Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Darpan Saraswat"'
Autor:
Darpan Saraswat, Hani J. Shayya, Jessie J. Polanco, Ajai Tripathi, R. Ross Welliver, Suyog U. Pol, Richard A. Seidman, Jacqueline E. Broome, Melanie A. O’Bara, Toin H. van Kuppervelt, Joanna J. Phillips, Ranjan Dutta, Fraser J. Sim
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Demyelination results in impairments in oligodendrocyte progenitor cell recruitment. Here the authors identify sulfatase 1/2 as a potential modulator of myelination by modulating the microenvironment around oligodendrocyte progenitor cells.
Externí odkaz:
https://doaj.org/article/8405f74419104281af9993328f364b19
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Candida albicans is an opportunistic fungal pathogen colonizing the oral cavity. C. albicans secreted aspartic protease Sap6 is important for virulence during oral candidiasis since it degrades host tissues to release nutrients and essential
Externí odkaz:
https://doaj.org/article/15ddcf2dabd446da987100c3ae3d6c49
Autor:
Jing Wang, Darpan Saraswat, Anjali K. Sinha, Jessie Polanco, Karen Dietz, Melanie A. O’Bara, Suyog U. Pol, Hani J. Shayya, Fraser J. Sim
Publikováno v:
Cell Reports, Vol 25, Iss 12, Pp 3435-3450.e6 (2018)
Summary: Human oligodendrocyte progenitor cells (hOPCs) persist into adulthood as an abundant precursor population capable of division and differentiation. The transcriptional mechanisms that regulate hOPC homeostasis remain poorly defined. Herein, w
Externí odkaz:
https://doaj.org/article/d1aa823735b24a81918352846063fe6d
Autor:
Sumant Puri, Justin Friedman, Darpan Saraswat, Rohitashw Kumar, Rui Li, Donna Ruszaj, Mira Edgerton
Publikováno v:
Pathogens, Vol 4, Iss 4, Pp 752-763 (2015)
Salivary Histatin 5 (Hst 5) is an antimicrobial peptide that exhibits potent antifungal activity towards Candida albicans, the causative agent of oral candidiasis. However, it exhibits limited activity in vivo, largely due to inactivation by salivary
Externí odkaz:
https://doaj.org/article/66a2ce45a851475eb7d19488f1c8291d
Autor:
James J. M. Cooper, Jessie J. Polanco, Darpan Saraswat, Jennifer J. Peirick, Anna Seidl, Yi Li, Dan Ma, Fraser J. Sim
Publikováno v:
Glia. 71:1018-1035
The failure of remyelination in the human CNS contributes to axonal injury and disease progression in multiple sclerosis (MS). In contrast to regions of chronic demyelination in the human brain, remyelination in murine models is preceded by abundant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01808cb9122a4a260435802c9724303
https://doi.org/10.1002/glia.24324
https://doi.org/10.1002/glia.24324
Autor:
Jacqueline E. Broome, Ajai Tripathi, Fraser J. Sim, Darpan Saraswat, Suyog Pol, Ranjan Dutta, R. Ross Welliver, Melanie A. O'Bara, Hani J. Shayya, Jessie J. Polanco, Richard A. Seidman, Joanna J. Phillips, Toin H. van Kuppervelt
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Chronic demyelination in the human CNS is characterized by an inhibitory microenvironment that impairs recruitment and differentiation of oligodendrocyte progenitor cells (OPCs) leading to failed remyelination and axonal atrophy. By network-based tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd869a845f4787f2e1d1c13a69c255d
https://doi.org/10.1038/s41467-021-22263-4
https://doi.org/10.1038/s41467-021-22263-4
Publikováno v:
J Am Soc Mass Spectrom
Destruction of myelin, or demyelination, is a characteristic of traumatic spinal cord injury and pathognomonic for primary demyelinating pathologies such as multiple sclerosis (MS). The regenerative process known as remyelination, which can occur fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037d6130da4fae7edfbbeeb89561d3aa
https://pubmed.ncbi.nlm.nih.gov/32926612
https://pubmed.ncbi.nlm.nih.gov/32926612
Autor:
Darpan Saraswat, Hani J. Shayya, Jessie J. Polanco, Ajai Tripathi, R. Ross Welliver, Suyog U. Pol, Richard A. Seidman, Jacqueline E. Broome, Melanie A. O’Bara, Toin H. van Kuppervelt, Joanna J. Phillips, Ranjan Dutta, Fraser J. Sim
Chronic demyelination in the human CNS is characterized by an inhibitory microenvironment that impairs recruitment and differentiation of oligodendrocyte progenitor cells (OPCs) leading to failed remyelination and axonal atrophy. By network-based tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce361fd858496b65b53a4a6dfad2c9de
Publikováno v:
Molecular Microbiology. 100:425-441
Temperature is a potent inducer of fungal dimorphism. Multiple signalling pathways control the response to growth at high temperature, but the sensors that regulate these pathways are poorly defined. We show here that the signalling mucin Msb2 is a g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43af3275d432e5b9dfa504bf3106d5d9
https://doi.org/10.1111/mmi.13326
https://doi.org/10.1111/mmi.13326
Publikováno v:
Infection and Immunity. 83:2614-2626
Candida albicans , a commensal fungus of the oral microbiome, causes oral candidiasis in humans with localized or systemic immune deficiencies. Secreted aspartic proteinases (Saps) are a family of 10 related proteases and are virulence factors due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef58d7466fa94a9315f50026eb37539
https://doi.org/10.1128/iai.00282-15
https://doi.org/10.1128/iai.00282-15