Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Dario F, De Jesus"'
Autor:
Xuanchun Wang, Yanliang Li, Guifen Qiang, Kaihua Wang, Jiarong Dai, Maximilian McCann, Marcos D. Munoz, Victoria Gil, Yifei Yu, Shengxian Li, Zhihong Yang, Shanshan Xu, Jose Cordoba-Chacon, Dario F. De Jesus, Bei Sun, Kuangyang Chen, Yahao Wang, Xiaoxia Liu, Qing Miao, Linuo Zhou, Renming Hu, Qiang Ding, Rohit N. Kulkarni, Daming Gao, Matthias Blüher, Chong Wee Liew
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Secreted isoform of endoplasmic reticulum membrane complex subunit 10 (scEMC10) is a secreted protein of incompletely understood physiological function. Here the authors show that scEMC10 is upregulated in people with obesity, and that that genetic E
Externí odkaz:
https://doaj.org/article/5b0502f9dec14a5fa157af171c82f84a
Autor:
Sevim Kahraman, Kimitaka Shibue, Dario F De Jesus, Hyunki Kim, Jiang Hu, Debasish Manna, Bridget Wagner, Amit Choudhary, Rohit N Kulkarni
Publikováno v:
eLife, Vol 12 (2023)
Pancreatic α-cells secrete glucagon, an insulin counter-regulatory peptide hormone critical for the maintenance of glucose homeostasis. Investigation of the function of human α-cells remains a challenge due to the lack of cost-effective purificatio
Externí odkaz:
https://doaj.org/article/b75a7103ed324acca5108365e616c62c
Autor:
Jun Shirakawa, Yu Togashi, Giorgio Basile, Tomoko Okuyama, Ryota Inoue, Megan Fernandez, Mayu Kyohara, Dario F. De Jesus, Nozomi Goto, Wei Zhang, Takahiro Tsuno, Tatsuya Kin, Hui Pan, Jonathan M. Dreyfuss, A.M. James Shapiro, Peng Yi, Yasuo Terauchi, Rohit N. Kulkarni
Publikováno v:
Cell Reports, Vol 41, Iss 1, Pp 111436- (2022)
Summary: Prevention or amelioration of declining β cell mass is a potential strategy to cure diabetes. Here, we report the pathways utilized by β cells to robustly replicate in response to acute insulin resistance induced by S961, a pharmacological
Externí odkaz:
https://doaj.org/article/3143a9f198114e48a593ab4fa7acda69
Autor:
Marta Pradas-Juni, Nils R. Hansmeier, Jenny C. Link, Elena Schmidt, Bjørk Ditlev Larsen, Paul Klemm, Nicola Meola, Hande Topel, Rute Loureiro, Ines Dhaouadi, Christoph A. Kiefer, Robin Schwarzer, Sajjad Khani, Matteo Oliverio, Motoharu Awazawa, Peter Frommolt, Joerg Heeren, Ludger Scheja, Markus Heine, Christoph Dieterich, Hildegard Büning, Ling Yang, Haiming Cao, Dario F. De Jesus, Rohit N. Kulkarni, Branko Zevnik, Simon E. Tröder, Uwe Knippschild, Peter A. Edwards, Richard G. Lee, Masayuki Yamamoto, Igor Ulitsky, Eduardo Fernandez-Rebollo, Thomas Q. de Aguiar Vallim, Jan-Wilhelm Kornfeld
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Despite widespread transcription of LncRNA in mammalian systems, their contribution to metabolic homeostasis at the cellular and tissue level remains elusive. Here Pradas-Juni et al. describe a transcription factor–LncRNA pathway that couples hepat
Externí odkaz:
https://doaj.org/article/4ccddec6eb3c494894508ff7177b7683
Autor:
Zijie Zhang, Qi Zhan, Mark Eckert, Allen Zhu, Agnieszka Chryplewicz, Dario F. De Jesus, Decheng Ren, Rohit N. Kulkarni, Ernst Lengyel, Chuan He, Mengjie Chen
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-17 (2019)
