Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Dario, Lehoux"'
Publikováno v:
BMC Research Notes, Vol 16, Iss 1, Pp 1-5 (2023)
Abstract Orthopedic foreign body-associated infection can be difficult to treat due to the formation of biofilms protecting microorganisms from both antimicrobials and the immune system. Exebacase is an antistaphylococcal lysin (cell wall hydrolase)
Externí odkaz:
https://doaj.org/article/bcc21f6ce9994321aedb1b16301e5b48
Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 2, Pp n/a-n/a (2023)
Abstract Inclisiran, a small interfering RNA, selectively inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9) synthesis in the liver and has been shown to reduce low‐density lipoprotein cholesterol (LDL‐C) by ≥50% in patients with hy
Externí odkaz:
https://doaj.org/article/b10d010fc2974f3d86fce60390f08379
Autor:
Melissa Karau, Suzannah Schmidt-Malan, Jay Mandrekar, Dario Lehoux, Raymond Schuch, Cara Cassino, Robin Patel
Introduction: Staphylococcus aureus is the most common cause of orthopedic infections and can be challenging to treat, especially in the presence of a foreign body. The antistaphylococcal lysins exebacase and CF-296 have rapid bactericidal activity,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743fdd002bbaf06b033498ed5043713a
https://jbji.copernicus.org/articles/7/169/2022/
https://jbji.copernicus.org/articles/7/169/2022/
Autor:
Razieh Kebriaei, Kyle Stamper, Raymond Schuch, Katherine L. Lev, Michael J. Rybak, Jacinda C Abdul-Mutakabbir, Dario Lehoux, Taylor Morrisette
Publikováno v:
Antimicrob Agents Chemother
Exebacase is a lysin (cell wall hydrolase) with direct lytic activity against Staphylococcus aureus including methicillin-resistant S. aureus (MRSA). Time-kill analysis experiments illustrated bactericidal activity of exebacase-daptomycin against MRS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d2c0c80c7907e248e954bb691c9bee
https://europepmc.org/articles/PMC8522749/
https://europepmc.org/articles/PMC8522749/
Publikováno v:
Toxicology and applied pharmacology. 443
Inclisiran is a small interfering RNA molecule that was designed to reduce plasma low-density lipoprotein cholesterol (LDL-C) levels by inhibiting proprotein convertase subtilisin/kexin type 9 synthesis in the liver. This study aimed to characterize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::794012e0803140dba8a90d29e6cf5de0
https://pubmed.ncbi.nlm.nih.gov/35780943
https://pubmed.ncbi.nlm.nih.gov/35780943
Publikováno v:
Toxicology and Applied Pharmacology. 451:116144
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddcb9c4f06c86996ab4a51447b10d0ba
https://doi.org/10.1016/j.taap.2022.116144
https://doi.org/10.1016/j.taap.2022.116144
Autor:
Dario Lehoux, Megan McGrath, Brad Zerler, Douglas E. Raines, Beatrijs I. Valk, John J. A. Marota
Publikováno v:
Anesthesiology, 131(2), 287-304. LIPPINCOTT WILLIAMS & WILKINS
Editor's PerspectiveWhat We Already Know about This Topic The investigational etomidate analog ABP-700 causes involuntary muscle movements in humans at anesthetic doses and seizures in dogs at 10-fold higher toxicologic doses The mechanism of seizure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6bad0378de25fc0ed4b4edf431ac4f8
https://doi.org/10.1097/aln.0000000000002758
https://doi.org/10.1097/aln.0000000000002758
Autor:
Robin Patel, Raymond Schuch, Jay Mandrekar, Suzannah M. Schmidt-Malan, Cara Cassino, Dario Lehoux, Melissa J. Karau
Publikováno v:
Antimicrob Agents Chemother
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b76876ed733af7572df0d5b48708c9
https://doi.org/10.1128/aac.00117-21
https://doi.org/10.1128/aac.00117-21
Autor:
David P. Nicolau, Raymond Schuch, Nicole A DeRosa, Cara Cassino, Tomefa E. Asempa, Dario Lehoux
Publikováno v:
The Journal of antimicrobial chemotherapy. 76(10)
Objectives CF-296 is a lysin in pre-clinical development for the treatment of MSSA and MRSA infections, used in addition to standard-of-care (SOC) antibiotics. We evaluated the efficacy of CF-296 alone and in addition to daptomycin or vancomycin agai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dbe9f388a27fa7716ea219ed532cfdc
https://pubmed.ncbi.nlm.nih.gov/34223628
https://pubmed.ncbi.nlm.nih.gov/34223628
Publikováno v:
Toxicology and Applied Pharmacology. 443:115978
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8e1eefb286822295f94e8655b023025
https://doi.org/10.1016/j.taap.2022.115978
https://doi.org/10.1016/j.taap.2022.115978