Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Dario Ghigo"'
Autor:
Ivana Campia, Ilaria Buondonno, Barbara Castella, Barbara Rolando, Joanna Kopecka, Elena Gazzano, Dario Ghigo, Chiara Riganti
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126159 (2015)
Multidrug resistant cancer cells are hard to eradicate for the inefficacy of conventional anticancer drugs. Besides escaping the cytotoxic effects of chemotherapy, they also bypass the pro-immunogenic effects induced by anticancer drugs: indeed they
Externí odkaz:
https://doaj.org/article/d45860bec12c4c2faf1d4485d3fb1756
Autor:
Chiara Riganti, Barbara Castella, Joanna Kopecka, Ivana Campia, Marta Coscia, Gianpiero Pescarmona, Amalia Bosia, Dario Ghigo, Massimo Massaia
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60975 (2013)
Durable tumor cell eradication by chemotherapy is challenged by the development of multidrug-resistance (MDR) and the failure to induce immunogenic cell death. The aim of this work was to investigate whether MDR and immunogenic cell death share a com
Externí odkaz:
https://doaj.org/article/e5c66e89e2554cf99103ab0df62d0f10
Autor:
Manuela Polimeni, Ingrid Corazzari, Bice Fubini, Dario Ghigo, Cristina Pavan, Francesco Turci, Maura Tomatis
Publikováno v:
Toxicological Sciences. 153:4-17
New outbursts of silicosis were recently reported among workers manufacturing an engineered material known as "artificial stone," composed by high percentages of quartz (up to 98%) agglomerated with pigments and polymeric resins. Dusts released by ab
Autor:
Marilù Fanelli, Daniela Cortese, Massimo Serra, Dario Ghigo, Ilaria Buondonno, Claudia Maria Hattinger, Loretta Lazzarato, Elena Gazzano, Chiara Riganti, Roberta Fruttero, Alberto Gasco, Barbara Rolando, Konstantin Chegaev
Publikováno v:
Journal of Medicinal Chemistry. 59:4881-4889
Doxorubicin (DOXO) is one of the most effective antineoplastic agents in clinical practice. Its use is limited by acute and chronic side effects, in particular by its cardiotoxicity and by the rapid development of resistance to it. As part of a progr
Autor:
Dario Ghigo, Barbara Rolando, Lorenzo Annaratone, Chiara Riganti, Marco Blangetti, Konstantin Chegaev, Elena Gazzano, Roberta Fruttero
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:967-975
A library of nitric oxide-donor doxorubicins (NO-DOXOs) was synthesized by linking appropriate NO-donor moieties at C-14 position through an ester bridge. Their hydrolytic stability was evaluated. The intracellular accumulation and cytotoxicity of th
Development of sigma-1 (σ 1 ) receptor fluorescent ligands as versatile tools to study σ 1 receptors
Autor:
Dario Ghigo, Arnold E. Ruoho, Chiara Riganti, Francesco Berardi, Lian-Wang Guo, Carmen Abate, Timur A. Mavlyutov, Maria Laura Pati
Publikováno v:
European Journal of Medicinal Chemistry. 108:577-585
Despite their controversial physiology, sigma-1 (σ1) receptors are intriguing targets for the development of therapeutic agents for central nervous system diseases. With the aim of providing versatile pharmacological tools to study σ1 receptors, we
Autor:
Chiara Riganti, Marco Volante, Joanna Kopecka, Giulia Rossana Gulino, Elena Gazzano, Dario Ghigo
Publikováno v:
Cancer Letters. 360:219-226
Standard chemotherapeutic protocols, based on maximum tolerated doses, do not prevent nor overcome chemoresistance caused by the efflux transporter P-glycoprotein (Pgp). We compared the effects of two consecutive low doses versus a single high dose o
Publikováno v:
ChemBioChem. 16:1078-1083
Although sigma-2 (σ2 ) receptors are still enigmatic proteins, they are promising targets for tumor treatment and diagnosis. With the aim of clarifying their role in oncology, we developed a σ2 -selective fluorescent tracer (compound 5) as a specif
Autor:
Barbara Rolando, Silvia Arpicco, Dario Ghigo, Chiara Riganti, Konstantin Chegaev, Alessandro Marengo, Isabella Pedrini, Roberta Fruttero, Joanna Kopecka, Elena Gazzano
Publikováno v:
Molecular Pharmaceutics. 11:3068-3079
In this work we prepared and characterized two liposomal formulations of a semisynthetic nitric oxide (NO)-releasing doxorubicin (Dox), called nitrooxy-Dox (NitDox), which we previously demonstrated to be cytotoxic in Dox-resistant human colon cancer
Autor:
Giovanni Maina, Enrica Verne, Marta Miola, Dario Ghigo, Giuliana Muzio, Marina Maggiora, Chiara Vitale Brovarone, Loredana Bergandi, Federica Rossi, S. Saracino, Rosa Angela Canuto
Publikováno v:
Materials Science and Engineering: C. 38:107-118
A glass belonging to the system SiO2-P2O5-CaO-MgO-Na2O-K2O was modified by introducing two different amounts of manganese oxide (MnO). Mn-doped glasses were prepared by melt and quenching technique and characterized by means of X-ray diffraction (XRD