Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Dario Sterker"'
Autor:
Christian Lohasz, Jacqueline Loretan, Dario Sterker, Ekkehard Görlach, Kasper Renggli, Paul Argast, Olivier Frey, Marion Wiesmann, Markus Wartmann, Martin Rausch, Andreas Hierlemann
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Understanding the pharmacokinetic/pharmacodynamic (PK/PD)-relationship of a drug candidate is key to determine effective, yet safe treatment regimens for patients. However, current testing strategies are inefficient in characterizing in vivo response
Externí odkaz:
https://doaj.org/article/c1abe40c761345fab661063030846a30
Autor:
Irmgard Hofmann, Andreas Weiss, Gaelle Elain, Maria Schwaederle, Dario Sterker, Vincent Romanet, Tobias Schmelzle, Albert Lai, Saskia M Brachmann, Mohamed Bentires-Alj, Thomas M Roberts, William R Sellers, Francesco Hofmann, Sauveur-Michel Maira
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e44146 (2012)
Activating K-RAS mutations occur at a frequency of 90% in pancreatic cancer, and to date no therapies exist targeting this oncogene. K-RAS signals via downstream effector pathways such as the MAPK and the PI3K signaling pathways, and much effort has
Externí odkaz:
https://doaj.org/article/42b844c37e6f4ea7a9239610c2270b0d
Autor:
Charles F. Voliva, William R. Sellers, Carlos García-Echeverría, Francesco Hofmann, Robert Schlegel, Christopher J. Wilson, Doriano Fabbro, Georg Martiny-Baron, Daniel Menezes, Alain De Pover, Kevin Shoemaker, Patrick Chène, Marion Dorsch, Christine Fritsch, Saskia Brachmann, Marion Wiesmann, Tobi Nagel, Daniel Guthy, Christian Schnell, Dario Sterker, Mark Knapp, Matthew Burger, Alan Huang, Sabina Pecchi, Sauveur-Michel Maira
PDF file - 504K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5217e68bb6f66bf8de1b2c62617ded0d
https://doi.org/10.1158/1535-7163.22498663.v1
https://doi.org/10.1158/1535-7163.22498663.v1
Autor:
Sauveur-Michel Maira, Francesco Hofmann, William R. Sellers, Carlos Garcia-Echeverria, Christine Fritsch, Thomas Brümmendorf, Christopher Wilson, Sebastian Bergling, Dario Sterker, Daniel Alexander Guthy, Masato Murakami, Chrystèle Henry, Vincent Romanet, Juliane Vaxelaire, Fabian Stauffer, Marc Hattenberger, Laurent Laborde, Malika Kazic-Legueux, Marcel J.J. Blommers, Audrey Kauffmann, Swann Gaulis, Julia Kleylein-Sohn, Saskia M. Brachmann
PDF file, 300KB, A. Upon infection with viral particles obtained from the pBabe-puro-myr-Akt retroviral vectors, pools were selected upon addition of puromycin and maintained in culture for several weeks. Extracts from pools were generated for the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e85719f22ad670c32e0e20ca95848c4
https://doi.org/10.1158/1535-7163.22497505.v1
https://doi.org/10.1158/1535-7163.22497505.v1
Autor:
Sauveur-Michel Maira, Francesco Hofmann, William R. Sellers, Carlos Garcia-Echeverria, Christine Fritsch, Thomas Brümmendorf, Christopher Wilson, Sebastian Bergling, Dario Sterker, Daniel Alexander Guthy, Masato Murakami, Chrystèle Henry, Vincent Romanet, Juliane Vaxelaire, Fabian Stauffer, Marc Hattenberger, Laurent Laborde, Malika Kazic-Legueux, Marcel J.J. Blommers, Audrey Kauffmann, Swann Gaulis, Julia Kleylein-Sohn, Saskia M. Brachmann
The pan-phosphoinositide 3-kinase (PI3K) inhibitor BKM120 was found, at high concentrations, to cause cell death in various cellular systems, irrespective of their level of PI3K addiction. Transcriptional and biochemical profiling studies were used t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9e949ba02432e441b240886f582f3e
