Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Dario Doller"'
Publikováno v:
Expert Opinion on Investigational Drugs. 29:1323-1338
Approximately 40% of Parkinson's disease (PD) patients that take mostly dopamine receptor agonists for motor fluctuations, experience the return of symptoms between regular doses. This is a phenomenon known as 'OFF periods.' Positive allosteric modul
Autor:
Dario, Doller, Paul, Wes
Publikováno v:
Handbook of experimental pharmacology. 257
Drug discovery research is a complex undertaking conducted by teams of scientists representing the different areas involved. In addition to a strong familiarity with existing knowledge, key relevant concepts remain unknown as activities start. This i
Autor:
Maria-Jesus Blanco, Quinn Coughlin, Dario Doller, Hopper Allen T, Robichaud Albert Jean, Vijaya Tirunagaru
Publikováno v:
Journal of medicinal chemistry. 62(13)
Medicinal chemists are accountable for embedding the appropriate drug target profile into the molecular architecture of a clinical candidate. An accurate characterization of the functional effects following binding of a drug to its biological target
Autor:
Paul D. Wes, Dario Doller
Publikováno v:
Good Research Practice in Non-Clinical Pharmacology and Biomedicine ISBN: 9783030336554
Drug discovery research is a complex undertaking conducted by teams of scientists representing the different areas involved. In addition to a strong familiarity with existing knowledge, key relevant concepts remain unknown as activities start. This i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04460e0fd9df4abaedbbbef740779dfb
https://doi.org/10.1007/164_2019_281
https://doi.org/10.1007/164_2019_281
Autor:
Dario Doller
Publikováno v:
2017 Medicinal Chemistry Reviews ISBN: 9780996293242
2017 Medicinal Chemistry Reviews
2017 Medicinal Chemistry Reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cccb6b298e338be610cb12370d4dc2a
https://doi.org/10.29200/acsmedchemrev-v52.ch18
https://doi.org/10.29200/acsmedchemrev-v52.ch18
Autor:
Dario Doller
Although the concept of allosterism has been known for over half a century, its application in drug discovery has exploded in recent years. The emergence of novel technologies that enable molecular-level ligand-receptor interactions to be studied in
Autor:
Dario Doller
Publikováno v:
ACS chemical neuroscience. 8(1)
Society expects that the wave of contemporary new discoveries in biological sciences will soon lead to novel treatments for human diseases, including many devastating brain disorders. Historically, medicinal chemists have contributed to drug discover
Autor:
Scott L. Harbeson, Christopher L. Brummel, Dario Doller, Julie F. Liu, Robert H. Silverman, Roger D. Tung
The use of deuterium substitution in an effort to produce kinetic isotope effects (KIEs) that favorably alter pharmacokinetics and metabolism in drug discovery has accelerated in the last decade. While the effects of deuteration remain highly experim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea2fbe425fc282af194b33f639572cfb
https://doi.org/10.1016/bs.armc.2017.08.010
https://doi.org/10.1016/bs.armc.2017.08.010
Publikováno v:
Current Topics in Medicinal Chemistry. 14:1755-1770
Drug design necessitates a clear understanding of the phenotypic response to be elicited by a given ligandtarget interaction. This relationship is relatively well understood for classical biological targets of drug action, but for some novel targets,