the cytoplasmic NADPþ-dependent iso-citrate dehydrogenase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e605f4ee6a14a0c8767955b9423a6e52
https://europepmc.org/articles/PMC3498760/
https://europepmc.org/articles/PMC3498760/
Autor:
Darrell D. Bigner, Dale Ding, John H. Sampson, James E. Herndon, Raghu Raghavan, Thomas J. Cummings, Charles W. Kanaly, Ira Pastan
Publikováno v:
Journal of neuro-oncology. 98(1)
A major obstacle in glioblastoma (GBM) therapy is the restrictive nature of the blood-brain barrier (BBB). Convection-enhanced delivery (CED) is a novel method of drug administration which allows direct parenchymal infusion of therapeutics, bypassing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22aa95b6812674252522acb35862905
https://pubmed.ncbi.nlm.nih.gov/19898744
https://pubmed.ncbi.nlm.nih.gov/19898744
Autor:
Paul A. Northcott, Yukiko Nakahara, Frederick A. Boop, Sid Croul, Paul Kongkham, David W. Ellison, Ronald L. Hamilton, Timothy E. Van Meter, Michael D. Taylor, Young Shin Ra, Carlos Gilberto Carlotti, Adrian M. Dubuc, Stephen C. Mack, Karen Zilberberg, Stephen W. Scherer, Darrell D. Bigner, Jessica McLeod, Boleslaw Lach, James T. Rutka, Lars Feuk, Ian F. Pollack, John Peacock, Richard J. Gilbertson, Wiesia Grajkowska, J. Sunil Rao, Charles G. Eberhart, Xiaochong Wu, Richard Grundy, Yancey Gillespie
We used high-resolution SNP genotyping to identify regions of genomic gain and loss in the genomes of 212 medulloblastomas, malignant pediatric brain tumors. We found focal amplifications of 15 known oncogenes and focal deletions of 20 known tumor su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81c8e5ff321b4f156e7baca6f9c7de60
https://europepmc.org/articles/PMC4454371/
https://europepmc.org/articles/PMC4454371/