Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Darlene A, Burke"'
Autor:
Zimple Kurlawala, Joseph D. McMillan, Richa A. Singhal, Johnny Morehouse, Darlene A. Burke, Sophia M. Sears, Eleonora Duregon, Levi J. Beverly, Leah J. Siskind, Robert P. Friedland
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract The gut microbiome is a potential non-genetic contributing factor for Amyotrophic Lateral Sclerosis. Differences in gut microbial communities have been detected between ALS subjects and healthy controls, including an increase in Escherichia
Externí odkaz:
https://doaj.org/article/bf12b87e9c054a8b89f8e90cbfff0845
Autor:
Courtney T Shepard, Brandon L Brown, Morgan A Van Rijswijck, Rachel M Zalla, Darlene A Burke, Johnny R Morehouse, Amberly S Riegler, Scott R Whittemore, David SK Magnuson
Publikováno v:
eLife, Vol 12 (2023)
Spinal locomotor circuitry is comprised of rhythm generating centers, one for each limb, that are interconnected by local and long-distance propriospinal neurons thought to carry temporal information necessary for interlimb coordination and gait cont
Externí odkaz:
https://doaj.org/article/2fe9eeda317740ffa74b222679cc71bc
Publikováno v:
Neurotrauma Reports, Vol 4, Iss 1, Pp 71-81 (2023)
It is well established that both positive and negative housing conditions of laboratory animals can affect behavioral, biochemical, and physiological responses. Housing enhancements have been shown to have beneficial effects on locomotor outcomes in
Externí odkaz:
https://doaj.org/article/63cf2249cbca40c9b0b0692c57630fac
Autor:
Ben C. Orem, Johnny R. Morehouse, Spencer Ames, Darlene A. Burke, David S.K. Magnuson, David P. Stirling
Publikováno v:
Neurotrauma Reports, Vol 3, Iss 1, Pp 433-446 (2022)
Neuronal ryanodine receptors (RyR) release calcium from internal stores and play a key role in synaptic plasticity, learning, and memory. Dysregulation of RyR function contributes to neurodegeneration and negatively impacts neurological recovery afte
Externí odkaz:
https://doaj.org/article/d2ba62b72e794ac49db69c31c3781f07
Autor:
Courtney T Shepard, Amanda M Pocratsky, Brandon L Brown, Morgan A Van Rijswijck, Rachel M Zalla, Darlene A Burke, Johnny R Morehouse, Amberley S Riegler, Scott R Whittemore, David SK Magnuson
Publikováno v:
eLife, Vol 10 (2021)
Long ascending propriospinal neurons (LAPNs) are a subpopulation of spinal cord interneurons that directly connect the lumbar and cervical enlargements. Previously we showed, in uninjured animals, that conditionally silencing LAPNs disrupted left-rig
Externí odkaz:
https://doaj.org/article/76d9111e10d94c34bf93f809c60aae3d
Autor:
Lukasz P Slomnicki, George Wei, Darlene A Burke, Emily R Hodges, Scott A Myers, Christine D Yarberry, Johnny R Morehouse, Scott R Whittemore, Sujata Saraswat Ohri, Michal Hetman
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0249981 (2021)
The circadian gene expression rhythmicity drives diurnal oscillations of physiological processes that may determine the injury response. While outcomes of various acute injuries are affected by the time of day at which the original insult occurred, s
Externí odkaz:
https://doaj.org/article/f29cd798582847b9bb759213f45b5360
Autor:
Amanda M Pocratsky, Courtney T Shepard, Johnny R Morehouse, Darlene A Burke, Amberley S Riegler, Josiah T Hardin, Jason E Beare, Casey Hainline, Gregory JR States, Brandon L Brown, Scott R Whittemore, David SK Magnuson
Publikováno v:
eLife, Vol 9 (2020)
Within the cervical and lumbar spinal enlargements, central pattern generator (CPG) circuitry produces the rhythmic output necessary for limb coordination during locomotion. Long propriospinal neurons that inter-connect these CPGs are thought to secu
Externí odkaz:
https://doaj.org/article/1d2ab2ad153547348c5c71b83cd2cbee
Autor:
Amanda M. Pocratsky, Darlene A. Burke, Johnny R. Morehouse, Jason E. Beare, Amberly S. Riegler, Pantelis Tsoulfas, Gregory J. R. States, Scott R. Whittemore, David S. K. Magnuson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Intra- and interlimb coordination during locomotion is governed by hierarchically organized lumbar spinal networks. Here, the authors show that reversible silencing of spinal L2–L5 interneurons specifically disrupts hindlimb alternation leading to
Externí odkaz:
https://doaj.org/article/61c12fdd45c24223be75489c98ecb5e8
Autor:
Courtney T Shepard, Brandon L Brown, Morgan A Van Rijswijck, Rachel M Zalla, Darlene A Burke, Johnny R Morehouse, Amberley S Riegler, Scott R Whittemore, David SK Magnuson
Spinal locomotor circuitry is comprised of rhythm generating centers, one for each limb, that are interconnected by local and long-distance propriospinal neurons thought to carry temporal information necessary for interlimb coordination and gait cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba211b3ed591ed6eda9823ba7f7a315c
https://doi.org/10.1101/2022.08.30.505848
https://doi.org/10.1101/2022.08.30.505848
Autor:
Sujata Saraswat Ohri, Kariena R. Andres, Darlene A. Burke, Michal Hetman, Scott R. Whittemore
Publikováno v:
J Neurotrauma
One of the difficulties in identifying novel therapeutic strategies to manage central nervous system (CNS) trauma is the need for behavioral assays to assess chronic functional recovery. In vitro assays and/or acute behavioral assessments cannot accu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2795bbc93f6ca20ceba1e7ca32e809
https://doi.org/10.1089/neu.2020.7258
https://doi.org/10.1089/neu.2020.7258