The effect of single and repeated doses of rivastigmine on gastric myoelectric activity in experimental pigs.

Autor: Chrysostomi Christina Tsianou, Jaroslav Kvetina, Vera Radochova, Darina Kohoutova, Stanislav Rejchrt, Martin Valis, Jana Zdarova Karasova, Ilja Tacheci, Veronika Knoblochova, Ondrej Soukup, Jan Bures

Publikováno v: PLoS ONE, Vol 18, Iss 6, p e0286386 (2023)

BackgroundRivastigmine is a pseudo-irreversible cholinesterase inhibitor used for therapy of Alzheimer's disease and non-Alzheimer dementia syndromes. In humans, rivastigmine can cause significant gastrointestinal side effects that can limit its clin

Externí odkaz: https://doaj.org/article/18153c20d6b24bac911c694b74ac254a

Development and validation of a risk prediction model to diagnose Barrett's oesophagus (MARK-BE): a case-control machine learning approach

Autor: Avi Rosenfeld, PhD, David G Graham, MBBS, Sarah Jevons, PhD, Jose Ariza, RGN, Daryl Hagan, MSc, Ash Wilson, BSc, Samuel J Lovat, Sarmed S Sami, MBBS, Omer F Ahmad, MBBS, Marco Novelli, ProfMBChB, Manuel Rodriguez Justo, MBBS, Alison Winstanley, MBBS, Eliyahu M Heifetz, PhD, Mordehy Ben-Zecharia, PhD, Uria Noiman, PhD, Rebecca C Fitzgerald, ProfMBChB, Peter Sasieni, ProfPhD, Laurence B Lovat, ProfMBBS, Karen Coker, Wanfeng Zhao, Kathryn Brown, Beverley Haynes, Tara Nuckcheddy Grant, Massimiliano di Pietro, Eleanor Dewhurst, Bincy Alias, Leanne Mills, Caroline Wilson, Elizabeth Bird-Lieberman, Jan Bornschein, Yean Lim, Kareem Shariff, Roberto Cayado Lopez, Myrna Udarbe, Claire Shaw, Glynis Rose, Ian Sargeant, M Al-Izzi, Roisin Schimmel, Elizabeth Green, Morgan Moorghen, Reshma Kanani, Mariann Baulf, Jayne Butcher, Adil Butt, Steve Bown, Gideon Lipman, Rami Sweis, Vinay Sehgal, Matthew Banks, Rehan Haidry, John Louis-Auguste, Darina Kohoutova, Sarah Kerr, Victor Eneh, Nigel Butter, Haroon Miah, Rommel Butawan, Grace Adesina, Sabrina Holohan, Joan Idris, Nick Hayes, Shajahan Wahed, Nelson Kath Houghton, Marc Hopton, Anne Eastick, Debasis Majumdar, Kassem Manuf, Lyndsey Fieldson, Helen Bailey, Jacobo Fernandez-Sordo Ortiz, Mina Patel, Suzanne Henry, Samantha Warburton, Jonathan White, Lisa Gadeke, Beverley Longhurst, Richmond Abeseabe, Peter Basford, Rupam Bhattacharyya, Scott Elliot, Roisin Bevan, Carly Brown, Philippa Laverick, Gayle Clifford, Anita Gibbons, Julie Ingmire, Abdullah Mawas, Jacquelyn Harvey, Sharon Cave

Publikováno v: The Lancet: Digital Health, Vol 2, Iss 1, Pp e37-e48 (2020)

Summary: Background: Screening for Barrett's oesophagus relies on endoscopy, which is invasive and few who undergo the procedure are found to have the condition. We aimed to use machine learning techniques to develop and externally validate a simple

Externí odkaz: https://doaj.org/article/a1c2697d1f57456aa1b1b0078466e610

Dextran Sodium Sulphate-Induced Gastrointestinal Injury Further Aggravates the Impact of Galantamine on the Gastric Myoelectric Activity in Experimental Pigs

Autor: Jan Bures, Ilja Tacheci, Jaroslav Kvetina, Vera Radochova, Darina Kohoutova, Martin Valis, Stanislav Rejchrt, Veronika Knoblochova, Jana Zdarova Karasova

Publikováno v: Pharmaceuticals, Vol 14, Iss 6, p 590 (2021)

Galantamine has been used as a treatment for Alzheimer disease. It has a unique, dual mode of action (inhibitor of acetylcholinesterase and allosteric modulator of nicotinic acetylcholine receptors). Nausea (in about 20%), vomiting (10%) and diarrhoe

Externí odkaz: https://doaj.org/article/18dd72615a184ffbb613d098ea3a205c

Pancreatic Cysts: Diagnostic Role of EUS-Guided Microforceps Biopsy and Confocal Laser Endomicroscopy

Autor: Darina Kohoutova, Sameer Zar, Rudolf Repak, Panagiotis Vlavianos, Jan Bures

Publikováno v: Gastroenterology Research and Practice, Vol 2019 (2019)

Frequent use of high-quality cross-sectional imaging has led to a significant rise in diagnosis of pancreatic cystic lesions (PCLs). Despite the fact that enormous effort has been put into the research of PCLs within the last two decades and multiple

Externí odkaz: https://doaj.org/article/96ab49157468453c8a92a24c81e7f66d

Malignant Melanoma of the Gastrointestinal Tract: Symptoms, Diagnosis, and Current Treatment Options

Autor: Darina Kohoutova, Dominic Worku, Hala Aziz, Julian Teare, Justin Weir, James Larkin

Publikováno v: Cells, Vol 10, Iss 2, p 327 (2021)

Malignant melanoma (MM) has become the fifth most frequent cancer in the UK. It is the most common carcinoma to metastasize to the gastrointestinal (GI) tract. MM particularly has an affinity to spread to the small bowel, which is followed by the inv

Externí odkaz: https://doaj.org/article/9d59a21355064a8d85b31d482c6c49d2