Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Darienne R Myers"'
Autor:
Stephen R Daley, Kristen M Coakley, Daniel Y Hu, Katrina L Randall, Craig N Jenne, Andre Limnander, Darienne R Myers, Noelle K Polakos, Anselm Enders, Carla Roots, Bhavani Balakishnan, Lisa A Miosge, Geoff Sjollema, Edward M Bertram, Matthew A Field, Yunli Shao, T Daniel Andrews, Belinda Whittle, S Whitney Barnes, John R Walker, Jason G Cyster, Christopher C Goodnow, Jeroen P Roose
Publikováno v:
eLife, Vol 2 (2013)
Missense variants are a major source of human genetic variation. Here we analyze a new mouse missense variant, Rasgrp1Anaef, with an ENU-mutated EF hand in the Rasgrp1 Ras guanine nucleotide exchange factor. Rasgrp1Anaef mice exhibit anti-nuclear aut
Externí odkaz:
https://doaj.org/article/99a34eaaa5914ca98a046571e4a1f72a
Autor:
Darienne R. Myers, Clare L. Abram, David Wildes, Amira Belwafa, Alia M. N. Welsh, Christopher J. Schulze, Tiffany J. Choy, Tram Nguyen, Neil Omaque, Yongmei Hu, Mallika Singh, Rich Hansen, Mark A. Goldsmith, Elsa Quintana, Jacqueline A. M. Smith, Clifford A. Lowell
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Shp1, encoded by the gene Ptpn6, is a protein tyrosine phosphatase that transduces inhibitory signals downstream of immunoreceptors in many immune cell types. Blocking Shp1 activity represents an exciting potential immunotherapeutic strategy for the
Externí odkaz:
https://doaj.org/article/2cbd737225784d23b6606ab275c55b74
Autor:
Kayla R. Kulhanek, Darienne R. Myers, Olga Ksionda, Yvonne Vercoulen, Damia Romero-Moya, Jeroen P. Roose
Publikováno v:
STAR Protocols, Vol 1, Iss 2, Pp 100067- (2020)
Summary: Stimulation of naive T lymphocytes via the T cell receptor (TCR) induces distinct phosphorylation patterns that can be used to explore various signaling pathways within the cell. This protocol can be used to characterize different perturbati
Externí odkaz:
https://doaj.org/article/83de435edb3e41ca8312961fb9749d2a
Autor:
Darienne R. Myers, Tannia Lau, Evan Markegard, Hyung W. Lim, Herbert Kasler, Minghua Zhu, Andrea Barczak, John P. Huizar, Julie Zikherman, David J. Erle, Weiguo Zhang, Eric Verdin, Jeroen P. Roose
Publikováno v:
Cell Reports, Vol 19, Iss 8, Pp 1558-1571 (2017)
CD4+ T cells differentiate into T helper cell subsets in feedforward manners with synergistic signals from the T cell receptor (TCR), cytokines, and lineage-specific transcription factors. Naive CD4+ T cells avoid spontaneous engagement of feedforwar
Externí odkaz:
https://doaj.org/article/476a80922ffc43cb9ed247d17d438d28
Publikováno v:
Cell Reports, Vol 27, Iss 6, Pp 1858-1874.e6 (2019)
Summary: Naive CD4+ T cells are an example of dynamic cell homeostasis: T cells need to avoid autoreactivity while constantly seeing self-peptides, yet they must be primed to react to foreign antigens during infection. The instructive signals that ba
Externí odkaz:
https://doaj.org/article/7605c2d233724c01a46bf2bf4baa72d3
Autor:
Jacqueline A.M. Smith, Robert Nichols, Mark A. Goldsmith, Stephen Kelsey, Mallika Singh, Adrian L. Gill, Elena S. Koltun, Amira Belwafa, Nataliya Tobvis Shifrin, David Wildes, Kasia Mordec, Tiffany J. Choy, Darienne R. Myers, Christopher J. Schulze, Elsa Quintana
Supplementary methods, Supplementary Figures S1-S5 with legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bfc470a9f8b3f70c46e9bba9cdfc73e
https://doi.org/10.1158/0008-5472.22424299.v1
https://doi.org/10.1158/0008-5472.22424299.v1
Autor:
Tiffany J. Choy, Nataliya Tobvis Shifrin, Darienne R. Myers, Mark A. Goldsmith, Elena S. Koltun, Adrian Liam Gill, Stephen M. Kelsey, Christopher J. Schulze, Kasia Mordec, Jacqueline Smith, Elsa Quintana, Amira Belwafa, Mallika Singh, Robert J. Nichols, David Wildes
Publikováno v:
Cancer Research. 80:2889-2902
The protein tyrosine phosphatase SHP2 binds to phosphorylated signaling motifs on regulatory immunoreceptors including PD-1, but its functional role in tumor immunity is unclear. Using preclinical models, we show that RMC-4550, an allosteric inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd96edfe3bb7a1d8b7a1649be8ff254
https://doi.org/10.1158/0008-5472.can-19-3038
https://doi.org/10.1158/0008-5472.can-19-3038
Publikováno v:
Lupus Science and Medicine, Vol 8, Iss Suppl 2 (2021)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09890db6e9327df8fabdfd7ef82cda90
https://doi.org/10.1136/lupus-2021-lupus21century.35
https://doi.org/10.1136/lupus-2021-lupus21century.35
Autor:
Matthijs J. D. Baars, Thera Douma, Yvonne Vercoulen, Michiel Vermeulen, Marijke P. Baltissen, Alexander Marson, Femke van Wijk, Darienne R. Myers, Mojtaba Amini, Sytze de Roock, Saikat Banerjee, Dimitre R. Simeonov, Susan Zwakenberg, Jeroen P. Roose, Kayla Kulhanek
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::765d483a19baab6370719d7069a9bea6
https://doi.org/10.1002/eji.201948451/v2/response1
https://doi.org/10.1002/eji.201948451/v2/response1
Autor:
Darienne R. Myers, Jeroen P. Roose, Yvonne Vercoulen, Olga Ksionda, Damia Romero-Moya, Kayla Kulhanek
Publikováno v:
STAR Protocols
STAR Protocols, Vol 1, Iss 2, Pp 100067-(2020)
STAR protocols, vol 1, iss 2
STAR Protocols, Vol 1, Iss 2, Pp 100067-(2020)
STAR protocols, vol 1, iss 2
Summary Stimulation of naive T lymphocytes via the T cell receptor (TCR) induces distinct phosphorylation patterns that can be used to explore various signaling pathways within the cell. This protocol can be used to characterize different perturbatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::947edb96f508651eb7b865837f2bd00b
http://europepmc.org/articles/PMC7580249
http://europepmc.org/articles/PMC7580249