Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Dario Spigolon"'
Autor:
Dario Spigolon, D. Travis Gallagher, Adrian Velazquez-Campoy, Donatella Bulone, Jatin Narang, Pier Luigi San Biagio, Francesco Cappello, Alberto J.L. Macario, Everly Conway de Macario, Frank T. Robb
Publikováno v:
Biochemistry and Biophysics Reports, Vol 12, Iss C, Pp 66-71 (2017)
The human chaperonin complex is a ~ 1 MDa nanomachine composed of two octameric rings formed from eight similar but non-identical subunits called CCT. Here, we are elucidating the mechanism of a heritable CCT5 subunit mutation that causes profound ne
Externí odkaz:
https://doaj.org/article/c83304a489d4432581f66aefd5b7f84f
Autor:
Young Jun An, Sara E. Rowland, Jung-Hyun Na, Dario Spigolon, Seung Kon Hong, Yeo Joon Yoon, Jung-Hyun Lee, Frank T. Robb, Sun-Shin Cha
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Chaperonins (CPNs) are ATP-dependent protein-folding machines. Here the authors present the open and closed crystal structures of a Group III CPN from the thermophilic bacterium Carboxydothermus hydrogenoformans, discuss its mechanism and structurall
Externí odkaz:
https://doaj.org/article/d3341cf5c0da4ac9833bdafce3c7b169
Autor:
Alberto J.L. Macario, Adrián Velázquez-Campoy, Jatin Narang, Dario Spigolon, Frank T. Robb, Everly Conway de Macario, Donatella Bulone, Francesco Cappello, D. Travis Gallagher, Pier Luigi San Biagio
Publikováno v:
Biochemistry and Biophysics Reports, Vol 12, Iss C, Pp 66-71 (2017)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports 12 (2017): 66–71. doi:10.1016/j.bbrep.2017.07.011
info:cnr-pdr/source/autori:Spigolon D, Gallagher DT, Velazquez-Campoy A, Bulone D, Narang J, San Biagio PL, Cappello F, Macario AJL, Conway de Macario E, Robb FT/titolo:Quantitative analysis of the impact of a human pathogenic mutation on the CCT5 chaperonin subunit using a proxy archaeal ortholog/doi:10.1016%2Fj.bbrep.2017.07.011/rivista:Biochemistry and Biophysics Reports/anno:2017/pagina_da:66/pagina_a:71/intervallo_pagine:66–71/volume:12
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports 12 (2017): 66–71. doi:10.1016/j.bbrep.2017.07.011
info:cnr-pdr/source/autori:Spigolon D, Gallagher DT, Velazquez-Campoy A, Bulone D, Narang J, San Biagio PL, Cappello F, Macario AJL, Conway de Macario E, Robb FT/titolo:Quantitative analysis of the impact of a human pathogenic mutation on the CCT5 chaperonin subunit using a proxy archaeal ortholog/doi:10.1016%2Fj.bbrep.2017.07.011/rivista:Biochemistry and Biophysics Reports/anno:2017/pagina_da:66/pagina_a:71/intervallo_pagine:66–71/volume:12
The human chaperonin complex is a ~ 1 MDa nanomachine composed of two octameric rings formed from eight similar but non-identical subunits called CCT. Here, we are elucidating the mechanism of a heritable CCT5 subunit mutation that causes profound ne
Autor:
Dario Spigolon, Domenico Schillaci, Gennara Cavallaro, Maria Grazia Cusimano, Emanuela Fabiola Craparo, Gaetano Giammona, Barbara Porsio
Publikováno v:
Nanomedicine. 12:25-42
Aim: Efficacy of antibiotics in cystic fibrosis (CF) is compromised by the poor penetration through mucus barrier. This work proposes a new ‘nano-into-micro’ approach, used to obtain a combinatorial effect: achieve a sustained delivery of tobramy
Autor:
Fabio Librizzi, Claudio Canale, Fabio Bucchieri, Silvia Vilasi, Rosa Passantino, Dario Spigolon, Maria Rosalia Mangione, Pier Luigi San Biagio, Claudia Marino, Donatella Bulone, Francesco Cappello, Alberto Fucarino
Publikováno v:
Biochimica et biophysica acta. G, General subjects
1860 (2016): 2474–2483. doi:10.1016/j.bbagen.2016.07.019
info:cnr-pdr/source/autori:Mangione MR, Vilasi S, Marino C, Librizzi F, Canale C, Spigolon D, Bucchieri F, Fucarino A, Passantino R, Cappello F, Bulone D, San Biagio PL/titolo:Hsp60, amateur chaperone in amyloid-beta fibrillogenesis/doi:10.1016%2Fj.bbagen.2016.07.019/rivista:Biochimica et biophysica acta. G, General subjects (Print)/anno:2016/pagina_da:2474/pagina_a:2483/intervallo_pagine:2474–2483/volume:1860
1860 (2016): 2474–2483. doi:10.1016/j.bbagen.2016.07.019
