Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Dariusz Stepniak"'
Publikováno v:
The Journal of Immunology. 204:86.53-86.53
Although microglia are the predominant resident macrophages of the central nervous system (CNS), other macrophages can be found in the CNS. As both populations express CD11b, microglia are generally distinguished from peripheral macrophages by lower
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa27e9573c736086cf58675c4db0f740
https://doi.org/10.4049/jimmunol.204.supp.86.53
https://doi.org/10.4049/jimmunol.204.supp.86.53
Publikováno v:
Methods (San Diego, Calif.).
Analysis of RNA expression in mixed cell populations often requires laborious and costly cell sorting. Here we describe a flow cytometric assay that combines antibody staining and in situ hybridization for multi-parametric analysis of single cells. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d4acb2416a9ef92563e181d77731fe
https://pubmed.ncbi.nlm.nih.gov/29277634
https://pubmed.ncbi.nlm.nih.gov/29277634
Autor:
Sarkis K. Mazmanian, Lin Lin, Dariusz Stepniak, Philippe Krebs, Gerhard Wingender, Bo Wei, Mitchell Kronenberg, Sarah McBride, Jonathan Braun
Publikováno v:
Gastroenterology
Background & Aims: Invariant natural killer T (iNKT) cells undergo canonical, Vα14–Jα18 rearrangement of the T-cell receptor (TCR) in mice; this form of the TCR recognizes glycolipids presented by CD1d. iNKT cells mediate many different immune re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edc3fe28ed95b5129bc8125d95af34b2
Autor:
Luppo Edens, Martine Moester, Peter A. van Veelen, Frits Koning, Dariusz Stepniak, Liesbeth Spaenij-Dekking, Arnoud H. de Ru, Cristina Mitea, Renee Baak-Pablo
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 291:G621-G629
Celiac disease is a T cell-driven intolerance to wheat gluten. The gluten-derived T cell epitopes are proline-rich and thereby highly resistant to proteolytic degradation within the gastrointestinal tract. Oral supplementation with prolyl oligopeptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac93c52d7e3e43ba1a445adaf8fbc6b
https://doi.org/10.1152/ajpgi.00034.2006
https://doi.org/10.1152/ajpgi.00034.2006
Autor:
Frits Koning, Dariusz Stepniak
Publikováno v:
Human Immunology. 67:460-468
Celiac disease (CD) patients are intolerant to gluten, proteins in wheat, and related cereals. Virtually all patients are human leukocyte antigen (HLA)-DQ2 or HLA-DQ8 positive and several studies have demonstrated that CD4 T cells specific for (modif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931878f034817c56912f879f5c07600f
https://doi.org/10.1016/j.humimm.2006.03.011
https://doi.org/10.1016/j.humimm.2006.03.011
Autor:
Martin C. Wapenaar, Begoña Diosdado, Cisca Wijmenga, M.L. Mearin, Alienke J. Monsuur, Dariusz Stepniak, Frits Koning
Publikováno v:
Scopus-Elsevier
Coeliac disease (CD) is an enteropathy caused by an immune reaction towards wheat gluten and similar proteins from barley and rye. It was shown that some gluten peptides spontaneously form N-terminal L-pyroglutamate. This modification could potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d4230c84a919d7c5a0a9b6783fafd4f
https://doi.org/10.1097/00042737-200606000-00010
https://doi.org/10.1097/00042737-200606000-00010
No genetic association of the human prolyl endopeptidase gene in the Dutch celiac disease population
Autor:
Alienke J. Monsuur, Martin C. Wapenaar, Begoña Diosdado, Lude Franke, M. L. Mearin, Dariusz Stepniak, Cisca Wijmenga, Frits Koning
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 289:G495-G500
Celiac disease (CD) is a complex genetic disorder of the small intestine. The DQ2/DQ8 human leucocyte antigen (HLA) genes explain ∼40% of the genetic component of the disease, but the remaining non-HLA genes have not yet been identified. The key en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f57c8af80cf55fafa355b1c5a30c814
https://doi.org/10.1152/ajpgi.00056.2005
https://doi.org/10.1152/ajpgi.00056.2005
Autor:
Peter A. van Veelen, Nikolaos Papandreou, Dariusz Stepniak, Antonis K. Moustakas, L. Willemijn Vader, Jan W. Drijfhout, Elias Eliopoulos, Y. Kooy, Frits Koning, George K. Papadopoulos
Publikováno v:
Immunogenetics. 57:8-15
Recent research has implicated a large number of gluten-derived peptides in the pathogenesis of celiac disease, a preponderantly HLA-DQ2-associated disorder. Current evidence indicates that the core of some of those peptides is ten amino acids long,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb1e2df3e9fb831cf627acf1717dfe6
https://doi.org/10.1007/s00251-005-0780-8
https://doi.org/10.1007/s00251-005-0780-8
Autor:
Girbe Buist, Sierd Bron, Nathalie Campo, Jörg P. Müller, Marten Veenhuis, Harold Tjalsma, Oscar P. Kuipers, Jan D. H. Jongbloed, Jan Kok, Dariusz Stepniak, Martin Westermann, Michel Meijer
Publikováno v:
Molecular Microbiology. 53:1583-1599
Most bacterial proteins destined to leave the cytoplasm are exported to extracellular compartments or imported into the cytoplasmic membrane via the highly conserved SecA-YEG pathway. In the present studies, the subcellular distributions of core comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a5f74865c738d34304edf04fef30c0a
https://doi.org/10.1111/j.1365-2958.2004.04278.x
https://doi.org/10.1111/j.1365-2958.2004.04278.x
Autor:
Jon J. van Rood, Willemijn Vader, Dariusz Stepniak, Allan Thompson, Luisa Mearin, Liesbeth Spaenij, Frits Koning, Y. Kooy
Publikováno v:
Proceedings of the National Academy of Sciences. 100:12390-12395
In patients with celiac disease, inflammatory T cell responses to HLA-DQ2-bound gluten peptides are thought to cause disease. Two types of HLA-DQ2 molecules exist, termed HLA-DQ2.5 and HLA-DQ2.2. Whereas HLA-DQ2.5 predisposes to celiac disease, HLA-D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f7a65c464cd11ca32b339fce1ab211
https://doi.org/10.1073/pnas.2135229100
https://doi.org/10.1073/pnas.2135229100