Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Dariel Ashton-Beaucage"'
Autor:
Dariel Ashton-Beaucage, Caroline Lemieux, Christian M Udell, Malha Sahmi, Samuel Rochette, Marc Therrien
Publikováno v:
PLoS Biology, Vol 14, Iss 8, p e1002539 (2016)
RAS-induced MAPK signaling is a central driver of the cell proliferation apparatus. Disruption of this pathway is widely observed in cancer and other pathologies. Consequently, considerable effort has been devoted to understanding the mechanistic asp
Externí odkaz:
https://doaj.org/article/a7465c8bb83b454a9b21988e6f13f708
Autor:
Etienne Caron, Samik Ghosh, Yukiko Matsuoka, Dariel Ashton‐Beaucage, Marc Therrien, Sébastien Lemieux, Claude Perreault, Philippe P Roux, Hiroaki Kitano
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp 1-14 (2010)
Abstract The mammalian target of rapamycin (mTOR) is a central regulator of cell growth and proliferation. mTOR signaling is frequently dysregulated in oncogenic cells, and thus an attractive target for anticancer therapy. Using CellDesigner, a model
Externí odkaz:
https://doaj.org/article/95affcea89444816b50a1f70f39e5b9f
Autor:
Dariel Ashton-Beaucage, Christian M Udell, Patrick Gendron, Malha Sahmi, Martin Lefrançois, Caroline Baril, Anne-Sophie Guenier, Jean Duchaine, Daniel Lamarre, Sébastien Lemieux, Marc Therrien
Publikováno v:
PLoS Biology, Vol 12, Iss 3, p e1001809 (2014)
The small GTPase RAS is among the most prevalent oncogenes. The evolutionarily conserved RAF-MEK-MAPK module that lies downstream of RAS is one of the main conduits through which RAS transmits proliferative signals in normal and cancer cells. Genetic
Externí odkaz:
https://doaj.org/article/01a103f9c3ac49eb8d3c6471457dc715
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1487
Cells respond to changes in their environment, to developmental cues, and to pathogen aggression through the action of a complex network of proteins. These networks can be decomposed into a multitude of signaling pathways that relay signals from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::395a7792c374cd9f74868534c8d02076
https://pubmed.ncbi.nlm.nih.gov/27924555
https://pubmed.ncbi.nlm.nih.gov/27924555
Autor:
Marc Therrien, Dariel Ashton-Beaucage
Publikováno v:
Methods in Molecular Biology ISBN: 9781493964222
Cells respond to changes in their environment, to developmental cues, and to pathogen aggression through the action of a complex network of proteins. These networks can be decomposed into a multitude of signaling pathways that relay signals from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3a2c9b6537abd012026f49952e75ab0
https://doi.org/10.1007/978-1-4939-6424-6_1
https://doi.org/10.1007/978-1-4939-6424-6_1
Autor:
Brian T. Wilhelm, Marieke Rozendaal, Sylvie Mader, Vincent-Philippe Lavallée, Dariel Ashton-Beaucage, Josée Hébert, Sébastien Lemieux, Geneviève Boucher, Douglas J. Hilton, Guy Sauvageau, David Laperrière, Tobias Sargeant, Houssam Ismail
Publikováno v:
Nucleic Acids Research
Genome-wide transcriptome profiling has enabled non-supervised classification of tumours, revealing different sub-groups characterized by specific gene expression features. However, the biological significance of these subtypes remains for the most p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e31adfe207c32b164c79d1252b9dae
https://pubmed.ncbi.nlm.nih.gov/28472340
https://pubmed.ncbi.nlm.nih.gov/28472340
Autor:
Marc Therrien, Dariel Ashton-Beaucage
Publikováno v:
Fly. 5:224-233
Alternative splicing provides one of the major mechanisms by which eukaryotic genomes can increase the diversity of transcripts and protein products encoded by a limited amount of genes. The spliceosome is involved in recognizing and removing introni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52dad505c3d9412cfa9bf95b4c9f01fc
https://doi.org/10.4161/fly.5.3.15569
https://doi.org/10.4161/fly.5.3.15569
Autor:
Dariel Ashton-Beaucage, Marc Therrien
Publikováno v:
médecine/sciences. 26:1067-1073
Les cellules possedent des reseaux proteiques permettant de percevoir des stimulus externes et de reagir a ceux-ci. Ces reseaux sont decomposables en voies de signalisation qui transmettent les signaux du microenvironnement a divers effecteurs cellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::205c982541879474bf9d32b850cb2a72
https://doi.org/10.1051/medsci/201026121067
https://doi.org/10.1051/medsci/201026121067
The PP2C Alphabet Is a Negative Regulator of Stress-Activated Protein Kinase Signaling in Drosophila
Publikováno v:
Genetics. 181:567-579
The Jun N-terminal kinase and p38 pathways, also known as stress-activated protein kinase (SAPK) pathways, are signaling conduits reiteratively used throughout the development and adult life of metazoans where they play central roles in the control o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15ef033ad4baa2139646831cb35431e
https://doi.org/10.1534/genetics.108.096461
https://doi.org/10.1534/genetics.108.096461
Autor:
Samuel Rochette, Christian M. Udell, Dariel Ashton-Beaucage, Caroline Lemieux, Marc Therrien, Malha Sahmi
Publikováno v:
PLoS Biology
PLoS Biology, Vol 14, Iss 8, p e1002539 (2016)
PLoS Biology, Vol 14, Iss 8, p e1002539 (2016)
RAS-induced MAPK signaling is a central driver of the cell proliferation apparatus. Disruption of this pathway is widely observed in cancer and other pathologies. Consequently, considerable effort has been devoted to understanding the mechanistic asp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::908a5a30748bf9c3fe0321136356bef1
https://pubmed.ncbi.nlm.nih.gov/27552662
https://pubmed.ncbi.nlm.nih.gov/27552662