Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Darius P, Zlotos"'
Autor:
Mohamed Akmal Marzouk, Sara Greco, Florence Gbahou, Jenni Küblbeck, Nedjma Labani, Ralf Jockers, Ulrike Holzgrabe, Lisa Wiesmüller, Darius P. Zlotos
Publikováno v:
ACS Omega, Vol 9, Iss 48, Pp 47857-47871 (2024)
Externí odkaz:
https://doaj.org/article/26a46784b974474a9166cd69e73c3086
Autor:
Mariam A. El-Zohairy, Darius P. Zlotos, Martin R. Berger, Hassan H. Adwan, Yasmine M. Mandour
Publikováno v:
ACS Omega, Vol 6, Iss 16, Pp 10921-10935 (2021)
Externí odkaz:
https://doaj.org/article/4d848333a627401584bb5d844983bee1
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 67 (2022)
Hormone-dependent cancers, such as certain types of breast cancer are characterized by over-expression of estrogen receptors (ERs). Anticancer drug conjugates combining ER ligands with other classes of anticancer agents may not only benefit from dual
Externí odkaz:
https://doaj.org/article/5664b0ecdb3646efb5c7d7fb04d571c8
Publikováno v:
Biomolecules, Vol 11, Iss 7, p 981 (2021)
The genetic principle of synthetic lethality has most successfully been exploited in therapies engaging Poly-ADP-ribose-polymerase (PARP) inhibitors to treat patients with homologous recombination (HR)-defective tumors. In this work, we went a step f
Externí odkaz:
https://doaj.org/article/f6654e3bc0d74ca0aa90b5c329c8cb28
Publikováno v:
Natural Product Reports. 39:1910-1937
Covering: up to November 2021Since its isolation in 1818, strychnine has attracted the attention of a plethora of chemists and pharmacologists who have established its structure, developed total syntheses, and examined its complex pharmacology. While
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c0bf7bb7ca14c4b3c9fd2168382c26
https://doi.org/10.1039/d1np00079a
https://doi.org/10.1039/d1np00079a
Publikováno v:
IUCrData, Vol 2, Iss 10, p x171536 (2017)
The title compound, C12H10ClN3O, is a condensation product of 3-amino-2-chloropyridine and ethyl 2-aminobenzoate in which the aromatic rings are almost coplanar [dihedral angle = 2.28 (9)°] and an intramolecular N—H...O hydrogen bond occurs. In th
Externí odkaz:
https://doaj.org/article/39f401b63cac49c1bd0f28d49637f5c0
Publikováno v:
IUCrData, Vol 2, Iss 4, p x170580 (2017)
The solvated title compound, C13H8ClN3O2·CHCl3, is a product of a condensation reaction between 2-amino-N-(2-chloropyridin-3-yl)benzamide and phosgene. The presence of the chlorine substituent in the pyridine ring forces the latter to adopt a nearly
Externí odkaz:
https://doaj.org/article/d270286757b2464cb1d04608d4fa6bad
Publikováno v:
ACS Omega, Vol 6, Iss 16, Pp 10921-10935 (2021)
ACS Omega
ACS Omega
C-C chemokine receptor type 5 (CCR5) is a member of the G protein-coupled receptor. CCR5 and its interaction with chemokine ligands have been crucial for understanding and tackling human immunodeficiency virus (HIV)-1 entry into target cells. In rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df831e42348f848dc9cb5fe3c6179cc
https://doi.org/10.1021/acsomega.1c00681
https://doi.org/10.1021/acsomega.1c00681
Autor:
Carine M. Abdelmalek, Zexi Hu, Thales Kronenberger, Jenni Küblbeck, Franziska J. M. Kinnen, Salma S. Hesse, Afsin Malik, Mark Kudolo, Raimund Niess, Matthias Gehringer, Lars Zender, Paula A. Witt-Enderby, Darius P. Zlotos, Stefan A. Laufer
Publikováno v:
Journal of medicinal chemistry. 65(6)
Anticancer drug conjugates may benefit from simultaneous action at two targets potentially overcoming the drawbacks of current cancer treatment, such as insufficient efficacy, high toxicity, and development of resistance. Compared to a combination of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf5c283a2f2056ad21e1a1d7387fd8e6
https://pubmed.ncbi.nlm.nih.gov/35286086
https://pubmed.ncbi.nlm.nih.gov/35286086
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 71, Iss 5, Pp o304-o305 (2015)
The title compound, C12H9N3O, is an intermediate in the synthesis of the muscarinic M2 receptor antagonist AFDX-384. The seven-membered ring adopts a boat conformation and the dihedral angle between the planes of the aromatic rings is 41.51 (9)°. In
Externí odkaz:
https://doaj.org/article/d60636c4c41547ffbb8deb8860aafc7f