Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Darina L. Lazarova"'
Autor:
Darina L. Lazarova, Michael Bordonaro
Publikováno v:
Journal of Cancer
The multiple-hit hypothesis of cancer, including colorectal cancer (CRC), states that neoplastic development requires a sequence of mutations and epigenetic changes in driver genes. We have previously proposed that obesity increases CRC risk by suppo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4136325c639fcac97ae0ddb5d3f09e5f
https://doi.org/10.7150/jca.63676
https://doi.org/10.7150/jca.63676
Autor:
Darina L. Lazarova, Michael Bordonaro
Publikováno v:
Journal of Cancer
Deregulated Wnt signaling initiates most cases of colorectal cancer (CRC). Butyrate, a product of dietary fiber, hyperactivates Wnt signaling, resulting in induction of CRC cell apoptosis, which may in part explain the protective action of fiber. Non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9904b62bc5e86eb761f9e088ef8e5e9a
https://doi.org/10.7150/jca.28331
https://doi.org/10.7150/jca.28331
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115068 (2014)
Mutations in the WNT/beta-catenin pathway are present in the majority of all sporadic colorectal cancers (CRCs), and histone deacetylase inhibitors induce apoptosis in CRC cells with such mutations. This apoptosis is counteracted by (1) the signaling
Externí odkaz:
https://doaj.org/article/48203a23556e4d6cb4be8929f941ddab
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73151 (2013)
Diet is one of the major lifestyle factors affecting incidence of colorectal cancer (CC), and despite accumulating evidence that numerous diet-derived compounds modulate CC incidence, definitive dietary recommendations are not available. We propose a
Externí odkaz:
https://doaj.org/article/1e9fe49dfc864d30909d22b7c3ad2b5d
Autor:
Darina L. Lazarova, Michael Bordonaro
Publikováno v:
Journal of Cancer
The signing of the National Cancer Act of 1971 by President Nixon marked the beginning of our war on cancer. More than 45 years later, the war is still going steady, with the enemy being almost as strong as in 1971. Furthermore, the increasing rates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::780a9da7512bd464fa2309c767dc89d1
http://europepmc.org/articles/PMC5743724
http://europepmc.org/articles/PMC5743724
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27308 (2011)
Butyrate, a fermentation product of fiber in the colon, acts as a histone deacetylase inhibitor (HDACi) and induces apoptosis in colon cancer (CC) cells in vitro. We have reported that the apoptotic effects of butyrate are dependent upon the hyperact
Externí odkaz:
https://doaj.org/article/fa6157ead0bf44ccbc7ff12fa63a2499
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 5, p 1214 (2019)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Secondary bile acids (BAs) and short chain fatty acids (SCFAs), two major types of bacterial metabolites in the colon, cause opposing effects on colonic inflammation at chronically high physiological levels. Primary BAs play critical roles in cholest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::330cae2c89ae4eba15829c68c0b3cd98
http://www.mdpi.com/1422-0067/20/5/1214
http://www.mdpi.com/1422-0067/20/5/1214
Autor:
Daniel Russo, Jayde T. Hooven, Carmine Cerra, Linda S. Gutierrez, YoungJin Cho, Frank Anzelmi, Darina L. Lazarova, Michael Bordonaro
Publikováno v:
Cancer Medicine
Obesity is associated with colorectal cancer (CRC). This effect might be attributed to adipokine‐supported signaling. We have established that propolis suppresses survival signaling in CRC cells in vitro; therefore, we ascertained the ability of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6784568c6c861b70e78c6c8a7712044
https://doi.org/10.1002/cam4.787
https://doi.org/10.1002/cam4.787
Autor:
Darina L. Lazarova, Michael Bordonaro
Publikováno v:
Journal of Cellular and Molecular Medicine
Dietary fibre protects against colorectal cancer (CRC) most likely through the activity of its fermentation product, butyrate. Butyrate functions as a histone deacetylase inhibitor (HDACi) that hyperactivates Wnt signalling and induces apoptosis of C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f206fc6a5455b3bdb0114eeb5289ca1
https://doi.org/10.1111/jcmm.12850
https://doi.org/10.1111/jcmm.12850
Autor:
Darina L. Lazarova, Michael Bordonaro
Publikováno v:
Journal of Cancer
Neoplastic progression requires accumulation of several mutations (mutation threshold). We hypothesize that obesity raises the risk of microsatellite stable (MSS) colon cancer (CC) at least in part by decreasing the mutation threshold. Thus, we posit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3735fe8eb1b06e964e87c3d7b500b9c2
https://doi.org/10.7150/jca.12352
https://doi.org/10.7150/jca.12352