Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Darin J Smith"'
Autor:
George N Cox, Elizabeth A Chlipala, Darin J Smith, Sharon J Carlson, Stacie J Bell, Daniel H Doherty
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91990 (2014)
Previously we showed that granulocyte colony-stimulating factor (G-CSF) in vitro bioactivity is preserved when the protein is joined via a flexible 7 amino acid linker to an immunoglobulin-1 (IgG1)-Fc domain and that the G-CSF/IgG1-Fc fusion protein
Externí odkaz:
https://doaj.org/article/22e8833ab57e4fdb9941cddc793de4eb
Autor:
Jay B, Fell, John P, Fischer, Brian R, Baer, James F, Blake, Karyn, Bouhana, David M, Briere, Karin D, Brown, Laurence E, Burgess, Aaron C, Burns, Michael R, Burkard, Harrah, Chiang, Mark J, Chicarelli, Adam W, Cook, John J, Gaudino, Jill, Hallin, Lauren, Hanson, Dylan P, Hartley, Erik J, Hicken, Gary P, Hingorani, Ronald J, Hinklin, Macedonio J, Mejia, Peter, Olson, Jennifer N, Otten, Susan P, Rhodes, Martha E, Rodriguez, Pavel, Savechenkov, Darin J, Smith, Niranjan, Sudhakar, Francis X, Sullivan, Tony P, Tang, Guy P, Vigers, Lance, Wollenberg, James G, Christensen, Matthew A, Marx
Publikováno v:
Journal of medicinal chemistry. 63(13)
Capping off an era marred by drug development failures and punctuated by waning interest and presumed intractability toward direct targeting of KRAS, new technologies and strategies are aiding in the target's resurgence. As previously reported, the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc99717000ce420f505732f20b4224e4
https://pubmed.ncbi.nlm.nih.gov/32250617
https://pubmed.ncbi.nlm.nih.gov/32250617
Publikováno v:
BioProcess international. 3(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::921711fa19d73e7db742ff60b4c2f374
https://pubmed.ncbi.nlm.nih.gov/29899681
https://pubmed.ncbi.nlm.nih.gov/29899681
Autor:
Elizabeth A. Chlipala, Sharon J. Carlson, Mary S. Rosendahl, Darin J. Smith, George N. Cox, Daniel H. Doherty
Publikováno v:
Endocrinology. 148:1590-1597
Recombinant human Growth Hormone (GH) is used to treat growth hormone deficiency in children and adults, and wasting in AIDS patients. GH has a circulating half-life of only a few hours in humans and must be administered to patients by daily injectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c1d9f464d3a5d5f7940d07c353d894
https://doi.org/10.1210/en.2006-1170
https://doi.org/10.1210/en.2006-1170
Autor:
Elizabeth A. Chlipala, Kurt Christensen, Mary S. Rosendahl, Daniel H. Doherty, Dean P. Edwards, George N. Cox, Dana L. Long, Darin J. Smith, Stephen P. Eisenberg
Publikováno v:
Experimental Hematology. 34:697-704
Objective Erythropoietin (Epo) bioactivity is significantly reduced by modification of lysine residues with amine-reactive reagents, which are the most commonly used reagents for attaching polyethylene glycols (PEGs) to proteins to improve protein ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b274e3397eaaa9f4a3ac06ffaf51fc8e
https://doi.org/10.1016/j.exphem.2006.02.011
https://doi.org/10.1016/j.exphem.2006.02.011
Autor:
George N. Cox, Alison M. Bendele, Elizabeth A. Chlipala, Sharon J. Carlson, Daniel H. Doherty, Darin J. Smith
Publikováno v:
Experimental Hematology. 32:441-449
Objective The aim of this study was to determine whether fusion proteins comprising human granulocyte colony-stimulating factor (G-CSF) joined to human immunoglobulin G1 and G4 (IgG1 and IgG4) Fc and C H domains are biologically active and have impro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389083bb982b2e558f5a84cfed5b0921
https://doi.org/10.1016/j.exphem.2004.01.012
https://doi.org/10.1016/j.exphem.2004.01.012
Autor:
Elizabeth A. Chlipala, George N. Cox, Stacie J. Bell, Sharon J. Carlson, Daniel H. Doherty, Darin J. Smith
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91990 (2014)
PLoS ONE
PLoS ONE
Previously we showed that granulocyte colony-stimulating factor (G-CSF) in vitro bioactivity is preserved when the protein is joined via a flexible 7 amino acid linker to an immunoglobulin-1 (IgG1)-Fc domain and that the G-CSF/IgG1-Fc fusion protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b08e6e1dd847082f2b495767d6c0333
http://europepmc.org/articles/PMC3956888?pdf=render
http://europepmc.org/articles/PMC3956888?pdf=render
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1090:70-80
The gene for ciliary neurotrophic factor (CNTF) was cloned from a human genomic DNA library by screening with a DNA fragment amplified from human genomic DNA using the polymerase chain reaction. A DNA sequence coding for human CNTF was placed under c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f6916b1e02a132da34cd405974620d
https://doi.org/10.1016/0167-4781(91)90038-n
https://doi.org/10.1016/0167-4781(91)90038-n
Autor:
Elizabeth A. Chlipala, Mary S. Rosendahl, Jennifer M. Hughes, George N. Cox, Darin J. Smith, Daniel H. Doherty
Publikováno v:
Bioconjugate chemistry. 16(5)
Granulocyte macrophage colony-stimulating factor (GM-CSF) stimulates proliferation of hematopoietic cells of the macrophage and granulocyte lineages and is used clinically to treat neutropenia and other myeloid disorders. Because of its short circula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e14569c4cfbdbad85006e8c9b015c897
https://pubmed.ncbi.nlm.nih.gov/16173810
https://pubmed.ncbi.nlm.nih.gov/16173810
Autor:
Sharon J. Carlson, Mary S. Rosendahl, Darin J. Smith, Daniel H. Doherty, George N. Cox, Elizabeth A. Chlipala
Publikováno v:
Bioconjugate chemistry. 16(1)
Recombinant interferon alpha-2 (IFN-alpha2) is used clinically to treat a variety of viral diseases and cancers. IFN-alpha2 has a short circulating half-life, which necessitates frequent administration to patients. Previous studies showed that it is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08258aeb688e560af03313f277dc111c
https://pubmed.ncbi.nlm.nih.gov/15656592
https://pubmed.ncbi.nlm.nih.gov/15656592