Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Darko CA"'
Autor:
Wafaa Abumustafa, Darko Castven, Fatemeh Saheb Sharif-Askari, Batoul Abi Zamer, Mawieh Hamad, Jens-Uwe Marquardt, Jibran Sualeh Muhammad
Publikováno v:
Biology, Vol 13, Iss 4, p 216 (2024)
Protein arginine N-methyltransferase 5 (PRMT5) has been identified as a potential therapeutic target for various cancer types. However, its role in regulating the hepatocellular carcinoma (HCC) transcriptome remains poorly understood. In this study,
Externí odkaz:
https://doaj.org/article/7ed6f199d3964bc5b98456735e80f93e
Autor:
Darko Castven, Carolin Czauderna, Diana Becker, Sharon Pereira, Jennifer Schmitt, Arndt Weinmann, Viral Shah, Jovana Hajduk, Friederike Keggenhoff, Harald Binder, Tobias Keck, Stefanie Heilmann‐Heimbach, Marcus A. Wörns, Snorri S. Thorgeirsson, Kai Breuhahn, Peter R. Galle, Jens U. Marquardt
Publikováno v:
Hepatology Communications, Vol 6, Iss 5, Pp 1140-1156 (2022)
Induction of neoangiogenesis is a hallmark feature during disease progression of hepatocellular carcinoma (HCC). Antiangiogenetic compounds represent a mainstay of therapeutic approaches; however, development of chemoresistance is observed in the maj
Externí odkaz:
https://doaj.org/article/cede644f770a4897acbb1b8893fbe1cc
Autor:
Rüdiger Braun, Olha Lapshyna, Jessica Watzelt, Maren Drenckhan, Axel Künstner, Benedikt Färber, Ahmed Ahmed Mohammed Hael, Louisa Bolm, Kim Christin Honselmann, Björn Konukiewitz, Darko Castven, Malte Spielmann, Sivahari Prasad Gorantla, Hauke Busch, Jens-Uwe Marquardt, Tobias Keck, Ulrich Friedrich Wellner, Hendrik Ungefroren
Publikováno v:
Cells, Vol 12, Iss 4, p 587 (2023)
The prognosis of pancreatic ductal adenocarcinoma (PDAC) is exceedingly poor. Although surgical resection is the only curative treatment option, multimodal treatment is of the utmost importance, as only about 20% of tumors are primarily resectable at
Externí odkaz:
https://doaj.org/article/217dd6f9a824404c944446bfa3c6760d
Autor:
Carolin Czauderna, Alicia Poplawski, Colm J. O’Rourke, Darko Castven, Benjamín Pérez-Aguilar, Diana Becker, Stephanie Heilmann-Heimbach, Margarete Odenthal, Wafa Amer, Marcel Schmiel, Uta Drebber, Harald Binder, Dirk A. Ridder, Mario Schindeldecker, Beate K. Straub, Peter R. Galle, Jesper B. Andersen, Snorri S. Thorgeirsson, Young Nyun Park, Jens U. Marquardt
Publikováno v:
JCI Insight, Vol 6, Iss 17 (2021)
Development of primary liver cancer is a multistage process. Detailed understanding of sequential epigenetic alterations is largely missing. Here, we performed Infinium Human Methylation 450k BeadChips and RNA-Seq analyses for genome-wide methylome a
Externí odkaz:
https://doaj.org/article/fdbdddf2a9ee4950b5ed9ce6afdf10af
Autor:
Zeribe Chike Nwosu, Weronika Piorońska, Nadia Battello, Andreas David Zimmer, Bedair Dewidar, Mei Han, Sharon Pereira, Biljana Blagojevic, Darko Castven, Verodia Charlestin, Pavlo Holenya, Julia Lochead, Carolina De La Torre, Norbert Gretz, Peter Sajjakulnukit, Li Zhang, Matthew H. Ward, Jens U. Marquardt, Marina Pasca di Magliano, Costas A. Lyssiotis, Jonathan Sleeman, Stefan Wölfl, Matthias Philip Ebert, Christoph Meyer, Ute Hofmann, Steven Dooley
Publikováno v:
EBioMedicine, Vol 54, Iss , Pp - (2020)
Background: The extracellular signal-regulated kinase (ERK) pathway regulates cell growth, and is hyper-activated and associated with drug resistance in hepatocellular carcinoma (HCC). Metabolic pathways are profoundly dysregulated in HCC. Whether an
Externí odkaz:
https://doaj.org/article/383d5f40c0a84df0afc5bf27b396bda2
Akademický článek
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Akademický článek
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Autor:
Carolin Czauderna, Mayrel Palestino-Dominguez, Darko Castven, Diana Becker, Luis Zanon-Rodriguez, Jovana Hajduk, Friederike L Mahn, Monika Herr, Dennis Strand, Susanne Strand, Stefanie Heilmann-Heimbach, Luis E Gomez-Quiroz, Marcus A Wörns, Peter R Galle, Jens U Marquardt
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0209067 (2018)
Ginkgo biloba (EGb761) is a widely used botanical drug. Several reports indicate that EGb761 confers preventive as well as anti-tumorigenic properties in a variety of tumors, including hepatocellular carcinoma (HCC). We here evaluate functional effec
Externí odkaz:
https://doaj.org/article/0a7318c580844bafa5e06a8adbd9c70b
Publikováno v:
International Journal of Computational Intelligence Systems, Vol 4, Iss 4 (2011)
Grid computing could be the future computing paradigm for enterprise applications, one of its benefits being that it can be used for executing large scale applications. Utility Management Systems execute very large numbers of workflows with very high
Externí odkaz:
https://doaj.org/article/3995c31971d34a639b0596c25b8b2f32
Akademický článek
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