Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Darlene A. Burke"'
Autor:
Zimple Kurlawala, Joseph D. McMillan, Richa A. Singhal, Johnny Morehouse, Darlene A. Burke, Sophia M. Sears, Eleonora Duregon, Levi J. Beverly, Leah J. Siskind, Robert P. Friedland
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract The gut microbiome is a potential non-genetic contributing factor for Amyotrophic Lateral Sclerosis. Differences in gut microbial communities have been detected between ALS subjects and healthy controls, including an increase in Escherichia
Externí odkaz:
https://doaj.org/article/bf12b87e9c054a8b89f8e90cbfff0845
Publikováno v:
Neurotrauma Reports, Vol 4, Iss 1, Pp 71-81 (2023)
It is well established that both positive and negative housing conditions of laboratory animals can affect behavioral, biochemical, and physiological responses. Housing enhancements have been shown to have beneficial effects on locomotor outcomes in
Externí odkaz:
https://doaj.org/article/63cf2249cbca40c9b0b0692c57630fac
Autor:
Ben C. Orem, Johnny R. Morehouse, Spencer Ames, Darlene A. Burke, David S.K. Magnuson, David P. Stirling
Publikováno v:
Neurotrauma Reports, Vol 3, Iss 1, Pp 433-446 (2022)
Neuronal ryanodine receptors (RyR) release calcium from internal stores and play a key role in synaptic plasticity, learning, and memory. Dysregulation of RyR function contributes to neurodegeneration and negatively impacts neurological recovery afte
Externí odkaz:
https://doaj.org/article/d2ba62b72e794ac49db69c31c3781f07
Autor:
Amanda M. Pocratsky, Darlene A. Burke, Johnny R. Morehouse, Jason E. Beare, Amberly S. Riegler, Pantelis Tsoulfas, Gregory J. R. States, Scott R. Whittemore, David S. K. Magnuson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Intra- and interlimb coordination during locomotion is governed by hierarchically organized lumbar spinal networks. Here, the authors show that reversible silencing of spinal L2–L5 interneurons specifically disrupts hindlimb alternation leading to
Externí odkaz:
https://doaj.org/article/61c12fdd45c24223be75489c98ecb5e8
Autor:
Courtney T Shepard, Amanda M Pocratsky, Brandon L Brown, Morgan A Van Rijswijck, Rachel M Zalla, Darlene A Burke, Johnny R Morehouse, Amberley S Riegler, Scott R Whittemore, David SK Magnuson
Publikováno v:
eLife, Vol 10 (2021)
Long ascending propriospinal neurons (LAPNs) are a subpopulation of spinal cord interneurons that directly connect the lumbar and cervical enlargements. Previously we showed, in uninjured animals, that conditionally silencing LAPNs disrupted left-rig
Externí odkaz:
https://doaj.org/article/76d9111e10d94c34bf93f809c60aae3d
Publikováno v:
Neurotrauma Reports. 4:71-81
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9857502551c645a59d62aa522cf5cda
https://doi.org/10.1089/neur.2022.0059
https://doi.org/10.1089/neur.2022.0059
Autor:
Amanda M Pocratsky, Courtney T Shepard, Johnny R Morehouse, Darlene A Burke, Amberley S Riegler, Josiah T Hardin, Jason E Beare, Casey Hainline, Gregory JR States, Brandon L Brown, Scott R Whittemore, David SK Magnuson
Publikováno v:
eLife, Vol 9 (2020)
Within the cervical and lumbar spinal enlargements, central pattern generator (CPG) circuitry produces the rhythmic output necessary for limb coordination during locomotion. Long propriospinal neurons that inter-connect these CPGs are thought to secu
Externí odkaz:
https://doaj.org/article/1d2ab2ad153547348c5c71b83cd2cbee
Autor:
Courtney T Shepard, Brandon L Brown, Morgan A Van Rijswijck, Rachel M Zalla, Darlene A Burke, Johnny R Morehouse, Amberley S Riegler, Scott R Whittemore, David SK Magnuson
Spinal locomotor circuitry is comprised of rhythm generating centers, one for each limb, that are interconnected by local and long-distance propriospinal neurons thought to carry temporal information necessary for interlimb coordination and gait cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba211b3ed591ed6eda9823ba7f7a315c
https://doi.org/10.1101/2022.08.30.505848
https://doi.org/10.1101/2022.08.30.505848
Autor:
Sujata Saraswat Ohri, Kariena R. Andres, Darlene A. Burke, Michal Hetman, Scott R. Whittemore
Publikováno v:
J Neurotrauma
One of the difficulties in identifying novel therapeutic strategies to manage central nervous system (CNS) trauma is the need for behavioral assays to assess chronic functional recovery. In vitro assays and/or acute behavioral assessments cannot accu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2795bbc93f6ca20ceba1e7ca32e809
https://doi.org/10.1089/neu.2020.7258
https://doi.org/10.1089/neu.2020.7258
Autor:
Chitra Kumar, Leslie C. Sherwood, Neda Manouchehri, Johnny R. Morehouse, Jay Ethridge, Nicolas K Khattar, Darlene A. Burke, Femke Streijger, Robert W. Reed, David S.K. Magnuson, Maxwell Boakye, Brian K. Kwon, Dena R. Howland
Publikováno v:
J Neurotrauma
Yucatan miniature pigs (YMPs) are similar to humans in spinal cord size as well as physiological and neuroanatomical features, making them a useful model for human spinal cord injury. However, little is known regarding pig gait kinematics, especially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::112e0479cec399e7d13d4efba1d8cd97
https://doi.org/10.1089/neu.2020.7050
https://doi.org/10.1089/neu.2020.7050