Výsledky vyhledávání - "Dario Gallotta"

Unusual Fernane and Gammacerane Glycosides from the Aerial Parts of Spergula fallax

Autor: Anna Stochmal, Sylwia Pawelec, Dario Gallotta, Lukasz Pecio, Usama A. Mahalel, Milena Masullo, Arafa I. Hamed, Sonia Piacente

Publikováno v: Journal of Natural Products. 77:657-662

The aerial parts of Spergula fallax afforded four glycosides (1-4) based on two new triterpene aglycones (1a and 2a), along with the known hopane glycoside succulentoside A. Compound 1 was identified as belonging to the fernane class, unusual migrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ad15f518b3e0f3a6bc3bf16857b5db
https://doi.org/10.1021/np4008415

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Saponins with highly hydroxylated oleanane-type aglycones from Silphium asteriscus L

Autor: Milena Masullo, Dario Gallotta, Sonia Piacente, Lalita M. Calabria, Cosimo Pizza

Publikováno v: Phytochemistry. 97:70-80

Silphium asteriscus L., commonly known as starry rosinweed, is a plant found in prairies, glades, woodlands and savannas of the southeastern United States. The phytochemical investigation of the methanolic extract of S. asteriscus leaves led to the i

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https://doi.org/10.1016/j.phytochem.2013.10.013

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Effect of sesquiterpene lactone coronopilin on leukaemia cell population growth, cell type-specific induction of apoptosis and mitotic catastrophe

Autor: Dario Gallotta, N. De Tommasi, R. Fortunato, Maria Antonietta Belisario, Roberta Cotugno, Alessandra Braca, Antonietta Santoro

Publikováno v: Cell Proliferation. 45:53-65

Objectives: The aim of this study was to investigate anti-leukaemic potential of coronopilin, a sesquiterpene lactone from Ambrosia arborescens, and to characterize mechanism(s) underlying its activity. Materials and methods: The study was conducted

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https://doi.org/10.1111/j.1365-2184.2011.00796.x

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Inhibition of the thioredoxin system is a basis for the antileukemic potential of 13-hydroxy-15-oxo-zoapatlin

Autor: Patrizia Nigro, Maria Antonietta Belisario, Nunziatina De Tommasi, Fabrizio Dal Piaz, Dario Gallotta

Publikováno v: Free Radical Biology and Medicine. 45:875-884

The mammalian thioredoxin (Trx) system, composed of Trx, Trx reductase (TrxR), and NADPH, is the most important thiol system involved in the redox control of signaling and regulatory proteins in apoptosis and cell proliferation. Here we addressed the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4c5f2ce71c13cdf474f4774610605d6
https://doi.org/10.1016/j.freeradbiomed.2008.06.015

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BAG3 protects bovine papillomavirus type 1-transformed equine fibroblasts against pro-death signals

Autor: Gennaro Altamura, Morena d'Avenia, Giuseppe Borzacchiello, Annunziata Corteggio, Roberta Cotugno, Dario Gallotta, Franco Roperto, Maria Antonietta Belisario

Publikováno v: Veterinary Research

In human cancer cells, BAG3 protein is known to sustain cell survival. Here, for the first time, we demonstrate the expression of BAG3 protein both in equine sarcoids in vivo and in EqS04b cells, a sarcoid-derived fully transformed cell line harbouri

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https://pubmed.ncbi.nlm.nih.gov/23876161

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BAG3 down-modulation sensitizes HPV18+ HeLa cells to PEITC-induced apoptosis and restores p53

Autor: Dario Gallotta, Roberta Cotugno, Anna Basile, Maria Antonietta Belisario, Elena Romano

Publikováno v: Cancer Letters

Highlights • BAG3 down-modulation by siRNA technology restored p53. • Reduced BAG3 expression sensitized HeLa but not C33A (HPV-negative) cells to PEITC. • Reduced BAG3 expression was associated with a decrease of E6 viral protein levels.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a89c8325a7d4cd48b975835068acbb0a
http://hdl.handle.net/11386/4449657

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Powerful tumor cell growth-inhibiting activity of a synthetic derivative of atractyligenin: Involvement of PI3K/Akt pathway and thioredoxin system

Autor: Roberta Cotugno, Fabrizio Dal Piaz, Maria Antonietta Belisario, Dario Gallotta, Sandro De Falco, Ivana Apicella, Sergio Rosselli, Maurizio Bruno

Publikováno v: Biochimica et biophysica acta. G, General subjects
1840 (2014): 1135–1144. doi:10.1016/j.bbagen.2013.11.023
info:cnr-pdr/source/autori:Cotugno, Roberta; Gallotta, Dario; Dal Piaz, Fabrizio; Apicella, Ivana; De Falco, Sandro; Rosselli, Sergio; Bruno, Maurizio; Belisario, Maria Antonietta/titolo:Powerful tumor cell growth-inhibiting activity of a synthetic derivative of atractyligenin: Involvement of PI3K%2FAkt pathway and thioredoxin system/doi:10.1016%2Fj.bbagen.2013.11.023/rivista:Biochimica et biophysica acta. G, General subjects (Print)/anno:2014/pagina_da:1135/pagina_a:1144/intervallo_pagine:1135–1144/volume:1840

The semi-synthetic ent-kaurane 15-ketoatractyligenin methyl ester (SC2017) has been previously reported to possess high antiproliferative activity against several solid tumor-derived cell lines. Our study was aimed at investigating SC2017 tumor growt

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http://hdl.handle.net/10447/96985

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