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pro vyhledávání: '"Darisbeth Rosario Lugo"'
Autor:
Irene Alfaras, Sarah J. Mitchell, Hector Mora, Darisbeth Rosario Lugo, Alessandra Warren, Ignacio Navas-Enamorado, Vickie Hoffmann, Christopher Hine, James R. Mitchell, David G. Le Couteur, Victoria C. Cogger, Michel Bernier, Rafael de Cabo
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 3, Iss 1, Pp 1-13 (2017)
Intermittent use of metformin improves healthspan in old mice Chronic daily exposure to a high dose of metformin (e.g., 1% w/w) shortens lifespan of non-diabetic mice, although in the short term this treatment confers a similar pattern of gene expres
Externí odkaz:
https://doaj.org/article/152539cd501d45ffb8c1f8e7c9698a5c
Autor:
Sarah J. Mitchell, Vickie Hoffmann, Irene Alfaras, Hector Mora, Michel Bernier, James R. Mitchell, Ignacio Navas-Enamorado, Victoria C. Cogger, David G. Le Couteur, Rafael de Cabo, Darisbeth Rosario Lugo, Christopher Hine, Alessandra Warren
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 3, Iss 1, Pp 1-13 (2017)
NPJ Aging and Mechanisms of Disease
NPJ Aging and Mechanisms of Disease
Chronic 1% metformin treatment is nephrotoxic in mice, but this dose may nonetheless confer health benefits if given intermittently rather than continuously. Here, we examined the effects of 1% metformin given every-other week (EOW) or two consecutiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e350dfc33d28d86298cceaad334470
https://doi.org/10.1038/s41514-017-0018-7
https://doi.org/10.1038/s41514-017-0018-7