info:cnr-pdr/source/autori:Mangione MR, Vilasi S, Marino C, Librizzi F, Canale C, Spigolon D, Bucchieri F, Fucarino A, Passantino R, Cappello F, Bulone D, San Biagio PL/titolo:Hsp60, amateur chaperone in amyloid-beta fibrillogenesis/doi:10.1016%2Fj.bbagen.2016.07.019/rivista:Biochimica et biophysica acta. G, General subjects (Print)/anno:2016/pagina_da:2474/pagina_a:2483/intervallo_pagine:2474–2483/volume:1860
BACKGROUND: Molecular chaperones are a very special class of proteins that play essential roles in many cellular processes like folding, targeting and transport of proteins. Moreover, recent evidence indicates that chaperones can act as potentially s
Autor:
Jung-Hyun Lee, Dario Spigolon, Sara E. Rowland, Jung-Hyun Na, Sun Shin Cha, Frank T. Robb, Young Jun An, Yeo Joon Yoon, Seung Kon Hong
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
NATURE COMMUNICATIONS(8)
Nature Communications
NATURE COMMUNICATIONS(8)
Nature Communications
The chaperonins (CPNs) are megadalton sized hollow complexes with two cavities that open and close to encapsulate non-native proteins. CPNs are assigned to two sequence-related groups that have distinct allosteric mechanisms. In Group I CPNs a detach
Publikováno v:
The journal of physical chemistry letters 5 (2014): 3043–3048. doi:10.1021/jz501570m
info:cnr-pdr/source/autori:Librizzi, Fabio; Carrotta, Rita; Spigolon, Dario; Bulone, Donatella; San Biagio, Pier Luigi/titolo:alpha-Casein Inhibits Insulin Amyloid Formation by Preventing the Onset of Secondary Nucleation Processes/doi:10.1021%2Fjz501570m/rivista:The journal of physical chemistry letters/anno:2014/pagina_da:3043/pagina_a:3048/intervallo_pagine:3043–3048/volume:5
info:cnr-pdr/source/autori:Librizzi, Fabio; Carrotta, Rita; Spigolon, Dario; Bulone, Donatella; San Biagio, Pier Luigi/titolo:alpha-Casein Inhibits Insulin Amyloid Formation by Preventing the Onset of Secondary Nucleation Processes/doi:10.1021%2Fjz501570m/rivista:The journal of physical chemistry letters/anno:2014/pagina_da:3043/pagina_a:3048/intervallo_pagine:3043–3048/volume:5
alpha-Casein is known to inhibit the aggregation of several proteins, including the amyloid beta-peptide, by mechanisms that are not yet completely clear. We studied its effects on insulin, a system extensively used to investigate the properties of a
Autor:
Maria Carmela Nicastro, Dario Spigolon, Rita Carrotta, Maria Grazia Ortore, Pier Luigi San Biagio, Fabio Librizzi, Donatella Bulone, Oscar Moran
Publikováno v:
Biophysical chemistry
208 (2016): 9–16. doi:10.1016/j.bpc.2015.07.010
info:cnr-pdr/source/autori:Nicastro MC, Spigolon D, Librizzi F, Moran O, Ortore MG, Bulone D, Biagio PL, Carrotta R/titolo:Amyloid beta-peptide insertion in liposomes containing GM1-cholesterol domains/doi:10.1016%2Fj.bpc.2015.07.010/rivista:Biophysical chemistry (Print)/anno:2016/pagina_da:9/pagina_a:16/intervallo_pagine:9–16/volume:208
208 (2016): 9–16. doi:10.1016/j.bpc.2015.07.010
info:cnr-pdr/source/autori:Nicastro MC, Spigolon D, Librizzi F, Moran O, Ortore MG, Bulone D, Biagio PL, Carrotta R/titolo:Amyloid beta-peptide insertion in liposomes containing GM1-cholesterol domains/doi:10.1016%2Fj.bpc.2015.07.010/rivista:Biophysical chemistry (Print)/anno:2016/pagina_da:9/pagina_a:16/intervallo_pagine:9–16/volume:208
Neuronal membrane damage is related to the early impairments appearing in Alzheimer's disease due to the interaction of the amyloid β-peptide (Aβ) with the phospholipid bilayer. In particular, the ganglioside GM1, present with cholesterol in lipid
Autor:
PierLuigi San Biagio, Dario Spigolon, Silvia Vilasi, Maria Rosalia Mangione, Donatella Bulone
Publikováno v:
Biophysical Journal. 108(2)
Heat shock protein 60kDa is a molecular chaperone (GroEL human homolog) that assists protein folding in mitochondria (mtHsp60). It is synthesized in the cell cytoplasm as a higher molecular weight precursor form (p-mtHsp60) containing a N-terminal ta
Autor:
Leonardo D'Acquisto, Antonino Parisi, Clelia Dispenza, Gabriele Adamo, Riccardo Pernice, Salvatore Stivala, Alessandro Busacca, Dario Spigolon, Maria Antonietta Sabatino
Publikováno v:
Optical Materials Express. 3:1820
We report on a novel class of optical materials for ethanol vapor sensing, based on polystyrene opals infiltrated with an innovative stimuli responsive hydrogel. We describe the fabrication process of the bare polystyrene opals and their subsequent i