Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Darlene Chen"'
Autor:
Anastasia Hyrina, Christopher Jones, Darlene Chen, Scott Clarkson, Nadire Cochran, Paul Feucht, Gregory Hoffman, Alicia Lindeman, Carsten Russ, Frederic Sigoillot, Tiffany Tsang, Kyoko Uehara, Lili Xie, Don Ganem, Meghan Holdorf
Publikováno v:
Cell Reports, Vol 29, Iss 10, Pp 2970-2978.e6 (2019)
Summary: A hallmark of chronic hepatitis B (CHB) virus infection is the presence of high circulating levels of non-infectious small lipid HBV surface antigen (HBsAg) vesicles. Although rare, sustained HBsAg loss is the idealized endpoint of any CHB t
Externí odkaz:
https://doaj.org/article/1de14fd71bb445e89c5fdea311bfc65e
Autor:
Meghan Holdorf, Nadire Cochran, Lili Xie, Paul Feucht, Scott Clarkson, Kyoko Uehara, Gregory R. Hoffman, Darlene Chen, Don Ganem, Frederic Sigoillot, Carsten Russ, Anastasia Hyrina, Alicia Lindeman, Christopher T. Jones
GRAPHICAL ABSTRACTSUMMARYA hallmark of chronic hepatitis B virus (CHB) infection is the presence of high circulating levels of non-infectious small lipid HBV surface antigen (HBsAg) vesicles. Although rare, sustained HBsAg loss is the idealized endpo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260bc9cfe9475b4cb2496f1e7d32b1ec
Autor:
Frederic Sigoillot, Lili Xie, Don Ganem, Kyoko Uehara, Scott Clarkson, Carsten Russ, Nadire Cochran, Tiffany Tsang, Gregory R. Hoffman, Darlene Chen, Meghan Holdorf, Paul Feucht, Anastasia Hyrina, Christopher T. Jones, Alicia Lindeman
Publikováno v:
Cell Reports, Vol 29, Iss 10, Pp 2970-2978.e6 (2019)
Summary: A hallmark of chronic hepatitis B (CHB) virus infection is the presence of high circulating levels of non-infectious small lipid HBV surface antigen (HBsAg) vesicles. Although rare, sustained HBsAg loss is the idealized endpoint of any CHB t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437c578ad7f817c270632ea67c9e190a
https://pubmed.ncbi.nlm.nih.gov/31801065
https://pubmed.ncbi.nlm.nih.gov/31801065
Publikováno v:
Journal of Biological Chemistry. 287:36488-36498
The first step in V(D)J recombination is the formation of specific DNA double-strand breaks (DSBs) by the RAG1 and RAG2 proteins, which form the RAG recombinase. DSBs activate a complex network of proteins termed the DNA damage response (DDR). A key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301c411dc37750a4dd6afdd0ac537fb2
https://doi.org/10.1074/jbc.m112.402487
https://doi.org/10.1074/jbc.m112.402487
Autor:
Thomas Marbury, Steven J. Kovacs, Jay Parthiban Lakshman, Kelly A. Wong, Marjorie Ison, Prakash Raman, Kristina Dabovic, Ursula Bodendorf, Kathryn Rene Bracken, Darlene Chen, Bin Li, Weidong Zhong, Richard Colvin, Eric Lawitz, Sanjeev Thohan, Erica Canino, Avantika Barve, Mohamed Bidair, Baldur Magnusson, Catherine L. Jones, Tycho Heimbach, Rachael Steiner-Swiat, Christopher T. Jones, David T. Barkan
Publikováno v:
Clinical Therapeutics. 40:1567-1581.e4
Purpose Infection with hepatitis C virus is the leading cause of infectious disease mortality in the United States. BZF961 is a novel small molecule inhibitor of the hepatitis C virus NS3-4A protease. Here we present the results of a randomized, doub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfdfa07688ce19598b6389ed797456d8
https://doi.org/10.1016/j.clinthera.2018.07.019
https://doi.org/10.1016/j.clinthera.2018.07.019
Publikováno v:
Journal of Biological Chemistry. 279:53379-53386
In the human genome the apolipoprotein B mRNA-editing enzyme catalytic polypeptide (APOBEC)3 gene has expanded into a tandem array of genes termed APOBEC3A-G. Two members of this family, APOBEC3G and APOBEC3F, have been found to have potent activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d5e71f00cb4f9165060684777a2670
https://doi.org/10.1074/jbc.m408802200
https://doi.org/10.1074/jbc.m408802200
Publikováno v:
Proceedings of the National Academy of Sciences. 101:3927-3932
The virion infectivity factor (Vif) accessory protein of HIV-1 forms a complex with the cellular cytidine deaminase APOBEC3G (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G) to block its antiviral activity. The antiviral property
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b50104eb9bce39d583393f79781715
https://doi.org/10.1073/pnas.0307132101
https://doi.org/10.1073/pnas.0307132101
Autor:
Francisco Navarro, Darlene Chen, Brooke Bollman, Bärbel Schröfelbauer, Nathaniel R. Landau, Renate König, Carsten Münk, Roberto Mariani, Henrietta Nymark-McMahon
Publikováno v:
Cell. 114(1)
The HIV-1 accessory protein Vif (virion infectivity factor) is required for the production of infectious virions by CD4 + lymphocytes. Vif facilitates particle infectivity by blocking the inhibitory activity of APOBEC3G (CEM15), a virion-encapsidated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea8533e8c41d2395c139c8a620af7ae0
https://pubmed.ncbi.nlm.nih.gov/12859895
https://pubmed.ncbi.nlm.nih.gov/12859895
Autor:
Delores Mo, Ricardo A. Maselli, Constance M. Bowe, Grace Fenton, Darlene Chen, Robert L. Wollmann
Publikováno v:
Musclenerve. 27(2)
The myasthenic syndrome due to abnormal acetylcholine resynthesis is characterized by early onset, recessive inheritance, and recurrent episodes of potentially fatal apnea. Mutations in the gene encoding choline acetyltransferase (CHAT) have been fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30e1399fe88b26606b96d475ea47e5d
https://pubmed.ncbi.nlm.nih.gov/12548525
https://pubmed.ncbi.nlm.nih.gov/12548525
Autor:
Claudio Avila, Bin Li, June Ke, Darlene Chen, Brigitte Weidmann, Nikolai V. Naoumov, J. Yu, Yanhua Tang, Kelly A. Wong, Christopher T. Jones, Jean-Michel Pawlotsky, W. Bao, Kai Lin
Publikováno v:
Gastroenterology. 144:S-977
BACKGROUND: VITAL-1 study assessed safety, tolerability and antiviral activity of the cyclophilin inhibitor alisporivir (ALV) as monotherapy or combination with ribavirin (RBV) compared to IFN/RBV and ALV/IFN in treatment-naive GT2/3 HCV patients. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b443302663b0891a2110017931957233
https://doi.org/10.1016/s0016-5085(13)63628-8
https://doi.org/10.1016/s0016-5085(13)63628-8