Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Darin Salloum"'
The conversion of normal cells to cancer cells involves a shift from catabolic to anabolic metabolism involving increased glucose uptake and the diversion of glycolytic intermediates into nucleotides, amino acids, and lipids needed for cell growth. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b0fffcfd4de7002dd76f57017ee44c2
https://doi.org/10.1158/1535-7163.c.6536304
https://doi.org/10.1158/1535-7163.c.6536304
Autor:
Renier J. Brentjens, Michel Sadelain, Hans-Guido Wendel, Mithat Gonen, Yvette Bernal, Daniel Li, Lisa M. DeAngelis, Xi Chen, Behroze Vachha, Hui Liu, Justin R. Cross, Terence Purdon, Brigitte Senechal, Xiuyan Wang, Elizabeth Halton, Elena Mead, Jessica Flynn, Isabelle Riviere, Darin Salloum, Jae H. Park, Bianca D. Santomasso
Table S1: Detailed descriptions of all grade neurotoxicity; Table S2: Correlation between CAR T cell phenotype and neurotoxicity; Table S3: Correlation between CSF cytokines and CSF protein concentrations; Table S4: Definitions of CRS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c8df8879a42603ffc44dc3d22f8b0e
https://doi.org/10.1158/2159-8290.22532539
https://doi.org/10.1158/2159-8290.22532539
PDF - 186K, Figure legend for Supp Fig. 1. Table S1: Composition of fatty acid mixture. Table S2: Cell Cycle Distribution of Cells Treated with Rapamycin and EIPA.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a3d0344d7de869b21f0b57a860e907
https://doi.org/10.1158/1535-7163.22499904.v1
https://doi.org/10.1158/1535-7163.22499904.v1
PDF - 2607K, Ras-driven cancer cells are uniquely dependent on exogenous fatty acids.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375ffba1aab2261666d68115dc2dce26
https://doi.org/10.1158/1535-7163.22499907
https://doi.org/10.1158/1535-7163.22499907
Autor:
Renier J. Brentjens, Michel Sadelain, Hans-Guido Wendel, Mithat Gonen, Yvette Bernal, Daniel Li, Lisa M. DeAngelis, Xi Chen, Behroze Vachha, Hui Liu, Justin R. Cross, Terence Purdon, Brigitte Senechal, Xiuyan Wang, Elizabeth Halton, Elena Mead, Jessica Flynn, Isabelle Riviere, Darin Salloum, Jae H. Park, Bianca D. Santomasso
Figure S1: Detailed time course of neurotoxicity for each patient; Figure S2: Serum cytokines in relation to tocilizumab and corticosteroid administration; Figure S3: Hematopoietic toxicity and coagulopathy in severe neurotoxicity; Figure S4: Angiopo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12631e4215ca5ea039e13bf1341b69c9
https://doi.org/10.1158/2159-8290.22532542.v1
https://doi.org/10.1158/2159-8290.22532542.v1
Autor:
Darin Salloum, PhD, Kavita Tundwal, Divy Kangeyan, PhD, Adam Johnson, Neal van Hoeven, PhD, Brian Granger, Jesus Moreno, Ouwen Liang, Pascal Beauchesne, Terry J. Fry, Aaron Foster
Publikováno v:
Blood. 140:4524-4525
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b45db414f8e0d96262a104d7c5e49a2e
https://doi.org/10.1182/blood-2022-168372
https://doi.org/10.1182/blood-2022-168372
Autor:
Hui Liu, Xi Chen, Yvette Bernal, Terence J. Purdon, Lisa M. DeAngelis, Bianca Santomasso, Darin Salloum, Renier J. Brentjens, Hans-Guido Wendel, Michel Sadelain, Brigitte Senechal, Elizabeth Halton, Mithat Gonen, Justin R. Cross, Isabelle Riviere, Daniel Li, Jae H. Park, Jessica Flynn, Behroze Vachha, Xiuyan Wang, Elena Mead
Publikováno v:
Cancer Discovery. 8:958-971
CD19-specific chimeric antigen receptor (CAR) T-cell therapy is highly effective against relapsed or refractory acute lymphoblastic leukemia (ALL), but is hindered by neurotoxicity. In 53 adult patients with ALL, we found a significant association of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abfc9b90928cc28e14343f8755afbd04
https://doi.org/10.1158/2159-8290.cd-17-1319
https://doi.org/10.1158/2159-8290.cd-17-1319
Autor:
Jason S. Lewis, Thomas Reiner, Darin Salloum, Brandon Carney, Wolfgang A. Weber, Susanne Kossatz, Jun Tang, Christian Brand, Hans-Guido Wendel, Ahmad Sadique
Significance Diffuse large B-cell lymphoma (DLBCL) is the most common adult lymphoma, accounting for 37% of all non-Hodgkin lymphoma cases in the United States. Despite an approximate 50% cure rate, refractory or relapsed cases have a poor prognosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c548dc04dd78b5846828b2ab2946f67c
https://europepmc.org/articles/PMC5594659/
https://europepmc.org/articles/PMC5594659/
Autor:
Elyssa Bernfeld, Elizabeth Gorodetsky, Deepak Menon, Pei Hsuan Chen, Darin Salloum, Maria A. Frias, David A. Foster, Alla Akselrod, Ralph J. DeBerardinis, Jessica Sudderth
mTOR, the mammalian target of rapamycin, integrates growth factor and nutrient signals to promote a transformation from catabolic to anabolic metabolism, cell growth, and cell cycle progression. Phosphatidic acid (PA) interacts with the FK506-binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d165d6d670528d591c2159463be38978
https://europepmc.org/articles/PMC5391759/
https://europepmc.org/articles/PMC5391759/
Publikováno v:
Journal of Biological Chemistry. 289:22583-22588
Phosphatidic acid (PA) is a critical metabolite at the heart of membrane phospholipid biosynthesis. However, PA also serves as a critical lipid second messenger that regulates several proteins implicated in the control of cell cycle progression and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a34500b4cdf25a8b8f80058684f0c41
https://doi.org/10.1074/jbc.r114.566091
https://doi.org/10.1074/jbc.r114.566091