Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Dariusz Ratman"'
Autor:
Sofie J. Desmet, Jonathan Thommis, Tineke Vanderhaeghen, Edmee M.F. Vandenboorn, Dorien Clarisse, Yunkun Li, Steven Timmermans, Daria Fijalkowska, Dariusz Ratman, Evelien Van Hamme, Lode De Cauwer, Bart Staels, Luc Brunsveld, Frank Peelman, Claude Libert, Jan Tavernier, Karolien De Bosscher
Publikováno v:
Molecular Metabolism, Vol 84, Iss , Pp 101938- (2024)
Objective: The peroxisome proliferator-activated receptor α (PPARα) is a transcription factor driving target genes involved in fatty acid β-oxidation. To what extent various PPARα interacting proteins may assist its function as a transcription fa
Externí odkaz:
https://doaj.org/article/1e23832839bc4f67a6376a644117993b
Autor:
Placede Tshiaba, Dariusz Ratman, Jiayi Sun, Tate Tunstall, Robert Maier, Premal Shah, Matthew Rabinowitz, Akash Kumar, Kate Im
Publikováno v:
Genetics in Medicine Open, Vol 1, Iss 1, Pp 100361- (2023)
Externí odkaz:
https://doaj.org/article/bca8db8f638c475abebe357adb10d18f
Autor:
Nadia Bougarne, Viacheslav Mylka, Dariusz Ratman, Ilse M. Beck, Jonathan Thommis, Lode De Cauwer, Jan Tavernier, Bart Staels, Claude Libert, Karolien De Bosscher
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Glucocorticoids (GCs) act via the glucocorticoid receptor (NR3C1, GRα) to combat overshooting responses to infectious stimuli, including lipopolysaccharide (LPS). As such, GCs inhibit the activity of downstream effector cytokines, such as tumor necr
Externí odkaz:
https://doaj.org/article/b4797e86643448b58cc92f2a7121f594
Autor:
Oonagh Paerewijck, Brecht Maertens, Leentje Dreesen, Frederik Van Meulder, Iris Peelaers, Dariusz Ratman, Robert W. Li, Erik Lubberts, Karolien De Bosscher, Peter Geldhof
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract The protozoan parasite Giardia is a highly prevalent intestinal pathogen with a wide host range. Data obtained in mice, cattle and humans revealed the importance of IL-17A in the development of a protective immune response against Giardia. T
Externí odkaz:
https://doaj.org/article/ec19a01cba2d4ea98f63a20818ac59a8
Autor:
Katarzyna Szarc vel Szic, Ken Op de Beeck, Dariusz Ratman, An Wouters, Ilse M Beck, Ken Declerck, Karen Heyninck, Erik Fransen, Marc Bracke, Karolien De Bosscher, Filip Lardon, Guy Van Camp, Wim Vanden Berghe
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87850 (2014)
Withaferin A (WA) isolated from Withania somnifera (Ashwagandha) has recently become an attractive phytochemical under investigation in various preclinical studies for treatment of different cancer types. In the present study, a comparative pathway-b
Externí odkaz:
https://doaj.org/article/606a1d5280a2482984e244e0f871c4dd
Autor:
Placede Tshiaba, Jiayi Sun, Dariusz Ratman, Tate Tunstall, Brynn Levy, Premal Shah, Matthew Rabinowitz, Akash Kumar, Kate Im
Publikováno v:
Journal of Clinical Oncology. 40:10540-10540
10540 Background: Breast cancer (BC) risk is influenced by many common variants with small effects. Polygenic risk scores (PRS) weight these variants based on genome-wide association studies (GWAS) and aggregate them into a single measure. PRS has pr
Autor:
F. Van Meulder, Robert W. Li, Koen Chiers, K. De Bosscher, S. Van Coppernolle, Peter Geldhof, Dariusz Ratman, W. Van den Broeck, Edwin Claerebout, Jimmy Borloo
Publikováno v:
International Journal for Parasitology. 45:637-646
Recently we reported the successful vaccination of calves against Cooperia oncophora with a double domain activation-associated secreted protein, purified from the excretory-secretory material of adult stage parasites. In an attempt to elucidate the
Autor:
Riet De Rycke, Kris Gevaert, Viacheslav Mylka, Lode De Cauwer, Claude Libert, Julie Deckers, Wim Vanden Berghe, Jan Tavernier, Francis Impens, Jonathan Thommis, Dariusz Ratman, Karolien De Bosscher
Publikováno v:
Autophagy
AUTOPHAGY
AUTOPHAGY
Glucocorticoids are widely used to treat inflammatory disorders; however, prolonged use of glucocorticoids results in side effects including osteoporosis, diabetes and obesity. Compound A (CpdA), identified as a selective NR3C1/glucocorticoid recepto
Autor:
Karolien De Bosscher, René Houtman, Dariusz Ratman, Karlien Van Wesemael, Fritz Offner, Ilse M. Beck, Jonathan Thommis, Jan Tavernier, Dorien Clarisse
Publikováno v:
Oncotarget
ONCOTARGET
ONCOTARGET
Coregulators cooperate with nuclear receptors, such as the glucocorticoid receptor (GR), to enhance or repress transcription. These regulatory proteins are implicated in cancer, yet, their role in lymphoid malignancies, including multiple myeloma (MM
Autor:
K. De Bosscher, Jonathan Thommis, Marnik Vuylsteke, Nadia Bougarne, Sofie Desmet, René Houtman, Dariusz Ratman, Jan Tavernier, L. De Cauwer, L. Van de Moortel
Publikováno v:
SCIENTIFIC REPORTS
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
The glucocorticoid receptor (GR) is a transcription factor of which the underlying gene regulatory mechanisms are complex and incompletely understood. The non-steroidal anti-inflammatory Compound A (CpdA), a selective GR modulating compound in variou