Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Dario Siccardi"'
Autor:
Steve Louie, Beth A. McCormick, Hai Ning Shi, Jeffrey D. Bien, Dario Siccardi, Michael A. Pazos, Randall J. Mrsny, Karsten Gronert, Karen L. Mumy
Publikováno v:
The Journal of Immunology. 181:8044-8052
Neutrophil transmigration across mucosal surfaces contributes to dysfunction of epithelial barrier properties, a characteristic underlying many mucosal inflammatory diseases. Thus, insight into the directional movement of neutrophils across epithelia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76856962ff687064961db2191a69f1c9
https://doi.org/10.4049/jimmunol.181.11.8044
https://doi.org/10.4049/jimmunol.181.11.8044
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 294:G1392-G1400
Studies over the last decade have shown that Salmonella enterica serovar Typhimurium ( S. typhimurium) is able to preferentially locate to sites of tumor growth and modulate (shrink) the growth of many cancers. Given this unique association between S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8346c7f2bc757ddb31e4cb31f0a704b8
https://doi.org/10.1152/ajpgi.00599.2007
https://doi.org/10.1152/ajpgi.00599.2007
Publikováno v:
Advanced Drug Delivery Reviews. 57:219-235
The intestinal epithelium performs a multitude of tasks related to digestion and homeostasis. As a consequence of ingestion, this tissue must also participate in activities associated with protecting the body from potential pathogenic agents and toxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93def29a183c18d207618aa47cae5e0b
https://doi.org/10.1016/j.addr.2004.08.005
https://doi.org/10.1016/j.addr.2004.08.005
Publikováno v:
The Journal of Immunology. 173:5712-5720
Lung inflammation resulting from bacterial infection of the respiratory mucosal surface in diseases such as cystic fibrosis and pneumonia contributes significantly to the pathology. A major consequence of the inflammatory response is the recruitment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793a20c92b971c1e9db519fca4726577
https://doi.org/10.4049/jimmunol.173.9.5712
https://doi.org/10.4049/jimmunol.173.9.5712
Stereospecific chemical and enzymatic stability of phosphoramidate triester prodrugs of d4T in vitro
Publikováno v:
European Journal of Pharmaceutical Sciences. 22:25-31
The phosphoramidate triester prodrug approach is widely used to deliver nucleotide forms of nucleoside analogues into target cells. We investigated the stereoselective stability of a series of prodrugs of the anti-HIV agent 2′,3′-didehydro-2′,3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b63599510be8576336b4fb39a2505dd6
https://doi.org/10.1016/j.ejps.2004.02.006
https://doi.org/10.1016/j.ejps.2004.02.006
Autor:
Robert Snoek, Christopher McGuigan, Erik De Clercq, Sally Blewett, Dario Siccardi, Jonathan T. Erichsen, Jan Balzarini, Graciela Andrei
Publikováno v:
Antiviral Chemistry and Chemotherapy. 13:91-99
We have previously reported bicyclic furanopyrimidines as potent and selective inhibitors of varicella zoster virus (VZV) with subnanomolar activity for p-alkylphenyl substituted analogues. These compounds are highly lipophilic and of limited water s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcb066d0cc3acff43785ef01ed61d9fc
https://doi.org/10.1177/095632020201300203
https://doi.org/10.1177/095632020201300203
Publikováno v:
Pharmaceutical research. 22(5)
A peptide inhibitor of myosin light chain kinase (MLCK), termed membrane permeant inhibitor of myosin light chain kinase (PIK), has previously been demonstrated to correct paracellular barrier defects associated with in vitro cell models of infectiou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db66cf4d4d436bf719b2f360bce2fa27
https://pubmed.ncbi.nlm.nih.gov/15906163
https://pubmed.ncbi.nlm.nih.gov/15906163
Autor:
Bryan P. Hurley, Tor C. Savidge, Beth A. McCormick, James L. Madara, Randall J. Mrsny, Andrew T. Gewirtz, Dario Siccardi
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 101(19)
The mechanism by which neutrophils [polymorphonuclear leukocyte (PMNs)] are stimulated to move across epithelial barriers at mucosal surfaces has been basically unknown in biology. IL-8 has been shown to stimulate PMNs to leave the bloodstream at a l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67af01bc894c72e8b341c2757df7ad6b
https://pubmed.ncbi.nlm.nih.gov/15123795
https://pubmed.ncbi.nlm.nih.gov/15123795
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 307(3)
Nucleoside analogs are successful, widely used antiviral and anticancer therapeutics. Nucleotide prodrugs (i.e., pronucleotide) have increasingly been used to improve in vivo efficacy of nucleoside analogs. In this study, we evaluated the permeabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88f1bb01bc006503a1915bbb023d09e3
https://pubmed.ncbi.nlm.nih.gov/14557377
https://pubmed.ncbi.nlm.nih.gov/14557377
Publikováno v:
Pharmaceutical Research; May2005, Vol. 22 Issue 5, p703-709, 7p