Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Dario Livio Longo"'
Autor:
Nicla Lorito, Angela Subbiani, Alfredo Smiriglia, Marina Bacci, Francesca Bonechi, Laura Tronci, Elisabetta Romano, Alessia Corrado, Dario Livio Longo, Marta Iozzo, Luigi Ippolito, Giuseppina Comito, Elisa Giannoni, Icro Meattini, Alexandra Avgustinova, Paola Chiarugi, Angela Bachi, Andrea Morandi
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 7, Pp 1533-1559 (2024)
Abstract Triple-negative breast cancer (TNBC) has limited therapeutic options, is highly metastatic and characterized by early recurrence. Lipid metabolism is generally deregulated in TNBC and might reveal vulnerabilities to be targeted or used as bi
Externí odkaz:
https://doaj.org/article/26b9a22084be452a971cbb8677650abc
Autor:
Francesco Gammaraccio, Daisy Villano, Pietro Irrera, Annasofia A. Anemone, Antonella Carella, Alessia Corrado, Dario Livio Longo
Publikováno v:
Journal of Imaging, Vol 10, Iss 7, p 166 (2024)
CEST-MRI is an emerging imaging technique suitable for various in vivo applications, including the quantification of tumor acidosis. Traditionally, CEST contrast is calculated by asymmetry analysis, but the presence of fat signals leads to wrong cont
Externí odkaz:
https://doaj.org/article/fefab3135d4c4c7d99c391def4a13175
Autor:
Bruna Victorasso Jardim-Perassi, Pietro Irrera, Oluwaseyi E. Oluwatola, Dominique Abrahams, Veronica C. Estrella, Bryce Ordway, Samantha R. Byrne, Andrew A. Ojeda, Christopher J. Whelan, Jongphil Kim, Matthew S. Beatty, Sultan Damgaci-Erturk, Dario Livio Longo, Kim J. Gaspar, Gabrielle M. Siegers, Barbara A. Centeno, Justin Y. C. Lau, Shari A. Pilon-Thomas, Arig Ibrahim-Hashim, Robert J. Gillies
Publikováno v:
Biomedicines, Vol 12, Iss 2, p 461 (2024)
Acidosis is an important immunosuppressive mechanism that leads to tumor growth. Therefore, we investigated the neutralization of tumor acidity to improve immunotherapy response. L-DOS47, a new targeted urease immunoconjugate designed to neutralize t
Externí odkaz:
https://doaj.org/article/5a610c872c3d4c0c81b99911fe84d7cd
Autor:
Chetan Dhakan, Annasofia Anemone, Vittoria Ventura, Antonella Carella, Alessia Corrado, Elisa Pirotta, Daisy Villano, Feriel Romdhane, Francesco Gammaraccio, Silvio Aime, Dario Livio Longo
Publikováno v:
Metabolites, Vol 13, Iss 11, p 1161 (2023)
Proton transporters play a key role in maintaining the acidic tumor microenvironment; hence, their inhibition has been proposed as a new therapeutic treatment, although few methods can accurately assess their effect in vivo. In this study, we investi
Externí odkaz:
https://doaj.org/article/7a725ca6080b40f494e38275e8c0ecbc
Autor:
Hao Wu, Veronica Estrella, Matthew Beatty, Dominique Abrahams, Asmaa El-Kenawi, Shonagh Russell, Arig Ibrahim-Hashim, Dario Livio Longo, Yana K. Reshetnyak, Anna Moshnikova, Oleg A. Andreev, Kimberly Luddy, Mehdi Damaghi, Krithika Kodumudi, Smitha R. Pillai, Pedro Enriquez-Navas, Shari Pilon-Thomas, Pawel Swietach, Robert J. Gillies
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
T-cell activation primarily occurs in the lymph nodes, highly organized and specialized secondary lymphoid organs. Here the authors show that the acidic extracellular pH in lymph node paracortical zones limits cytokine production by effector T-cells,
Externí odkaz:
https://doaj.org/article/8a725d35fbca44839f00a263e2a935bc
Autor:
Pietro Irrera, Miriam Roberto, Lorena Consolino, Annasofia Anemone, Daisy Villano, Victor Navarro-Tableros, Antonella Carella, Walter Dastrù, Silvio Aime, Dario Livio Longo
Publikováno v:
Metabolites, Vol 13, Iss 1, p 48 (2022)
Novel anticancer treatments target the pH regulating system that plays a major role in tumor progression by creating an acidic microenvironment, although few studies have addressed their effect on tumor acidosis. In this study, we investigated in viv
Externí odkaz:
https://doaj.org/article/528441b4f929441890235014c9d81e88
Autor:
Lorena Consolino, Annasofia Anemone, Martina Capozza, Antonella Carella, Pietro Irrera, Alessia Corrado, Chetan Dhakan, Martina Bracesco, Dario Livio Longo
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Altered metabolism is considered a core hallmark of cancer. By monitoring in vivo metabolites changes or characterizing the tumor microenvironment, non-invasive imaging approaches play a fundamental role in elucidating several aspects of tumor biolog
Externí odkaz:
https://doaj.org/article/9cf8c46008e6493fbe3859f66c38e9a8
Autor:
Martina Capozza, Rachele Stefania, Luisa Rosas, Francesca Arena, Lorena Consolino, Annasofia Anemone, James Cimino, Dario Livio Longo, Silvio Aime
Publikováno v:
Applied Sciences, Vol 10, Iss 23, p 8313 (2020)
A novel, highly biocompatible, well soluble melanin-based probe obtained from the conjugation of melanin macromolecule to bovine serum albumin (BSA) was tested as a contrast agent for photoacoustic tumor imaging. Five soluble conjugates (PheoBSA A-E)
Externí odkaz:
https://doaj.org/article/3c5fd5074862409681c906d0efa786df
Autor:
Federica Riccardo, Giuseppina Barutello, Angela Petito, Lidia Tarone, Laura Conti, Maddalena Arigoni, Chiara Musiu, Stefania Izzo, Marco Volante, Dario Livio Longo, Irene Fiore Merighi, Mauro Papotti, Federica Cavallo, Elena Quaglino
Publikováno v:
Vaccines, Vol 8, Iss 2, p 166 (2020)
Non-small cell lung cancer (NSCLC) is still the leading cause of cancer death worldwide. Despite the introduction of tyrosine kinase inhibitors and immunotherapeutic approaches, there is still an urgent need for novel strategies to improve patient su
Externí odkaz:
https://doaj.org/article/f4a6a136ef964577b5d579452b47c262
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 8, p 1719 (2017)
Optoacoustic imaging emerged in early 1990s as a new biomedical imaging technology that generates images by illuminating tissues with short laser pulses and detecting resulting ultrasound waves. This technique takes advantage of the spectroscopic app
Externí odkaz:
https://doaj.org/article/08fb967836294686bed141c52c9cbb0d