Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Darran O'Connor"'
Autor:
Leonie S. Young, Arnold D. Hill, Andrew H. Sims, Philip J. O'Halloran, Darran O'Connor, Sudipto Das, Lance Hudson, Siobhan P. Purcell, Sinéad Cocchiglia, Nicola Cosgrove, Alacoque L. Browne, Ailis Fagan, Sara Charmsaz, Damir Varešlija, Elspeth Ward
Detailed description of the materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df0522f7f4bd6a5bf849ecdcf6ccc95
https://doi.org/10.1158/1078-0432.22465116
https://doi.org/10.1158/1078-0432.22465116
Autor:
Leonie S. Young, Arnold D. Hill, Andrew H. Sims, Philip J. O'Halloran, Darran O'Connor, Sudipto Das, Lance Hudson, Siobhan P. Purcell, Sinéad Cocchiglia, Nicola Cosgrove, Alacoque L. Browne, Ailis Fagan, Sara Charmsaz, Damir Varešlija, Elspeth Ward
Figure S1. SRC-1 dependent transcriptome in endocrine resistant LY2 cells. Figure S2. Pathways enriched in SRC-1 repressed gene set. Figure S3. Repression gene set is directly regulated and suppressed by SRC-1. Figure S4. SRC-1 mediates endocrine tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4789c767abd84633d87868dfd06d5b46
https://doi.org/10.1158/1078-0432.22465119
https://doi.org/10.1158/1078-0432.22465119
Autor:
Leonie S. Young, Arnold D. Hill, Andrew H. Sims, Philip J. O'Halloran, Darran O'Connor, Sudipto Das, Lance Hudson, Siobhan P. Purcell, Sinéad Cocchiglia, Nicola Cosgrove, Alacoque L. Browne, Ailis Fagan, Sara Charmsaz, Damir Varešlija, Elspeth Ward
Purpose: Despite the clinical utility of endocrine therapies for estrogen receptor–positive (ER) breast cancer, up to 40% of patients eventually develop resistance, leading to disease progression. The molecular determinants that drive this adaptati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b399b5f9789098af9755b94b86ab5fc
https://doi.org/10.1158/1078-0432.c.6525930.v1
https://doi.org/10.1158/1078-0432.c.6525930.v1
Autor:
Leonie S. Young, Arnold D. Hill, Andrew H. Sims, Philip J. O'Halloran, Darran O'Connor, Sudipto Das, Lance Hudson, Siobhan P. Purcell, Sinéad Cocchiglia, Nicola Cosgrove, Alacoque L. Browne, Ailis Fagan, Sara Charmsaz, Damir Varešlija, Elspeth Ward
Table S1: 736 genes downregulated in LY2 shNT (Ensemble ID)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a00c682bcdf382437de6f67ca9da3624
https://doi.org/10.1158/1078-0432.22465110
https://doi.org/10.1158/1078-0432.22465110
Autor:
Leonie S. Young, Arnold D. Hill, Andrew H. Sims, Philip J. O'Halloran, Darran O'Connor, Sudipto Das, Lance Hudson, Siobhan P. Purcell, Sinéad Cocchiglia, Nicola Cosgrove, Alacoque L. Browne, Ailis Fagan, Sara Charmsaz, Damir Varešlija, Elspeth Ward
Table S2: 251 genes within 5kb of SRC-1 peak upstream of the TSS (Ensembl ID)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282f88e692b13cb637f5850356ff4424
https://doi.org/10.1158/1078-0432.22465113.v1
https://doi.org/10.1158/1078-0432.22465113.v1
Autor:
Elspeth Ward, Anna Blümel, Emer Conroy, Grainne Cremin, Binbin Gao, William Gallagher, Idalia Cruz, Leena Hilakivi-Clarke, George Sflomos, Cathrin Brisken, Darran O'Connor
Publikováno v:
Cancer Research. 82:PD14-07
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer accounting for approximately 10-15% of all breast tumours. ILC is characterized by inactivation of E-Cadherin and cancer cells that invade the stroma in a "single-file"
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c933153e9ec05b7740edd72d94cea9da
https://doi.org/10.1158/1538-7445.sabcs21-pd14-07
https://doi.org/10.1158/1538-7445.sabcs21-pd14-07
Autor:
Zak Kinsella, Anna Blümel, Mairi Lucas, Andreas Lindner, Claudia A. Gonzalez, Arman Rahman, Joanna Fay, Tony O'Grady, Verena Murphy, John Crown, Cathy Kelly, William Gallagher, Darran O'Connor
Publikováno v:
Cancer Research. 83:5787-5787
The frequency of lymphocytes infiltrating tumors is a known prognostic in estrogen receptor (ER) negative cancers. ER+ disease is putatively believed to be immune cold, however, there exists a subset of ER+ tumors with high immune infiltrate and with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9907e6ce7ffa8447fcc3da5d587c0ba