Abstract Epitranscriptome profiling using MeRIP-seq is a powerful technique for in vivo functional studies of reversible RNA modifications. We develop RADAR, a comprehensive analytical tool for detecting differentially methylated loci in MeRIP-seq da
Externí odkaz:
https://doaj.org/article/034a399bc5b94967bd10e5e307ab8404
Autor:
Manoj K. Gupta, Dario F. De Jesus, Sevim Kahraman, Ivan A. Valdez, Farnaz Shamsi, Lian Yi, Adam C. Swensen, Yu-Hua Tseng, Wei-Jun Qian, Rohit N. Kulkarni
Publikováno v:
Molecular Metabolism, Vol 18, Iss , Pp 153-163 (2018)
Objectives: Insulin receptor (IR)-mediated signaling is involved in the regulation of pluripotent stem cells; however, its direct effects on regulating the maintenance of pluripotency and lineage development are not fully understood. The main objecti
Externí odkaz:
https://doaj.org/article/ed089cc8fe424187a8b0aa0f368d3df0
Autor:
Dario F. De Jesus, Rohit N. Kulkarni
Publikováno v:
Molecular Metabolism, Vol 27, Iss , Pp S42-S48 (2019)
Background: Pancreatic β-cells adapt to high metabolic demand by expanding their β-cell mass and/or enhancing insulin secretion to maintain glucose homeostasis. Type 2 diabetes (T2D) is typically characterized by β-cell decompensation. Scope of th
Externí odkaz:
https://doaj.org/article/41f8a91af9844b95b00127ba7d26f078
Autor:
Ling Xiao, Dario F. De Jesus, Cheng-Wei Ju, Jiang-Bo Wei, Jiang Hu, Ava DiStefano-Forti, Tadataka Tsuji, Cheryl Cero, Ville Männistö, Suvi M. Manninen, Siying Wei, Oluwaseun Ijaduola, Matthias Blüher, Aaron M. Cypess, Jussi Pihlajamäki, Yu-Hua Tseng, Chuan He, Rohit N. Kulkarni
Publikováno v:
bioRxiv
SummaryBrown adipose tissue (BAT) has the capacity to regulate systemic metabolism through the secretion of signaling lipids. N6-methyladenosine (m6A) is the most prevalent and abundant post-transcriptional mRNA modification and has been reported to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf4fddf70655d42ce1538dbad8d716e
https://europepmc.org/articles/PMC10245942/
https://europepmc.org/articles/PMC10245942/
Autor:
Sevim Kahraman, Kimitaka Shibue, Dario F. De Jesus, Jiang Hu, Debasish Manna, Bridget K. Wagner, Amit Choudhary, Rohit N. Kulkarni
Pancreatic α-cells secrete glucagon, an insulin counter-regulatory peptide hormone critical for the maintenance of glucose homeostasis. Investigation of the function of human α-cells remains a challenge due to the lack of cost-effective purificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6e589fe985591b7b2a0adb956cd6193
https://doi.org/10.1101/2022.11.27.518097
https://doi.org/10.1101/2022.11.27.518097
Autor:
GIORGIO BASILE, AMEDEO VETERE, JIANG HU, OLUWASEUN IJADUOLA, DARIO F. DE JESUS, KAZUKI FUKUDA, AMIRA M. ELTONY, ANDY YUN, AMIT CHOUDHARY, BRIDGET WAGNER, ROHIT KULKARNI
Publikováno v:
Diabetes. 71
The discovery of SerpinB1 as an inducer of human β-cell proliferation pointed to acinar cell-derived proteases such as pancreatic elastase (PE) being involved in regulating β-cell viability. Indeed, we observed that expression of a major form of PE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6861a22c5ac404e54e9b4ec0ac0d23cb
https://doi.org/10.2337/db22-247-lb
https://doi.org/10.2337/db22-247-lb