https://doi.org/10.1158/1535-7163.c.6535633.v1
https://doi.org/10.1158/1535-7163.c.6535633.v1
Autor:
Diana Graus Porta, William R. Sellers, Francesco Hofmann, Jutta Blank, Pascal Furet, Robert Mah, Catherine Leblanc, Nicole Buschmann, Thomas Knoepfel, Audrey Kauffmann, Masato Murakami, Patrizia Barzaghi-Rinaudo, Youzhen Wang, Armin Wolf, Philippe Couttet, Heiko S. Schadt, Jacqueline Kinyamu-Akunda, Markus Wartmann, Mario Centeleghe, Dario Sterker, Michael Kiffe, Robin A. Fairhurst, Christelle Stamm, Alexandra Buhles, Flavia Adler, Andreas Weiss
Activity of FGF401 in biochemical kinase assays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de614aa92fc53e000078388a9034229
https://doi.org/10.1158/1535-7163.22506502.v1
https://doi.org/10.1158/1535-7163.22506502.v1
Autor:
Diana Graus Porta, William R. Sellers, Francesco Hofmann, Jutta Blank, Pascal Furet, Robert Mah, Catherine Leblanc, Nicole Buschmann, Thomas Knoepfel, Audrey Kauffmann, Masato Murakami, Patrizia Barzaghi-Rinaudo, Youzhen Wang, Armin Wolf, Philippe Couttet, Heiko S. Schadt, Jacqueline Kinyamu-Akunda, Markus Wartmann, Mario Centeleghe, Dario Sterker, Michael Kiffe, Robin A. Fairhurst, Christelle Stamm, Alexandra Buhles, Flavia Adler, Andreas Weiss
Details on materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855b9cca12680f3ffc27bb3edd85e4d5
https://doi.org/10.1158/1535-7163.22506505.v1
https://doi.org/10.1158/1535-7163.22506505.v1
Autor:
Charles F. Voliva, William R. Sellers, Carlos García-Echeverría, Francesco Hofmann, Robert Schlegel, Christopher J. Wilson, Doriano Fabbro, Georg Martiny-Baron, Daniel Menezes, Alain De Pover, Kevin Shoemaker, Patrick Chène, Marion Dorsch, Christine Fritsch, Saskia Brachmann, Marion Wiesmann, Tobi Nagel, Daniel Guthy, Christian Schnell, Dario Sterker, Mark Knapp, Matthew Burger, Alan Huang, Sabina Pecchi, Sauveur-Michel Maira
PDF file - 215K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3161654c306e2ce8d66e45bce9aaecf3
https://doi.org/10.1158/1535-7163.22498672.v1
https://doi.org/10.1158/1535-7163.22498672.v1
Autor:
Sauveur-Michel Maira, Francesco Hofmann, William R. Sellers, Carlos Garcia-Echeverria, Christine Fritsch, Thomas Brümmendorf, Christopher Wilson, Sebastian Bergling, Dario Sterker, Daniel Alexander Guthy, Masato Murakami, Chrystèle Henry, Vincent Romanet, Juliane Vaxelaire, Fabian Stauffer, Marc Hattenberger, Laurent Laborde, Malika Kazic-Legueux, Marcel J.J. Blommers, Audrey Kauffmann, Swann Gaulis, Julia Kleylein-Sohn, Saskia M. Brachmann
PDF file, 53KB, A and B. 5x105 A2058 cells were seeded in 10 cm dishes and incubated for 24 h either with increasing amounts of BKM120 (A) or with 5 �M of either GDC-0941 (B, top panel) or BEZ235 (B, bottom panel). Cells were then fixed, prepared a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a8005a8fc2499aab45393ef7ce9197
https://doi.org/10.1158/1535-7163.22497502.v1
https://doi.org/10.1158/1535-7163.22497502.v1
Autor:
Charles F. Voliva, William R. Sellers, Carlos García-Echeverría, Francesco Hofmann, Robert Schlegel, Christopher J. Wilson, Doriano Fabbro, Georg Martiny-Baron, Daniel Menezes, Alain De Pover, Kevin Shoemaker, Patrick Chène, Marion Dorsch, Christine Fritsch, Saskia Brachmann, Marion Wiesmann, Tobi Nagel, Daniel Guthy, Christian Schnell, Dario Sterker, Mark Knapp, Matthew Burger, Alan Huang, Sabina Pecchi, Sauveur-Michel Maira
PDF file - 579K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d026bfb2fc2e7457d371cee0b78835a
https://doi.org/10.1158/1535-7163.22498660.v1
https://doi.org/10.1158/1535-7163.22498660.v1