Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Dario Cerletti"'
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Excess antigenic exposure, such as in cancers or chronic viral infection, can lead to T cell exhaustion. Here the authors show that despite high exposure to antigen in the context of chronic LCMV infection in mice, exhausted CD8+ T cells have low lev
Externí odkaz:
https://doaj.org/article/0847b4efc9ab451ba66c78afdb12de6e
Autor:
Ioana Sandu, Dario Cerletti, Nathalie Oetiker, Mariana Borsa, Franziska Wagen, Ilaria Spadafora, Suzanne P.M. Welten, Ugne Stolz, Annette Oxenius, Manfred Claassen
Publikováno v:
Cell Reports, Vol 32, Iss 8, Pp 108078- (2020)
Summary: A hallmark of chronic infections is the presence of exhausted CD8 T cells, characterized by a distinct transcriptional program compared with functional effector or memory cells, co-expression of multiple inhibitory receptors, and impaired ef
Externí odkaz:
https://doaj.org/article/d6da9e5548be4a6f82dcc718fcd85cb0
Autor:
Quentin Garrido, Sebastian Damrich, Alexander Jäger, Dario Cerletti, Manfred Claassen, Laurent Najman, Fred A Hamprecht
Publikováno v:
Bioinformatics
Bioinformatics, Oxford University Press (OUP), In press
Bioinformatics, Oxford University Press (OUP), In press
Motivation Single-cell RNA sequencing (scRNA-seq) allows studying the development of cells in unprecedented detail. Given that many cellular differentiation processes are hierarchical, their scRNA-seq data are expected to be approximately tree-shaped
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065e442cff7c5f3af632b26df056e399
http://arxiv.org/abs/2102.05892
http://arxiv.org/abs/2102.05892
In chronic infections CD8+ T cells acquire a state termed “exhaustion” which is characterized by impaired effector functions and expression of co-inhibitory receptors as response to continuous TCR stimulation. Recently, the pool of exhausted T ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fec9d1872ed2701ffd7cdfc82912cf12
https://doi.org/10.1101/2020.12.22.423929
https://doi.org/10.1101/2020.12.22.423929
Unsupervised trajectory inference from single cell RNA sequencing data bears the potential to systematically reconstruct complex differentiation processes but remains challenging notwithstanding the many available solutions. In general, trajectory an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e7b195e085daa49eb86792470a5aac0
https://doi.org/10.1101/2020.12.21.423801
https://doi.org/10.1101/2020.12.21.423801
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 117 (17)
Proceedings of the National Academy of Sciences of the United States of America, 117 (17)
Understanding how bacteria colonize surfaces and regulate cell-cycle progression in response to cellular adhesion is of fundamental importance. Here, we use transposon sequencing in conjunction with fluorescence resonance energy transfer (FRET) micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ce18dabe04e1bf2d0a45c94b70ee9e
Understanding how bacteria colonize surfaces and regulate cell cycle progression in response to cellular adhesion is of fundamental importance. Here, we used transposon sequencing in conjunction with FRET microscopy to uncover the molecular mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1af9d0414c5f3a75d65b49737635c5b
Autor:
Mariana Borsa, Nathalie Oetiker, Ilaria Spadafora, Dario Cerletti, Ugne Stolz, Annette Oxenius, Manfred Claassen, Suzanne P. M. Welten, Ioana Sandu, Franziska Wagen
Publikováno v:
Cell Reports, 32 (8)
Cell Reports, Vol 32, Iss 8, Pp 108078-(2020)
Cell Reports, Vol 32, Iss 8, Pp 108078-(2020)
A hallmark of chronic infections is the presence of exhausted CD8 T cells, characterized by a distinct transcriptional program compared with functional effector or memory cells, co-expression of multiple inhibitory receptors, and impaired effector fu
Autor:
Christian M. Beusch, Dario Cerletti, Yvonne Bösch, Luca Del Medico, Carlos Eduardo Flores-Tinoco, Matthias Christen, Flavia Tschan, Beat Christen
Publikováno v:
Journal of Molecular Biology, 428 (2)
Classical molecular genetics uses stringent selective conditions to identify mutants with distinct phenotypic responses. Mutations giving rise to less pronounced phenotypes are often missed. However, to gain systems-level insights into complex geneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db63c7991f8ea19ccbb7164aba973ad
https://hdl.handle.net/20.500.11850/113399
https://hdl.handle.net/20.500.11850/113399