https://doi.org/10.1158/1538-7445.am2023-5787
https://doi.org/10.1158/1538-7445.am2023-5787
Autor:
Mairi Lucas, Zak Kinsella, Claudia Aura Gonzalez, Camille Hurley, Anna Blümel, Joanna Fay, Anthony O'Grady, Verena Murphy, Chowdhury Arif Jahangir, Caoimbhe Burke, Arman Rahman, John Crown, Catherine Margaret Kelly, William M. Gallagher, Darran O'Connor
Publikováno v:
Journal of Clinical Oncology. 40:e12555-e12555
e12555 Background: Tumour infiltrating lymphocytes (TILs), have been associated in higher responses to treatment and are thought to be a prognostic marker in a number of cancer types. The role of TILs in breast cancer varies depending on the molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0b9986889e25fba96621b54f5d3117a
https://doi.org/10.1200/jco.2022.40.16_suppl.e12555
https://doi.org/10.1200/jco.2022.40.16_suppl.e12555
Autor:
Camille Hurley, Laetitia Lacroix, Katherine Sheehan, Mairi Lucas, Rachel Buckley, Anna Blümel, Sinead Toomey, Bryan T. Hennessy, John Crown, Catherine Sautes-Fridman, Darran O'Connor
Publikováno v:
Journal of Clinical Oncology. 40:e15041-e15041
e15041 Background: The treatment of HER2+ breast cancer (BC) has improved substantially with the use of targeted therapies, and patients achieving pathological complete response (pCR) following neoadjuvant therapy have significantly improved disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7eed0c602119aeef65cd5c3788e1f13d
https://doi.org/10.1200/jco.2022.40.16_suppl.e15041
https://doi.org/10.1200/jco.2022.40.16_suppl.e15041
Autor:
Martijn Cordes, Hedde D Biesma, Nicole Ct Grieken, E. Kay, Annette T. Byrne, Johannes Betge, Fotios Loupakis, Bozena Fender, Diether Lambrechts, Verena Murphy, Darran O'Connor, Maarten Neerincx, Dominiek Smeets, Gerrit A. Meijer, Paul P. Eijk, Miriam Koopman, Anna Barat, Rut Klinger, Sudipto Das, Bauke Ylstra, Erik van Dijk, Bryan T Hennessey, Timo Gaiser, Deborah McNamara, Orna Bacon, Jochen Prehn, Cornelis J A Punt, William M. Gallagher, Matthias P. Ebert, Henk M.W. Verheul
Publikováno v:
van Dijk, E, Biesma, H D, Cordes, M, Smeets, D, Neerincx, M, Das, S, Eijk, P P, Murphy, V, Barat, A, Bacon, O, Prehn, J H M, Betge, J, Gaiser, T, Fender, B, Meijer, G A, McNamara, D A, Klinger, R, Koopman, M, Ebert, M P A, Kay, E W, Hennessey, B T, Verheul, H M W, Gallagher, W M, O'Connor, D P, Punt, C J A, Loupakis, F, Lambrechts, D, Byrne, A T, van Grieken, N C T & Ylstra, B 2018, ' Loss of Chromosome 18q11.2-q12.1 Is Predictive for Survival in Patients With Metastatic Colorectal Cancer Treated With Bevacizumab ', Journal of Clinical Oncology, vol. 36, no. 20, 36(20), pp. 2052-2060 . https://doi.org/10.1200/JCO.2017.77.1782
Journal of clinical oncology, 36(20), 2052-2060. American Society of Clinical Oncology
Journal of Clinical Oncology, 36(20), 2052
Journal of Clinical Oncology, 36(20):36(20), 2052-2060. American Society of Clinical Oncology
Journal of Clinical Oncology, 36(20), 2052. American Society of Clinical Oncology
Journal of clinical oncology, 36(20), 2052-2060. American Society of Clinical Oncology
Journal of Clinical Oncology, 36(20), 2052
Journal of Clinical Oncology, 36(20):36(20), 2052-2060. American Society of Clinical Oncology
Journal of Clinical Oncology, 36(20), 2052. American Society of Clinical Oncology
Purpose Patients with metastatic colorectal cancer (mCRC) have limited benefit from the addition of bevacizumab to standard chemotherapy. However, a subset probably benefits substantially, highlighting an unmet clinical need for a biomarker of respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ba7146d6f335343bc2243b7fc344f5
https://research.vumc.nl/en/publications/127c0557-1b3d-4026-9bc5-14ad9e6c3801
https://research.vumc.nl/en/publications/127c0557-1b3d-4026-9bc5-14ad9e6c3801