Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Darrell Belke"'
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) is a human paracaspase protein with proteolytic activity via its caspase-like domain. The pharmacological inhibition of MALT1 by MI-2, a specific chemical inhibitor,
Externí odkaz:
https://doaj.org/article/07dbb6bad4024d5aa399a2ef7d8a6af9
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Neointima lesion and atherosclerosis are proliferative vascular diseases associated with deregulated proliferation of vascular smooth muscle cells (SMCs). CFI-400945 is a novel, highly effective anticancer drug that inhibits polo-like kinase
Externí odkaz:
https://doaj.org/article/f98653eed3db4c748f214c1b257303cf
Autor:
Karina P. Gomes, Anshul S. Jadli, Luiz G. N. de Almeida, Noura N. Ballasy, Pariya Edalat, Ruchita Shandilya, Daniel Young, Darrell Belke, Jane Shearer, Antoine Dufour, Vaibhav B. Patel
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Diabetic cardiomyopathy (DbCM) occurs independently of cardiovascular diseases or hypertension, leading to heart failure and increased risk for death in diabetic patients. To investigate the molecular mechanisms involved in DbCM, we performed a quant
Externí odkaz:
https://doaj.org/article/472d9b6d24804a8981b506b6e063e7ef
Autor:
Anshul S. Jadli, Noura N. Ballasy, Karina P. Gomes, Cameron D. A. Mackay, Megan Meechem, Tishani Methsala Wijesuriya, Darrell Belke, Jennifer Thompson, Paul W. M. Fedak, Vaibhav B. Patel
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15566 (2022)
Thoracic aortic aneurysm (TAA) involves extracellular matrix (ECM) remodeling of the aortic wall, leading to reduced biomechanical support with risk of aortic dissection and rupture. Activation of the renin-angiotensin system, and resultant angiotens
Externí odkaz:
https://doaj.org/article/159744d741564660a1a0e8b1f099faaf
Autor:
Vishnu, Vasanthan, Hanjoo B, Shim, Guoqi, Teng, Darrell, Belke, Daniyil, Svystonyuk, Justin F, Deniset, Paul W M, Fedak
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 165:e122-e140
After myocardial infarction, we previously showed that epicardial implantation of porcine small intestinal submucosal extracellular matrix (SIS-ECM) improves postinfarct cardiac function through fibroblast-mediated angiogenic and antifibrotic pathway
Publikováno v:
Physiology. 38
Atherosclerosis is a major risk factor for cardiovascular disease and is induced by hyperlipidemia and endothelial dysfunction (ED), leading to fatty plaque formation and impaired vascular function. Pharmacological activation of endothelial Ca2+-acti
Autor:
Vishnu Vasanthan, Ali Fatehi Hassanabad, Darrell Belke, Guoqi Teng, Carmina Albertine Isidoro, Devjyoti Dutta, Jeannine Turnbull, Justin F. Deniset, Paul W.M. Fedak
Publikováno v:
JACC: Basic to Translational Science.
Autor:
Jinhong Wei, Wenting Guo, Ruiwu Wang, John Paul Estillore, Darrell Belke, Yong-Xiang Chen, Alexander Vallmitjana, Raul Benitez, Leif Hove-Madsen, S.R. Wayne Chen
Publikováno v:
Circulation Research. 132
Background: PKA (protein kinase A)–mediated phosphorylation of cardiac RyR2 (ryanodine receptor 2) has been extensively studied for decades, but the physiological significance of PKA phosphorylation of RyR2 remains poorly understood. Recent determi
Autor:
Jinhong, Wei, Wenting, Guo, Ruiwu, Wang, John, Paul Estillore, Darrell, Belke, Yong-Xiang, Chen, Alexander, Vallmitjana, Raul, Benitez, Leif, Hove-Madsen, S R Wayne, Chen
Publikováno v:
Circulation research.
PKA (protein kinase A)-mediated phosphorylation of cardiac RyR2 (ryanodine receptor 2) has been extensively studied for decades, but the physiological significance of PKA phosphorylation of RyR2 remains poorly understood. Recent determination of high
Autor:
Vishnu Vasanthan, darrell belke, Guoqi Teng, Ali Fatehi Hassanabad, Jameson Dundas, Jeannine Turnbull, Justin Deniset, Paul W Fedak
Publikováno v:
Circulation. 144
Introduction: Injection of micronized biomaterials into the pericardial space leverages bioinductive properties to enhance post-infarct cardiac repair. This less invasive, potentially bedside, approach enables early intervention. Micronized porcine s