Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Dariush Ajami"'
Autor:
Teri L Kissner, Gordon Ruthel, Shahabuddin Alam, Enrique Mann, Dariush Ajami, Mitra Rebek, Eileen Larkin, Stefan Fernandez, Robert G Ulrich, Sun Ping, David S Waugh, Julius Rebek, Kamal U Saikh
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40773 (2012)
Staphylococcal enterotoxin B (SEB) exposure triggers an exaggerated pro-inflammatory cytokine response that often leads to toxic shock syndrome (TSS) associated with organ failure and death. MyD88 mediates pro-inflammatory cytokine signaling induced
Externí odkaz:
https://doaj.org/article/50b5c0b07b3e4f4ea5ee96de78fc9670
Publikováno v:
Iranian Journal of Chemistry & Chemical Engineering, Vol 18, Iss 2, Pp 88-90 (1999)
In an environmentally benign solventless system, alcohols are rapidly oxidized to carbonyl compounds using hexamethylenetetramine-bromine on wet alumina under microwave irradiation.
Externí odkaz:
https://doaj.org/article/8a365a65916b4f37b09268d7125dfa84
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 6, Iss 1, p 30 (2010)
The synthesis and crystal structural characterization of new compounds 2–6 were accomplished. As a common synthetic methodology, the Diels–Alder reaction was applied to 9,9′,10,10′-tetradehydrodianthracene (TDDA) (7) to furnish the [12]annule
Externí odkaz:
https://doaj.org/article/8c5fe0ac28f64b3e868395e5d69e5b67
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 5, Iss 1, p 79 (2009)
The extensively studied trans-stilbene molecule is known to give only weak fluorescence in solution and inside loosely-fitting synthetic capsules. However, trans-stilbene has been recently studied in the context of antibody interiors, where binding r
Externí odkaz:
https://doaj.org/article/53efa88dbcb443589570287f97134997
Autor:
Kunio Saruta, Jenna M. Magat, Jinghong Li, Mitra Rebek, Joanna Thomas, Dariush Ajami, Julius Rebek, Justin P. Dumouchel, Timothy D. Bigby
Publikováno v:
The Journal of Immunology. 200:4036-4043
IL-33 and its receptor ST2 play important roles in airway inflammation and contribute to asthma onset and exacerbation. The IL-33/ST2 signaling pathway recruits adapter protein myeloid differentiation primary response 88 (MyD88) to transduce intracel
Publikováno v:
Tetrahedron Letters. 56:4824-4828
The synthesis of novel triquinoxaline-spanned cavitands with selectively oriented functional groups is described. In one instance a pyridine N-oxide functionalized cavitand was prepared as an exclusive isomer. We investigated its reactivity and forma
Autor:
Martha Hale, Dariush Ajami, Melissa Degardin, Daniel Angus Ryan, Mitra Rebek, Michael D. Cameron, Julius Rebek, Kamal U. Saikh, Shahabuddin Alam, Teri L. Kissner
Publikováno v:
Chemical biologydrug design. 90(6)
Small molecules were developed to attenuate proinflammatory cytokines resulting from activation of MyD88-mediated toll-like receptor (TLR) signaling by Francisella tularensis. Fifty-three tripeptide derivatives were synthesized to mimic a key BB-loop
Publikováno v:
Journal of Physical Organic Chemistry. 28:187-190
The binding behavior of a cavitand introduced by de Mendoza is explored with new guest species. Dimerization to hydrogen-bonded capsules occurs in the presence of appropriate guests, including alkanes, alkylated arenes, stilbenes, benzanilides, and c
Publikováno v:
Chem. Sci.. 5:4382-4387
Water-soluble deep cavitands with ionic peripheral groups take up hydrophobic guest compounds in D2O. Longer n-halides and α,ω-dihalides C7–C11, are bound and NMR is used to deduce their arrangements within the cavitand. The guests tumble rapidly
Autor:
Dariush Ajami, Julius Rebek
Publikováno v:
Supramolecular Chemistry. 25:574-580
We consider here the not-so-subtle effects of small changes in molecular modules that self-assemble into supramolecular complexes. In particular, the substitutions of methyl groups for hydrogens and the reverse have consequences far beyond simple ste