Výsledky vyhledávání - "Darol E. Dodd"

Akademický článek

Subchronic Hepatotoxicity Evaluation of 2,3,4,6-Tetrachlorophenol in Sprague Dawley Rats

Autor: Darol E. Dodd, Linda J. Pluta, Mark A. Sochaski, Deborah A. Banas, Russell S. Thomas

Publikováno v: Journal of Toxicology, Vol 2012 (2012)

Male Sprague Dawley rats were exposed to 2,3,4,6-tetrachlorophenol (TCP) for 5 days, 2 weeks, 4 weeks, or 13 weeks. TCP was administered by gavage at doses of 0, 10, 25, 50, 100, or 200 mg/kg/day. Endpoints evaluated included clinical observations, b

Externí odkaz: https://doaj.org/article/a0210aaad58c4aca94b2c1ee8dc2ebd5

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Toxicity and occupational exposure assessment for hydroprocessed esters and fatty acids (HEFA) alternative jet fuels

Autor: James E. Reboulet, Teresa R. Sterner, R. Arden James, Richard C. Striebich, Darol E. Dodd, David R. Mattie, Brian A. Wong, Karen L. Mumy

Publikováno v: Journal of toxicology and environmental health. Part A. 83(5)

The U.S. Air Force (USAF) has pursued development of alternative fuels to augment or replace petroleum-based jet fuels. Hydroprocessed esters and fatty acids (HEFA) renewable jet fuel is certified for use in commercial and USAF aircraft. HEFA feedsto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7d14e7c9c7182f3de36ac2ee2c74a5
https://pubmed.ncbi.nlm.nih.gov/32195630

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Toxicity and occupational exposure assessment for Fischer-Tropsch synthetic paraffinic kerosene

Autor: Katherine Kurtz, Brian A. Wong, Darol E. Dodd, John P Hinz, Gunda Reddy, Dean J. Wagner, James T. Edwards, Wayne C. Daughtrey, Errol Zeiger, Teresa R Sterner, David R. Mattie, David Steup

Publikováno v: Journal of Toxicology and Environmental Health, Part A. 81:774-791

Fischer-Tropsch (FT) Synthetic Paraffinic Kerosene (SPK) jet fuel is a synthetic organic mixture intended to augment petroleum-derived JP-8 jet fuel use by the U.S. armed forces. The FT SPK testing program goal was to develop a comparative toxicity d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a458f7664c1455af44ada00f8f8597f
https://doi.org/10.1080/15287394.2018.1490675

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Autor: Michael B. Black, Patrick D. McMullen, Darol E. Dodd, James S. Bus, Salil N. Pendse, Robbie Waites, Melvin E. Andersen, George Cruzan, Satinder S. Sarang, Marcy I. Banton, Debra B. Layko

Publikováno v: Regulatory Toxicology and Pharmacology. 96:153-166

Both CD-1 and C57BL/6 wildtype (C57BL/6-WT) mice show equivalent short-term lung toxicity from exposures to styrene, while long-term tumor responses are greater in CD-1 mice. We analyzed lung gene expression from styrene exposures lasting from 1-day

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13bc5817fdeefc401182930bce8587b4
https://doi.org/10.1016/j.yrtph.2018.05.011

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Combining transcriptomics and PBPK modeling indicates a primary role of hypoxia and altered circadian signaling in dichloromethane carcinogenicity in mouse lung and liver

Autor: Lynn H. Pottenger, Daniel C. Kemp, Salil N. Pendse, James S. Bus, Darol E. Dodd, Harvey J. Clewell, Melvin E. Andersen, Michael B. Black, Jerry L. Campbell, Patrick D. McMullen

Publikováno v: Toxicology and Applied Pharmacology. 332:149-158

Dichloromethane (DCM) is a lung and liver carcinogen in mice at inhalation exposures ≥ 2000 ppm. The modes of action (MOA) of these responses have been attributed to formation of genotoxic, reactive metabolite(s). Here, we examined gene expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e291747c7c5ac7a23ced5e18aa254ad
https://doi.org/10.1016/j.taap.2017.04.002

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Time- and concentration-dependent genomic responses of the rat airway to inhaled nickel sulfate

Autor: Darol E. Dodd, Harvey J. Clewell, Adriana R. Oller, Alina Efremenko, Jerry L. Campbell

Publikováno v: Environmental and Molecular Mutagenesis. 58:607-618

While insoluble nickel subsulfide (Ni3 S2 ) was carcinogenic in the lung in a 2-year rat bioassay, soluble nickel sulfate hexahydrate (NiSO4* 6H2 O) was not. To investigate whether differences in the cellular responses to these two nickel compounds c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f2c615aceedcb922f5d740b35e2a513
https://doi.org/10.1002/em.22139

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Editor’s Highlight: Complete Attenuation of Mouse Lung Cell Proliferation and Tumorigenicity in CYP2F2 Knockout and CYP2F1 Humanized Mice Exposed to Inhaled Styrene for up to 2 Years Supports a Lack of Human Relevance

Autor: Marcy I. Banton, Robbie Waites, Melvin E. Andersen, Satinder S. Sarang, Debra B. Layko, James S. Bus, George Cruzan, Darol E. Dodd, James T. Raymond

Publikováno v: Toxicological Sciences

Styrene is a mouse-specific lung carcinogen, and short-term mode of action studies have demonstrated that cytotoxicity and/or cell proliferation, and genomic changes are dependent on CYP2F2 metabolism. The current study examined histopathology, cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e176c65f371e5fafad79a9ddf6932b
http://europepmc.org/articles/PMC5837194

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Using gene expression profiling to evaluate cellular responses in mouse lungs exposed to V2O5 and a group of other mouse lung tumorigens and non-tumorigens

Autor: Salil N. Pendse, Melvin E. Andersen, Michael B. Black, Patrick D. McMullen, B. Bhaskar Gollapudi, Darol E. Dodd, Judith A. MacGregor

Publikováno v: Regulatory Toxicology and Pharmacology. 73:339-347

Many compounds test positive for lung tumors in two-year NTP carcinogenicity bioassays in B6C3F1 mice. V2O5 was identified as a lung carcinogen in this assay, leading to its IARC (International Agency for Research on Cancer) classification as group 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90668a7340ea840da60d51ec83d27f1e
https://doi.org/10.1016/j.yrtph.2015.07.017

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Assessing molecular initiating events (MIEs), key events (KEs) and modulating factors (MFs) for styrene responses in mouse lungs using whole genome gene expression profiling following 1-day and multi-week exposures

Autor: Melvin E. Andersen, Marcy I. Banton, Salil N. Pendse, George Cruzan, Patrick D. McMullen, Michael B. Black, Darol E. Dodd, Robbie Waites, Satinder S. Sarang, James S. Bus

Publikováno v: Toxicology and applied pharmacology. 335

Styrene increased lung tumors in mice at chronic inhalation exposures of 20ppm and greater. MIEs, KEs and MFs were examined using gene expression in three strains of male mice (the parental C57BL/6 strain, a CYP2F2(-/-) knock out and a CYP2F2(-/-) tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e1800c56d3a563e89dff1fcbd441a4
https://pubmed.ncbi.nlm.nih.gov/28951217

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