Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Darina, Aoun"'
Autor:
Nadia Meddad-Bel Habich, Jean-Edouard Ombetta, Aazdine Lamouri, Françoise Heymans, Léon Assogba, Azali Ahamada-Himidi, Chang-Zhi Dong, Jean-Jacques Godfroid, Darina Aoun, Jack Huet, Latifa Boukli, Carine Mounier
Publikováno v:
European Journal of Medicinal Chemistry. 40:850-861
Starting from 4-tetradecyloxybenzamidine ( PMS815 ), a non-specific inhibitor of GI and GII PLA 2 s, we report in this work the discovery of the specificity through design, synthesis and structure–activity relationships studies of different kinds o
Autor:
Stéphanie Plocki, Darina Aoun, Azali Ahamada-Himidi, Fernanda Tavarès-Camarinha, Chang-Zhi Dong, France Massicot, Jack Huet, Sylvie Adolphe-Pierre, François Chau, Jean-Jacques Godfroid, Nohad Gresh, Jean Edouard Ombetta, Françoise Heymans
Publikováno v:
European Journal of Organic Chemistry. 2005:2747-2757
3-(4-Tetradecyloxybenzyl)-4H-1,2,4-oxadiazol-5-one (PMS1062 or I) can probably act as a PLA2-II inhibitor on the acute inflammation model, but its highly lipophilic character could prevent it from being biodistributed effectively. In this work, based
Autor:
Nadia Meddad-Belhabich, Darina Aoun, Atimé Djimdé, Catherine Redeuilh, Georges Dive, France Massicot, François Chau, Françoise Heymans, Aazdine Lamouri
Publikováno v:
Bioorganicmedicinal chemistry. 18(10)
The group IIA human non-pancreatic secretory phospholipase A 2 (hnp-sPLA 2 ) is one of the enzymes implied in the inflammatory process. In the course of our work on inhibitors of this enzyme we investigated the influence of rigidity of the piperazine
Autor:
Chang-Zhi Dong, Azali Ahamada-Himidi, Stéphanie Plocki, Darina Aoun, Mohamed Touaibia, Nadia Meddad-Bel Habich, Jack Huet, Catherine Redeuilh, Jean-Edouard Ombetta, Jean-Jacques Godfroid, France Massicot, Françoise Heymans
Publikováno v:
Bioorganicmedicinal chemistry. 13(6)
We have recently reported the discovery of a series of specific inhibitors of human group IIA phospholipase A2 (hGIIA PLA2) to display promising in vitro and in vivo properties. Here we describe the influence of different structural modifications on
Autor:
Léon, Assogba, Azali, Ahamada-Himidi, Nadia Meddad-Bel, Habich, Darina, Aoun, Latifa, Boukli, France, Massicot, Carine M, Mounier, Jack, Huet, Aazdine, Lamouri, Jean-Edouard, Ombetta, Jean-Jacques, Godfroid, Chang-Zhi, Dong, Françoise, Heymans
Publikováno v:
European journal of medicinal chemistry. 40(9)
Starting from 4-tetradecyloxybenzamidine (PMS815), a non-specific inhibitor of GI and GII PLA2s, we report in this work the discovery of the specificity through design, synthesis and structure-activity relationships studies of different kinds of PMS8
Publikováno v:
Organic letters. 4(23)
A new synthesis of attenol A is described. Key features of this work include a crucial silicon tether-aided coupling metathesis step and the use of iodoetherification as an efficient protection method for 1,5-ene-ols. [reaction: see text]
Autor:
Stphanie Plocki, Darina Aoun, Azali Ahamada-Himidi, Fernanda Tavars-Camarinha, Chang-Zhi Dong, France Massicot, Jack Huet, Sylvie Adolphe-Pierre, Franois Chau, Jean-Jacques Godfroid, Nohad Gresh, Jean Edouard Ombetta, Franoise Heymans
Publikováno v:
European Journal of Organic Chemistry; Jul2005, Vol. 2005 Issue 13, p2747-2757, 11p