Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Dariusz Pytel"'
Autor:
Bartosz Mucha, Shuo Qie, Sagar Bajpai, Vincenzo Tarallo, J. Nathaniel Diehl, Frank Tedeschi, Gao Zhou, Zhaofeng Gao, Samuel Flashner, Andres J. Klein-Szanto, Hanina Hibshoosh, Shimonosono Masataka, Olga S. Chajewski, Ireneusz Majsterek, Dariusz Pytel, Maria Hatzoglou, Channing J. Der, Hiroshi Nakagawa, Adam J. Bass, Kwok-Kin Wong, Serge Y. Fuchs, Anil K. Rustgi, Eckhard Jankowsky, J. Alan Diehl
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Cytoplasmic accumulation of RNA binding protein, hnRNPK in cancer cells is associated with poor prognosis. Here the authors show that SCFFbxo4 E3 ubiquitin ligase-mediated polyubiquitylation of hnRNPK restricts c-Myc translation and limits cancer pro
Externí odkaz:
https://doaj.org/article/fecd2f81e26b43a3b3aad7932728969f
Autor:
Wioletta Rozpędek-Kamińska, Grzegorz Galita, Kamil Saramowicz, Zuzanna Granek, Julia Barczuk, Natalia Siwecka, Dariusz Pytel, Ireneusz Majsterek
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 728 (2024)
The term glaucoma encompasses various neurodegenerative eye disorders, among which the most common is primary open-angle glaucoma (POAG). Recently, the essential role of human retinal astrocytes (HRA) in glaucoma progression has been placed in the sp
Externí odkaz:
https://doaj.org/article/fd3f2d429343417993b7495edfebb621
Autor:
Wioletta Rozpędek-Kamińska, Grzegorz Galita, Natalia Siwecka, Steven L. Carroll, John Alan Diehl, Ewa Kucharska, Dariusz Pytel, Ireneusz Majsterek
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4494 (2021)
Primary open-angle glaucoma (POAG) constitutes the most common type of glaucoma. Emerging evidence suggests that Endoplasmic Reticulum (ER) stress and the protein kinase RNA-like endoplasmic reticulum kinase (PERK)-mediated Unfolded Protein Response
Externí odkaz:
https://doaj.org/article/c62578b9a289483f9d5902fe21f78491
Autor:
Natalia Siwecka, Wioletta Rozpędek-Kamińska, Adam Wawrzynkiewicz, Dariusz Pytel, J. Alan Diehl, Ireneusz Majsterek
Publikováno v:
Biomedicines, Vol 9, Iss 2, p 156 (2021)
Inositol-requiring enzyme type 1 (IRE1) is a serine/threonine kinase acting as one of three branches of the Unfolded Protein Response (UPR) signaling pathway, which is activated upon endoplasmic reticulum (ER) stress conditions. It is known to be cap
Externí odkaz:
https://doaj.org/article/d374311c497a48149ed539238b9886ad
The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases
Autor:
Wioletta Rozpędek-Kamińska, Natalia Siwecka, Adam Wawrzynkiewicz, Radosław Wojtczak, Dariusz Pytel, J. Alan Diehl, Ireneusz Majsterek
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 6, p 2108 (2020)
Higher prevalence of neurodegenerative diseases is strictly connected with progressive aging of the world population. Interestingly, a broad range of age-related, neurodegenerative diseases is characterized by a common pathological mechanism—accumu
Externí odkaz:
https://doaj.org/article/deeb293eedbf45ce9d3fe680da491cf6
Autor:
Natalia Siwecka, Wioletta Rozpędek, Dariusz Pytel, Adam Wawrzynkiewicz, Adam Dziki, Łukasz Dziki, J. Alan Diehl, Ireneusz Majsterek
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 18, p 4354 (2019)
Cancer constitutes a grave problem nowadays in view of the fact that it has become one of the main causes of death worldwide. Poor clinical prognosis is presumably due to cancer cells metabolism as tumor microenvironment is affected by oxidative stre
Externí odkaz:
https://doaj.org/article/df8f655a3d2a4c2096e6c8a373f213f4
Autor:
Dariusz Pytel, Yan Gao, Katarzyna Mackiewicz, Yuliya V Katlinskaya, Kirk A Staschke, Maria C G Paredes, Akihiro Yoshida, Shuo Qie, Gao Zhang, Olga S Chajewski, Lawrence Wu, Ireneusz Majsterek, Meenhard Herlyn, Serge Y Fuchs, J Alan Diehl
Publikováno v:
PLoS Genetics, Vol 12, Iss 12, p e1006518 (2016)
The unfolded protein response (UPR) regulates cell fate following exposure of cells to endoplasmic reticulum stresses. PERK, a UPR protein kinase, regulates protein synthesis and while linked with cell survival, exhibits activities associated with bo
Externí odkaz:
https://doaj.org/article/4ced1db2d95a40098e3c80465969cbee
Autor:
Shikhar Mehrotra, Vamsi K. Gangaraju, J. Alan Diehl, Eduardo N. Maldonado, Paulo C. Rodriguez, Shilpak Chatterjee, Hong Li, Viswanathan Palanisamy, Stefano Berto, Hongjun Wang, Meenal Mehrotra, Lauren Ball, Gyda C. Beeson, Satish N. Nadig, Inhong Kang, Dariusz Pytel, Do-Sung Kim, Zachariah T. Hedley, Monika Gooz, Danh Tran, Seungho Choi, Rasesh Y. Parikh, Paramita Chakraborty
Mitochondria and endoplasmic reticulum (ER) share structural and functional networks and activate well-orchestrated signaling processes to shape cells’ fate and function. While persistent ER stress (ERS) response leads to mitochondrial collapse, mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03966e003aa062ef67f752a61daa01ba
https://doi.org/10.1158/0008-5472.c.6513793.v1
https://doi.org/10.1158/0008-5472.c.6513793.v1
Autor:
Shikhar Mehrotra, Vamsi K. Gangaraju, J. Alan Diehl, Eduardo N. Maldonado, Paulo C. Rodriguez, Shilpak Chatterjee, Hong Li, Viswanathan Palanisamy, Stefano Berto, Hongjun Wang, Meenal Mehrotra, Lauren Ball, Gyda C. Beeson, Satish N. Nadig, Inhong Kang, Dariusz Pytel, Do-Sung Kim, Zachariah T. Hedley, Monika Gooz, Danh Tran, Seungho Choi, Rasesh Y. Parikh, Paramita Chakraborty
Supplementary Figure from Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Antitumor T-cell Function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::327207eb3cc7721b863607a4a75d8d2b
https://doi.org/10.1158/0008-5472.22431067
https://doi.org/10.1158/0008-5472.22431067
Autor:
Tomasz Skorski, Janusz Blasiak, Michal O. Nowicki, Ewelina Stoczynska, Dariusz Pytel, Kimberly Cramer, Stanislaw K. Jozwiakowski, Tomasz Poplawski, Artur Slupianek
Supplementary Figures 1-4 from BCR/ABL Stimulates WRN to Promote Survival and Genomic Instability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6087ab740ea7bc1beacd4deb08fdc1e5
https://doi.org/10.1158/0008-5472.22388429
https://doi.org/10.1158/0008-5472.22388429