Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Dariusz C, Górecki"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Mortality of Duchenne Muscular Dystrophy (DMD) is a consequence of progressive wasting of skeletal and cardiac muscle, where dystrophinopathy affects not only muscle fibres but also myogenic cells. Elevated activity of P2X7 receptors and inc
Externí odkaz:
https://doaj.org/article/e1cce0c2c23a422ab87448d43fb7c223
Autor:
Cheryl A. Hawkes, Christopher J. Heath, Matthew M. Sharp, Dariusz C. Górecki, Roxana O. Carare
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-15 (2022)
Abstract α-Dystrobrevin (α-DB) is a major component of the dystrophin-associated protein complex (DAPC). Knockout (KO) of α-DB in the brain is associated with astrocytic abnormalities and loss of neuronal GABA receptor clustering. Mutations in DAP
Externí odkaz:
https://doaj.org/article/306a2ece7fcb4cad83f65ebbf1a9a1e1
Autor:
Robin M. H. Rumney, Samuel C. Robson, Alexander P. Kao, Eugen Barbu, Lukasz Bozycki, James R. Smith, Simon M. Cragg, Fay Couceiro, Rachna Parwani, Gianluca Tozzi, Michael Stuer, Asa H. Barber, Alex T. Ford, Dariusz C. Górecki
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The highest tensile strength biomaterial known exists in limpet teeth and replicating this material is of interest. Here, the authors report on the ex vivo growth of teeth and use of isolated limpet tissue and cells providing foundations for the deve
Externí odkaz:
https://doaj.org/article/26116356c05647558d51d5c078b1e93d
Autor:
Matthew MacGregor Sharp, Jordan Cassidy, Thomas Thornton, James Lyles, Abby Keable, Maureen Gatherer, Masato Yasui, Yoichiro Abe, Shinsuke Shibata, Roy O. Weller, Dariusz C. Górecki, Roxana O. Carare
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-15 (2021)
Abstract The extracellular matrix (ECM) of the cerebral vasculature provides a pathway for the flow of interstitial fluid (ISF) and solutes out of the brain by intramural periarterial drainage (IPAD). Failure of IPAD leads to protein elimination fail
Externí odkaz:
https://doaj.org/article/2973b83c1f784828863d2089c0b84b3a
Autor:
Dariusz C. Górecki
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 11, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/aa0d00a64e7b49bbbf04e93eb03b4b96
Autor:
Robin M. H. Rumney, Justyna Róg, Natalia Chira, Alexander P. Kao, Rasha Al-Khalidi, Dariusz C. Górecki
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Ectopic calcification (EC) of myofibers is a pathological feature of muscle damage in Duchenne muscular dystrophy (DMD). Mineralisation of muscle tissue occurs concomitantly with macrophage infiltration, suggesting a link between ectopic mineral depo
Externí odkaz:
https://doaj.org/article/37e4dfc22c994e55a84943a00d70969a
Autor:
Virginie Mournetas, Emmanuelle Massouridès, Jean‐Baptiste Dupont, Etienne Kornobis, Hélène Polvèche, Margot Jarrige, Alan R.L. Dorval, Maxime R.F. Gosselin, Antigoni Manousopoulou, Spiros D. Garbis, Dariusz C. Górecki, Christian Pinset
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 1, Pp 209-232 (2021)
Abstract Background Duchenne muscular dystrophy (DMD) causes severe disability of children and death of young men, with an incidence of approximately 1/5000 male births. Symptoms appear in early childhood, with a diagnosis made mostly around 4 years
Externí odkaz:
https://doaj.org/article/ea187c682a4e4ab7b9410427b1c72de3
Autor:
Rasha Al-Khalidi, Chiara Panicucci, Paul Cox, Natalia Chira, Justyna Róg, Christopher N. J. Young, Rhiannon E. McGeehan, Kameshwari Ambati, Jayakrishna Ambati, Krzysztof Zabłocki, Elisabetta Gazzerro, Stephen Arkle, Claudio Bruno, Dariusz C. Górecki
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-17 (2018)
Abstract Duchenne muscular dystrophy (DMD) is the most common inherited muscle disorder that causes severe disability and death of young men. This disease is characterized by progressive muscle degeneration aggravated by sterile inflammation and is a
Externí odkaz:
https://doaj.org/article/dd25d786045a4ae7b7f3c0189e811271
Publikováno v:
Developmental Dynamics. 252:429-438
Xenopus frogs are used extensively for modeling genetic diseases owing to characteristics such as the abundance of eggs combined with their large size, allowing easy manipulation, and rapid external embryo development enabling the examination of cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b191f61cd3d0a7b8f47b7f63b79702
https://doi.org/10.1002/dvdy.544
https://doi.org/10.1002/dvdy.544
Autor:
Nancy Alnassar, Malgorzata Borczyk, Georgia Tsagkogeorga, Michal Korostynski, Namshik Han, Dariusz C. Górecki
Publikováno v:
Cancers
Volume 15
Issue 5
Pages: 1378
Volume 15
Issue 5
Pages: 1378
Peer reviewed: True
Altered dystrophin expression was found in some tumors and recent studies identified a developmental onset of Duchenne muscular dystrophy (DMD). Given that embryogenesis and carcinogenesis share many mechanisms, we analyzed a
Altered dystrophin expression was found in some tumors and recent studies identified a developmental onset of Duchenne muscular dystrophy (DMD). Given that embryogenesis and carcinogenesis share many mechanisms, we analyzed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faecfe5a618527d380baa2c7ec4242e1
https://www.repository.cam.ac.uk/handle/1810/347170
https://www.repository.cam.ac.uk/handle/1810/347170
