Changes in Microbiome Dominance Are Associated With Declining Lung Function and Fluctuating Inflammation in People With Cystic Fibrosis

Autor: Dario L. Frey, Calum Bridson, Susanne Dittrich, Simon Y. Graeber, Mirjam Stahl, Sabine Wege, Felix Herth, Olaf Sommerburg, Carsten Schultz, Alexander Dalpke, Marcus A. Mall, Sébastien Boutin

Publikováno v: Frontiers in Microbiology, Vol 13 (2022)

Airway inflammation and microbiome dysbiosis are hallmarks of cystic fibrosis (CF) lung disease. However, longitudinal studies are needed to decipher which factors contribute to the long-term evolution of these key features of CF. We therefore evalua

Externí odkaz: https://doaj.org/article/65502817e3db49e7af9bc03cefffacf8

Increased Inflammatory Markers Detected in Nasal Lavage Correlate with Paranasal Sinus Abnormalities at MRI in Adolescent Patients with Cystic Fibrosis

Autor: Jaehi Chung, Felix Wünnemann, Johanna Salomon, Sébastien Boutin, Dario L. Frey, Tobias Albrecht, Cornelia Joachim, Monika Eichinger, Marcus A. Mall, Mark O. Wielpütz, Olaf Sommerburg

Publikováno v: Antioxidants, Vol 10, Iss 9, p 1412 (2021)

Chronic rhinosinusitis (CRS) is a characteristic feature of cystic fibrosis (CF) multiorgan disease and develops early in the life of patients with CF. The study aimed to correlate the inflammatory markers and the presence of structural abnormalities

Externí odkaz: https://doaj.org/article/74e49fbbda84498bbf29ab88d6e0b281

Relationship between airway dysbiosis, inflammation and lung function in adults with cystic fibrosis

Autor: Mirjam Stahl, Simon Y. Graeber, Alexander H. Dalpke, Carsten Schultz, Dario L. Frey, Olaf Sommerburg, Sabine Wege, Marcus A. Mall, Susanne A. Dittrich, Felix J.F. Herth, Sébastien Boutin

Publikováno v: Journal of Cystic Fibrosis. 20:754-760

Airway dysbiosis has been associated with lung disease severity in patients with cystic fibrosis (CF). However, the relationship between dysbiosis, airway inflammation and lung function impairement remains poorly understood. The aim of this study was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8e9c2aad1b64ac086643860ccc3bba
https://doi.org/10.1016/j.jcf.2020.12.022

Elastase Exocytosis by Airway Neutrophils Is Associated with Early Lung Damage in Children with Cystic Fibrosis

Autor: Marcus A. Mall, Luke W. Garratt, Hettie M. Janssens, Hamed Horati, Dario L. Frey, Camilla Margaroli, Stephen M. Stick, Tim Rosenow, Rabindra Tirouvanziam, Milton R. Brown, Lokesh Guglani, Bob J. Scholte, A. Susanne Dittrich, Limin Peng, Carsten Schultz, Anthony Kicic, Samuel T. Montgomery

Publikováno v: American Journal of Respiratory and Critical Care Medicine, 199(7), 873-881. American Thoracic Society
American Journal of Respiratory and Critical Care Medicine

Rationale: Neutrophils are recruited to the airways of individuals with cystic fibrosis (CF). In adolescents and adults with CF, airway neutrophils actively exocytose the primary granule protease elastase (NE), whose extracellular activity correlates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957146083e10adf86bd9be92b6d7fb03
https://doi.org/10.1164/rccm.201803-0442oc

Effects of Lumacaftor-Ivacaftor on Lung Clearance Index, Magnetic Resonance Imaging, and Airway Microbiome in Phe508del Homozygous Patients with Cystic Fibrosis

Autor: Marcus A. Mall, Mark O. Wielpütz, Hans-Ulrich Kauczor, Alexander H. Dalpke, Simon Y. Graeber, Olaf Sommerburg, Cornelia Joachim, Mirjam Stahl, Dario L. Frey, Sébastien Boutin, Sabine Wege

Publikováno v: Annals of the American Thoracic Society. 18(6)

Rationale: Previous studies showed that lumacaftor–ivacaftor therapy results in partial rescue of CFTR (cystic fibrosis [CF] transmembrane conductance regulator) activity and a moderate improvement...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d495120bb016c0c7146e74a3415ce35
https://pubmed.ncbi.nlm.nih.gov/33600745